Results 51 to 60 of about 131,610 (332)

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Retinal gene therapy with a large MYO7A cDNA using adeno-associated virus. [PDF]

, 2013
Usher 1 patients are born profoundly deaf and then develop retinal degeneration. Thus they are readily identified before the onset of retinal degeneration, making gene therapy a viable strategy to prevent their blindness.
Boye, S, Boye, SE, Chiodo, V, Dyka, F, Fofo, H, Hauswirth, WW, Lopes, VS, Louie, CM, Williams, DS   +8 more
core   +1 more source

Packaging of Human Chromosome 19-Specific Adeno-Associated Virus (AAV) Integration Sites in AAV Virions during AAV Wild-Type and Recombinant AAV Vector Production [PDF]

Journal of Virology, 2003
ABSTRACT Adeno-associated virus type 2 (AAV-2) establishes latency by site-specific integration into a unique locus on human chromosome 19, called AAVS1. During the development of a sensitive real-time PCR assay for site-specific integration, AAV-AAVS1 junctions were reproducibly detected in highly purified AAV wild-type and recombinant AAV ...
Daniela, Hüser, Stefan, Weger, Regine, Heilbronn   +2 more
openaire   +2 more sources

The Promise of Solid Lubricants for a Sustainable Future

Advanced Materials, EarlyView.
Lubricants are vital for technology, saving energy and resources. The industry seeks sustainable solutions beyond fossil fuels. Solid lubricants offer extremely low friction and reduce environmental impact, especially in harsh conditions. Can these solids truly replace liquid lubricants, or are they limited to extreme applications?
Philipp G. Grützmacher, Andrey A. Voevodin, András Korényi‐Both, Maria Clelia Righi, Christopher DellaCorte, Nazlim Bagcivan, Ali Erdemir, Carsten Gachot   +7 more
wiley   +1 more source

Laser‐Synthesized Amorphous PdSe2‐x Nanoparticles: A Defect‐Rich Platform for High‐Efficiency SERS, Photocatalysis, and Photothermal Conversion

Advanced Materials Interfaces, EarlyView.
Using femtosecond ablation, we show that an ordered, stoichiometric crystalline PdSe2 target can be controllably converted into a stable, disordered, non‐stoichiometric, and highly functional amorphous nanomaterial, PdSe2−x${\rm PdSe}_{2-x}$. The obtained nanoparticles offer significant advantages over conventional planar plasmon‐free substrates due to
Andrei Ushkov, Nadezhda Belozerova, Dmitriy Dyubo, Ilya Martynov, Alexander Syuy, Daniil Tselikov, Georgy Ermolaev, Sergey V. Bazhenov, Roman I. Romanov, Ivan Kruglov, Anton A. Popov, Alexander Chernov, Alexey D. Bolshakov, Sergey Novikov, Andrey A. Vyshnevyy, Aleksey Arsenin, Andrei V. Kabashin, Gleb I. Tselikov, Valentyn Volkov   +18 more
wiley   +1 more source

Adeno-associated virus vector-based gene therapy for hereditary diseases: current problems of application and approaches to solve them

Биопрепараты: Профилактика, диагностика, лечение
INTRODICTION. Currently, gene therapy based on adeno-associated virus (AAV) vectors faces a  number of barriers, both biomedical and technological, which require studying and overcoming for further development of this gene therapy technology.AIM.
T. V. Egorova, A. A. Piskunov, D. A. Poteryaev   +2 more
doaj   +1 more source

The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning. [PDF]

, 2017
Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood.
Achiro, Jennifer M, Choi, Jinkuk, Gao, Jie, Kim, Sangmok, Li, Sandy, Marosi, Mate, Martin, Kelsey C, Otis, Klara, Portera-Cailliau, Carlos, Tontonoz, Peter   +9 more
core   +3 more sources

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

Adeno-Associated Virus (AAV) - Based Gene Therapies for Retinal Diseases: Where are We?

The Application of Clinical Genetics, 2023
Divya Ail, Hugo Malki, Emilia A Zin, Deniz Dalkara Sorbonne Université, INSERM, CNRS, Department of Therapeutics, Institut de la Vision, Paris, 75012, FranceCorrespondence: Divya Ail, Department of Therapeutics, Institut de la Vision, 17 Rue Moreau ...
Ail D, Malki H, Zin EA, Dalkara D
doaj