Results 51 to 60 of about 110,036 (294)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Genome wide structural prediction of ABC transporter systems in Bacillus subtilis
Frontiers in MicrobiologyABC transporters are a diverse superfamily of membrane protein complexes that utilize the binding/hydrolysis of ATP to power substrate movement across biological membranes or perform mechanical work.
Ashwin Mahendran, Benjamin J. Orlando
doaj +1 more source
Pharmaceutics, 2018 Liver failure is often associated with hepatic encephalopathy, due to dyshomeostasis of the central nervous system (CNS). Under physiological conditions, the CNS homeostasis is precisely regulated by the blood-brain barrier (BBB).
Yilin Fan, Xiaodong Liu
doaj +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis. [PDF]
PLoS Neglected Tropical Diseases, 2012 The ATP binding cassette (ABC) proteins are a family of membrane transporters and regulatory proteins responsible for diverse and critical cellular process in all organisms.
Christopher Kay +5 more
doaj +1 more source
Advanced Functional Materials, EarlyView.By tuning the pore size of mesoporous N‐doped carbon (MPNC) nanospheres as support material for molybdenum sulfide, the electrochemical activity of the composite material for the hydrogen evolution reaction can be optimized. An ideal MPNC pore size of 60 nm allows a high number of molybdenum sulfide active sites while maintaining efficient proton and ...
Niklas Ortlieb +3 more
wiley +1 more source
Progress in Fishery SciencesThe razor clam (Sinonovacula constricta) is an economically important species and one of China´s four traditional mariculture mollusks. The ABC transporter family is one of the oldest membrane protein families, widespread across prokaryotes and ...
Fan YANG +3 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Covalent organic frameworks (COFs) with metals have been recognized as versatile platforms for photocatalytic CO2 reduction (CO2PRR). Herein, an overview of metal integration strategies for COFs is systematically summarized. Regulatory mechanisms and structure–activity relationships between metal integration and COF‐based CO2PRR are emphasized.
Jie He +5 more
wiley +1 more source
Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance
Nature Communications, 2021 Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes ...
Emily L. Giddings +24 more
doaj +1 more source