Investigating the crosstalk between ABCC4 and ABCC5 in 3T3-L1 adipocyte differentiation [PDF]
Frontiers in Molecular BiosciencesIntroductionThe plasma membrane-bound protein, multi-drug resistance-associated protein 4 (MRP4/ABCC4), has gained attention for its pivotal role in facilitating the efflux of a wide range of endogenous and xenobiotic molecules.
Ankit P. Laddha +3 more
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The xenobiotic transporter ABCC4/MRP4 promotes epithelial mesenchymal transition in pancreatic cancer [PDF]
Frontiers in PharmacologyThe xenobiotic transporter ABCC4/MRP4 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and correlates with a more aggressive phenotype and metastatic propensity.
S. N. Gancedo +23 more
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Structural basis of human ABCC4 recognition of cAMP and ligand recognition flexibility [PDF]
Cell & BioscienceBackground ABCC4 (ATP-binding cassette sub-family C member 4) is a transporter protein that is primarily localized to the plasma membrane, and its efflux activity is associated with the progression of various cancers and the development of drug ...
Xuepeng Wen +6 more
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A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance [PDF]
Cells, 2019 Broad-spectrum drug resistance is a major obstacle in cancer treatment, which is often caused by overexpression of ABC transporters the levels of which vary between individuals due to single-nucleotide polymorphisms (SNPs) in their genes.
Megumi Tsukamoto +3 more
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Protein Kinase A and assembly of an ABCC4 protein network [PDF]
Nature CommunicationsCyclic AMP (cAMP) compartmentalization at the plasma membrane employs export by ABCC4, yet the protein machinery that creates spatially restricted signaling has remained unclear.
Jingwen Zhu +13 more
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Clinical and genetic factors associated with kidney tubular dysfunction in a real-life single centre cohort of HIV-positive patients [PDF]
BMC Infectious Diseases, 2017 Background Tenofovir (TDF) is one of the most widely used antiretroviral drug. Despite the high degree of tolerability a small percentage of patients experienced alteration in tubular function during TDF use. Intracellular TDF disposition is regulated by
S. E. Salvaggio +8 more
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ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver [PDF]
Communications BiologyLow expression level of low-density lipoprotein receptor (LDLR) in hepatocytes leads to hypercholesterolemia and eventually contributes to atherosclerotic cardiovascular disease (ASCVD).
Jiaxin Chen +18 more
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The ABCC4 gene is associated with pyometra in golden retriever dogs [PDF]
Scientific Reports, 2021 Pyometra is one of the most common diseases in female dogs, presenting as purulent inflammation and bacterial infection of the uterus. On average 20% of intact female dogs are affected before 10 years of age, a proportion that varies greatly between ...
Maja Arendt +11 more
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A Role of the ABCC4 Gene Polymorphism in Airway Inflammation of Asthmatics [PDF]
Mediators of Inflammation, 2017 The ATP-binding cassette subfamily C member 4 gene encodes a transmembrane protein involved in the export of proinflammatory molecules, including leukotriene, prostaglandin, and sphingosine-1-phosphate across the plasma membrane.
Sailesh Palikhe +6 more
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Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites. [PDF]
Drug Metab DisposMillions of people globally are exposed to the proven human carcinogen arsenic at unacceptable levels in drinking water. In contrast, arsenic is a poor rodent carcinogen, requiring >100-fold higher doses for tumor induction, which may be explained by toxicokinetic differences between humans and mice.
Whitlock BD +11 more
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