Results 81 to 90 of about 507,524 (341)

Dynamics of ABC Transporter P-glycoprotein in Three Conformational States. [PDF]

, 2019
We used hydrogen-deuterium exchange mass spectrometry (HDX-MS) to obtain a comprehensive view of transporter dynamics (85.8% sequence coverage) occurring throughout the multidrug efflux transporter P-glycoprotein (P-gp) in three distinct conformational ...
Chang, Geoffrey, Komives, Elizabeth A, Kopcho, Noah   +2 more
core   +1 more source

Adaptive response of neonatal sepsis-derived Group B Streptococcus to bilirubin [PDF]

, 2018
This work was funded by the Neonatal Unit Endowment Fund, Aberdeen Maternity Hospital. RH is funded by a career researcher fellowship from NHS Research Scotland. SG was funded by the MRC Flagship PhD programme.
Berry, Susan, Collie-Duguid, Elaina S. R., De Paiva Alves, Eduardo, El-Omar, Emad, Gibson, Sophie, Goddard, Mark, Hansen, Richard, Hold, Georgina L., Karcher, Anne Marie, MacLaren, Andrew, Munro, Mike   +10 more
core   +4 more sources

Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii

Nature Communications, 2017
The MacA–MacB–TolC tripartite complex is a transmembrane machine that spans both plasma membrane and outer membrane and actively extrudes substrates, including macrolide antibiotics, virulence factors, peptides and cell envelope precursors.
U. Okada, E. Yamashita, A. Neuberger, M. Morimoto, H. V. van Veen, S. Murakami   +5 more
semanticscholar   +1 more source

Covalent Organic Frameworks for Photocatalytic CO2 Reduction: Metal Integration Principles, Strategies and Functions

Advanced Functional Materials, EarlyView.
Covalent organic frameworks (COFs) with metals have been recognized as versatile platforms for photocatalytic CO2 reduction (CO2PRR). Herein, an overview of metal integration strategies for COFs is systematically summarized. Regulatory mechanisms and structure–activity relationships between metal integration and COF‐based CO2PRR are emphasized.
Jie He, Minxian Zhang, Jinqiang Zhang, Hongqi Sun, Shaobin Wang, Xiaoguang Duan   +5 more
wiley   +1 more source

Search for genes gained by horizontal gene transfer in an entomopoxvirus, with special reference to the analysis of the transfer of an ABC transporter gene

Virus Research
Although it is generally believed that large DNA viruses capture genes by horizontal gene transfer (HGT), the detailed manner of such transfer has not been fully elucidated.
Takafumi N Sugimoto, Akiya Jouraku, Wataru Mitsuhashi   +2 more
doaj   +1 more source

Genome-Wide Identification, Characterization and Phylogenetic Analysis of ATP-Binding Cassette (ABC) Transporter Genes in Common Carp (Cyprinus carpio). [PDF]

PLoS ONE, 2016
The ATP-binding cassette (ABC) gene family is considered to be one of the largest gene families in all forms of prokaryotic and eukaryotic life. Although the ABC transporter genes have been annotated in some species, detailed information about the ABC ...
Xiang Liu, Shangqi Li, Wenzhu Peng, Shuaisheng Feng, Jianxin Feng, Shahid Mahboob, Khalid A Al-Ghanim, Peng Xu   +7 more
doaj   +1 more source

Effect of oxidative stress on ABC transporters: contribution to epilepsy pharmacoresistance [PDF]

, 2017
Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression
Grewal, G. K., Kanojia, N., Kukal, S., Kukreti, R., Kukreti, S., Saso, L.   +5 more
core   +2 more sources

ABC Transporter Genes Show Upregulated Expression in Drug-Resistant Clinical Isolates of Candida auris: A Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes

Frontiers in Microbiology, 2019
ATP-binding cassette (ABC) superfamily members have a key role as nutrient importers and exporters in bacteria. However, their role as drug exporters in eukaryotes brought this superfamily member to even greater prominence.
Mohd Wasi, N. K. Khandelwal, A. Moorhouse, Remya Nair, Poonam Vishwakarma, Gustavo Bravo Ruiz, Zoe K. Ross, A. Lorenz, S. Rudramurthy, A. Chakrabarti, A. Lynn, A. Mondal, N. Gow, R. Prasad   +13 more
semanticscholar   +1 more source

Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges

Advanced Functional Materials, EarlyView.
Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley   +1 more source

Simultaneous prediction of four ATP-binding cassette transporters' substrates using multi-label QSAR [PDF]

, 2016
Efflux by the ATP-binding cassette (ABC) transporters affects the pharmacokinetic profile of drugs and it has been implicated in drug-drug interactions as well as its major role in multi-drug resistance in cancer.
Bentz, Bolón-Canedo, Broccatelli, Demel, Desai, Dragos, Eriksson, Ganta, Gibaja, Gupta, Iyer, Krein, Legrand, Lu-Emerson, Luaces, Maaten, Maggiora, Mak, Marquez, Matsson, Mittal, Montanari, Newby, Oberoi, Pinto, Read, Saeys, Sechidis, Sedykh, Shahlaei, Spolaôr, Stumpfe, Sushko, Sushko, Szakács, Tetko, Tetko, Tsaioun, Tsoumakas, Tsoumakas, Vastag, Wassermann, Wind, Zhang   +43 more
core   +1 more source