Results 241 to 250 of about 68,283 (287)
20(S)-Ginsenoside Rh2 overcomes gemcitabine resistance in pancreatic cancer by inhibiting LAMC2-Modulated ABC transporters. [PDF]
J Adv ResWu Y +6 more
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Deciphering the functional role of clinical mutations in ABCB1, ABCC1, and ABCG2 ABC transporters in endometrial cancer. [PDF]
Front PharmacolGupta A, Singh MS, Singh B.
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Leukemia and ABC Transporters [PDF]
, 2015 Acute myeloid leukemia (AML) is a heterogeneous disease caused by aberrant proliferation and/or differentiation of myeloid progenitors. However, only ~65% of AML patients respond to induction chemotherapy and the overall survival rate for AML remains low (~24% for 5-year survival).
Yu, Fukuda +2 more
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Annual Review of Physiology, 2021
Cholesterol homeostasis and trafficking are critical to the maintenance of the asymmetric plasma membrane of eukaryotic cells. Disruption or dysfunction of cholesterol trafficking leads to numerous human diseases. ATP-binding cassette (ABC) transporters play several critical roles in this process, and mutations in these sterol transporters lead to ...
Ashlee M, Plummer +2 more
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Cholesterol homeostasis and trafficking are critical to the maintenance of the asymmetric plasma membrane of eukaryotic cells. Disruption or dysfunction of cholesterol trafficking leads to numerous human diseases. ATP-binding cassette (ABC) transporters play several critical roles in this process, and mutations in these sterol transporters lead to ...
Ashlee M, Plummer +2 more
openaire +2 more sources
ABC transporters in lipid transport
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000Since it was found that the P-glycoproteins encoded by the MDR3 (MDR2) gene in humans and the Mdr2 gene in mice are primarily phosphatidylcholine translocators, there has been increasing interest in the possibility that other ATP binding cassette (ABC) transporters are involved in lipid transport.
P, Borst, N, Zelcer, A, van Helvoort
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An inventory of lysosomal ABC transporters [PDF]
FEBS Letters, 2020 ABC transporters fulfill diverse physiological functions in different cellularlocalizations ranging from the plasma membrane to intracellular membranouscompartments.
Gergely SzakÁCs, Rupert Abele
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Mammalian ABC Transporters in Health and Disease [PDF]
Annual Review of Biochemistry, 2002 The ATP-binding cassette (ABC) transporters are a family of large proteins in membranes and are able to transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis.
Piet Borst
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Possible involvement of plant ABC transporters in cadmium detoxification: a cDNA sub-microarray approach [PDF]
Environment International, 2005 As a nontolerant plant to a large number of toxic compounds, Arabidopsis thaliana is a suitable model to study regulation of genes involved in response to heavy metals.
Lucien Bovet +2 more
exaly +2 more sources
Molecular Microbiology, 1998
Bacterial ATP‐binding cassette (ABC) transporters and their homologues in eukaryotic cells form one of the largest superfamilies known today. They function as primary pumps that couple substrate translocation across the cytoplasmic membrane to ATP hydrolysis.
Ehrmann, Michael +4 more
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Bacterial ATP‐binding cassette (ABC) transporters and their homologues in eukaryotic cells form one of the largest superfamilies known today. They function as primary pumps that couple substrate translocation across the cytoplasmic membrane to ATP hydrolysis.
Ehrmann, Michael +4 more
openaire +3 more sources
ABC transporters of staphylococci
Research in Microbiology, 2001Some members of the genus Staphylococcus are important human pathogens, such as Staphylococcus aureus and Staphylococcus epidermidis. ATP binding cassette (ABC) transporters of pathogenic staphylococci are often responsible for antibiotic resistance and for the uptake of essential solutes and are therefore being considered as targets for novel ...
M, Otto, F, Götz
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