Results 151 to 160 of about 144,727 (384)
Advanced Science, EarlyView.Lynch et al., identified novel targets on the wake‐promoting pathways that can effectively treat pain‐induced sleep disturbances. The authors demonstrated that Calcitonin gene‐related peptide‐expressing neurons (CGRP) in the external lateral parabrachial nucleus (PBelCGRP) serve as the primary relay node for pain stimuli that cause sleep disruption ...
Nicole Lynch +13 more
wiley +1 more source
, 2011 Some exact formulae of the expectation values and probability densities in a weak measurement for an operator ${\bf A}$ which satisfies the property ${\bf A}^{2}=1$ are derived. These formulae include all-order effects of the unitary evolution due to the
Atsushi Nishizawa +4 more
core +1 more source
A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
Nature Biotechnology, 2017 Efforts to develop gene therapies for hearing loss have been hampered by the lack of safe, efficient, and clinically relevant delivery modalities. Here we demonstrate the safety and efficiency of Anc80L65, a rationally designed synthetic vector, for ...
L. D. Landegger +10 more
semanticscholar +1 more source
Advanced Science, EarlyView.Histone lysine crotonylation (Kcr) is a highly conserved posttranslational modification implicated with crucial biological processes. This study reveals that ACSS2‐mediated H4K12cr upregulated CLDN7 transcription to strengthen intestinal epithelial barrier.
Ming Yuan +14 more
wiley +1 more source
ApoE gene therapy: an overview and update [PDF]
, 2005 Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core
Adeno-Associated Virus(AAV)-Mediated Expression of Ornithine Transcarbamylase (OTC) in OTC Deficient spf-ash mMice [PDF]
, 1999 Xuehai Ye +6 more
openalex +1 more source
Advanced Science, EarlyView.USP13 deficiency in intestinal epithelial cells aggravates DSS‐induced colitis by enhancing ER stress and apoptosis. USP13 interacts with GRP78 and reduces its K63‐linked ubiquitination to alleviate epithelial injury. Restoring USP13 expression or targeting the USP13‐GRP78 axis may represent a promising strategy for treating inflammatory bowel disease ...
Chenchen Qian +9 more
wiley +1 more source
Cross-Packaging and Capsid Mosaic Formation in Multiplexed AAV Libraries
Molecular Therapy: Methods & Clinical Development, 2020 Generation and screening of libraries of adeno-associated virus (AAV) variants have emerged as a powerful method for identifying novel capsids for gene therapy applications.
Pauline F. Schmit +13 more
doaj
DNMT3a in the hippocampal CA1 is crucial in the acquisition of morphine self‐administration in rats [PDF]
, 2019 Drug‐reinforced excessive operant responding is one fundamental feature of long-lasting addiction‐like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug‐specific (not natural rewards)
Duan, Ying +8 more
core +1 more source