Results 241 to 250 of about 111,036 (294)

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters. [PDF]

J Adv Res
Wu Y, Zhang J, Tian Y, Chi Shing Cho W, Xu HX, Lin ZX, Xian YF.   +6 more
europepmc   +1 more source

Patterns of help‐seeking for mental health problems in 1001 self‐identified neurodivergent adolescents who self‐harm

JCPP Advances, EarlyView.
Adolescents who self‐harm are also more likely to seek support from informal than formal sources and least likely to seek support online. But neurodivergent adolescents who self‐harm are more likely to seek any and especially formal (pastoral school staff or mental health services) support than their peers.
Simona Skripkauskaite, Galit Geulayov, the OxWell Study Team, Mina Fazel, Rohan Borschmann   +4 more
wiley   +1 more source

Deciphering the functional role of clinical mutations in ABCB1, ABCC1, and ABCG2 ABC transporters in endometrial cancer. [PDF]

Front Pharmacol
Gupta A, Singh MS, Singh B.
europepmc   +1 more source

Editorial: Advancing therapeutic strategies: exploring ABC transporters and chemicals affecting their expression and function for disease treatment. [PDF]

Front Pharmacol
Veit G, Matsuo M, Okiyoneda T.
europepmc   +1 more source

Opposing genetic polymorphisms of two ABC transporters contribute to the variation of nukacin resistance in Streptococcus mutans. [PDF]

Appl Environ Microbiol
Sadaoka N, Le MN-T, Kawada-Matsuo M, Eng S, Zendo T, Nakanishi J, Takeda K, Shiba H, Komatsuzawa H.   +8 more
europepmc   +1 more source

Shared structural mechanisms of alternating access between the secondary peptide transporter SbmA and ABC transporters

Beis K, Ettema T, Inaba-Inoue S, Thangaratnarajah C, Silva LAd, Clarke A, Stepien P, Shah A, Ma Y, Hardman K, David S, El-Mkami H, Heddle J, Nomura N, Ogasawara S, Iwata S, Ghilarov D, Pliotas C, Stockner T, Slotboom D.   +19 more
europepmc   +1 more source

Expression of ABC transporters negatively correlates with ectoine biosynthesis in Halomonas campaniensis under NaCl and ultraviolet mutagenesis treatments revealed by transcriptomic and proteomics combined analysis. [PDF]

BMC Genomics
Qiao L, Shen G, Han R, Wang R, Gao X, Xing J, Lin Y, Zhu D.   +7 more
europepmc   +1 more source

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The ABCs of Sterol Transport

Annual Review of Physiology, 2021
Cholesterol homeostasis and trafficking are critical to the maintenance of the asymmetric plasma membrane of eukaryotic cells. Disruption or dysfunction of cholesterol trafficking leads to numerous human diseases. ATP-binding cassette (ABC) transporters play several critical roles in this process, and mutations in these sterol transporters lead to ...
Ashlee M, Plummer, Alan T, Culbertson, Maofu, Liao   +2 more
openaire   +2 more sources