Results 231 to 240 of about 131,610 (332)

Genetically Encoded SpyTag Enables Modular AAV Retargeting via SpyCatcher-Fused Ligands for Targeted Gene Delivery. [PDF]

ACS Synth Biol
Armbruster A, Hörner M, Wagner HJ, Fink-Straube C, Weber W.   +4 more
europepmc   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Impact of ANCA specificity on risk of cardiovascular events and death in ANCA-associated vasculitis. [PDF]

RMD Open
Idoate Lacasia J, Mourguet M, Villeneuve T, Cassard A, Alric L, De Almeida Chaves S, Moulis G, Piel-Julian M, Sailler L, Chauveau D, Faguer S, Huart A, Ribes D, Guilleminault L, Prévot G, Bost C, Constantin A, Couture G, Gaches F, Michaud M, Mouchon E, Lairez O, Pugnet G.   +22 more
europepmc   +1 more source

223. The Biochemical and Functional Effects of Spontaneous Deamidation of the AAV Capsid on Gene Therapy Vectors [PDF]

, 2014

openalex   +1 more source

Adeno-Associated Virus (AAV) Vector and AAV Empty Particles

Nihon Ika Daigaku Igakkai Zasshi, 2017
Taro Tomono, Kumi Adachi, Takashi Okada
openaire   +2 more sources

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

New inflammatory markers associated with disease activity in patients with antineutrophil cytoplasmic Antibody-associated vasculitis. [PDF]

Clin Exp Med
Cao B, Zhang N, Zhu Y, Hao W, Dong F, Liu R, Wang Y, Li W.   +7 more
europepmc   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

Advanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin, Emma Perrot, Thibault Dhellemmes, Laura Boi, Daniel De Castro Medeiros, Christelle Glangetas, Sylvie Dumas, Sandra Dovero, Nathalie Biendon, Elodie Ladeveze, Maëlle Hardel, Marc Landry, Erwan Bezard, Jérôme Baufreton, Gilberto Fisone, François Georges   +15 more
wiley   +1 more source

Mapping a path forward: addressing disease burden, pathways and solutions in ANCA-associated vasculitis. [PDF]

Rheumatology (Oxford)
Hellmich B.
europepmc   +1 more source

AAVrh10 gene therapy ameliorates central and peripheral nervous system disease in canine globoid cell leukodystrophy (Krabbe disease) [PDF]

, 2018
et al,, Jiang, Xuntain, Ory, Daniel S
core   +1 more source