Results 1 to 10 of about 109,917 (179)

Revisiting ABC Transporters and Their Clinical Significance in Glioblastoma [PDF]

Pharmaceuticals
Background: The multiple drug-resistant phenomenon has long since plagued the effectiveness of various chemotherapies used in the treatment of patients with glioblastoma (GBM), which is still incurable to this day. ATP-binding cassette (ABC) transporters
Brandon Wee Siang Phon, Shalini Sundramurthi Chelliah, Dina El-Rabie Osman, Saatheeyavaane Bhuvanendran, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin   +5 more
doaj   +2 more sources

Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs [PDF]

Frontiers in Pharmacology
ATP-binding cassette (ABC) transporters are transmembrane proteins expressed commonly in metabolic and excretory organs to control xenobiotic or endobiotic disposition and maintain their homeostasis.
Yimei Wang, Mei-Juan Tu, Ai-Ming Yu
doaj   +2 more sources

Thermodynamics of ABC transporters [PDF]

Protein & Cell, 2015
ABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and
Xuejun C. Zhang, Lei Han, Yan Zhao
doaj   +3 more sources

Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System [PDF]

Cells
ATP-binding cassette (ABC) transporters play a crucial role for the efflux of a wide range of substrates across different cellular membranes. In the central nervous system (CNS), ABC transporters have recently gathered significant attention due to their ...
Maria Villa, Jingyun Wu, Stefanie Hansen, Jens Pahnke   +3 more
doaj   +2 more sources

ABC Transporters [PDF]

FEBS Letters, 2006
ABC transporters are proteins that are involved in the uptake of nutrients and excretion of harmful substances in biological cells. Defects in human ABC transporters can result in severe diseases. Too high ABC transporter activity can lead to non-responsiveness of cancercells to chemotherapy, and resistance of bacteria to antibiotics.
Flügge, U.I., van Meer, G.
  +8 more sources

DeepRTCP: Predicting ATP-Binding Cassette Transporters Based on 1-Dimensional Convolutional Network

Frontiers in Cell and Developmental Biology, 2021
ATP-binding cassette (ABC) transporters can promote cells to absorb nutrients and excrete harmful substances. It plays a vital role in the transmembrane transport of macromolecules.
Zhaoxi Zhang, Juan Wang, Juan Wang, Jiameng Liu   +3 more
doaj   +1 more source

Identification and Validation of Prognostic Related Hallmark ATP-Binding Cassette Transporters Associated With Immune Cell Infiltration Patterns in Thyroid Carcinoma

Frontiers in Oncology, 2022
ATP-binding cassette (ABC) transporters are a large superfamily of membrane proteins that facilitate the translocation of heterogeneous substrates. Studies indicate that ABC transporters may play important roles in various carcinomas.
Lidong Wang, Xiaodan Sun, Xiaodan Sun, Jingni He, Zhen Liu   +4 more
doaj   +1 more source

Effects of deletion of the Streptococcus pneumoniae lipoprotein diacylglyceryl transferase gene lgt on ABC transporter function and on growth in vivo [PDF]

, 2012
Lipoproteins are an important class of surface associated proteins that have diverse roles and frequently are involved in the virulence of bacterial pathogens.
A Bidossi, A Cockayne, A Dintilhac, A Hamilton, A Hiron, A Kadioglu, A Marra, A Polissi, A Yoshimura, AJ Link, AJ Standish, Alain Charbit, AM van Rossum, AW Segal, BA Bray, C Bordier, C Hyams, C Marion, CJ Orihuela, Claire Durmort, CM Petit, D Burnette-Curley, D Ware, DC Desrosiers, DL Hava, E Loisel, E Loisel, EM Eriksson, Emilie Camberlein, FE Jacobsen, GW Lau, H Echchannaoui, H Stoll, H Tettelin, H Tjalsma, H Yamagata, HD Brightbill, HJ Tseng, HM Marriott, IC Sutcliffe, IM Jonsson, J Bubeck Wardenburg, J McCluskey, J Sambrook, Jeremy S. Brown, JM Cohen, Jonathan M. Cohen, JS Brown, JS Brown, JS Brown, JS Brown, K Gan, K Overweg, K Sankaran, KR Gee, L Bayle, L Richards, LJ McAllister, LS Havarstein, M Baumgartner, M Jomaa, M Schmaler, M Tokunaga, N Banaiee, Nathanael MacDonald, P Henneke, P Petrarca, Peter W. M. Hermans, PJ Wichgers Schreur, PW Hermans, R Gabbianelli, R Janulczyk, R Malley, RJ Pezza, S Basavanna, S Bergmann, S Chimalapati, S Das, S Dawid, S Inouye, S Khandavilli, S Knapp, S Leskela, S Machata, SA Lacks, Suneeta Chimalapati, T Arimoto, TE Molzen, Thierry Vernet, Timothy Mitchell, U Koedel, U Samen   +91 more
core   +19 more sources

Clinical Significance of Lipid Transport Function of ABC Transporters in the Innate Immune System

Membranes, 2022
ABC transporters are a large family of proteins that transport a variety of substrates across cell plasma membranes. Because of this, they are involved in many physiological processes.
Stanislav Kotlyarov, Anna Kotlyarova
doaj   +1 more source

Peroxisomal ABC transporters [PDF]

FEBS Letters, 2006
Peroxisomes perform a range of different functions, dependent upon organism, tissue type, developmental stage or environmental conditions, many of which are connected with lipid metabolism. This review summarises recent research on ATP binding cassette (ABC) transporters of the peroxisomal membrane (ABC subfamily D) and their roles in plants, fungi and
Theodoulou, F. L., Holdsworth, M., Baker, A.   +2 more
openaire   +2 more sources