Investigating the crosstalk between ABCC4 and ABCC5 in 3T3-L1 adipocyte differentiation [PDF]
Frontiers in Molecular BiosciencesIntroductionThe plasma membrane-bound protein, multi-drug resistance-associated protein 4 (MRP4/ABCC4), has gained attention for its pivotal role in facilitating the efflux of a wide range of endogenous and xenobiotic molecules.
Ankit P. Laddha +3 more
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The xenobiotic transporter ABCC4/MRP4 promotes epithelial mesenchymal transition in pancreatic cancer [PDF]
Frontiers in PharmacologyThe xenobiotic transporter ABCC4/MRP4 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and correlates with a more aggressive phenotype and metastatic propensity.
S. N. Gancedo +23 more
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Structural basis of human ABCC4 recognition of cAMP and ligand recognition flexibility [PDF]
Cell & BioscienceBackground ABCC4 (ATP-binding cassette sub-family C member 4) is a transporter protein that is primarily localized to the plasma membrane, and its efflux activity is associated with the progression of various cancers and the development of drug ...
Xuepeng Wen +6 more
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Protein Kinase A and assembly of an ABCC4 protein network [PDF]
Nature CommunicationsCyclic AMP (cAMP) compartmentalization at the plasma membrane employs export by ABCC4, yet the protein machinery that creates spatially restricted signaling has remained unclear.
Jingwen Zhu +13 more
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Effects of cAMP and CFTR modulation on apical fluid pH in human airway Calu-3 cells. [PDF]
Physiol RepAbstract The airway epithelium serves as the first line of defense against inhaled insults present in the external environment by acting as a physical barrier and through host defense mechanisms. Proper maintenance of these host defense mechanisms relies on the regulation of airway surface liquid (ASL) composition and properties, a process that is ...
Nguyen JP, Milad N, Hirota JA.
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ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver [PDF]
Communications BiologyLow expression level of low-density lipoprotein receptor (LDLR) in hepatocytes leads to hypercholesterolemia and eventually contributes to atherosclerotic cardiovascular disease (ASCVD).
Jiaxin Chen +18 more
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Identification of Novel Biomarkers Associated with Corticosteroid Resistance in Asthma by Bioinformatics Analysis and Experimental Validation [PDF]
Journal of Inflammation ResearchLingling Xuan,* Lulu Ren,* Wen Zhang, Zhuoling An Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence ...
Xuan L, Ren L, Zhang W, An Z
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Influence of Genetic Variation of GST, CYP, and ABC on the Safety and Efficacy of Cyclophosphamide‐Based Therapy [PDF]
Clinical and Translational ScienceCyclophosphamide (CTX) is one of the most widely used drugs in the clinical treatment of tumors and autoimmune diseases. The correlation between CYP, GST, and ABC gene polymorphisms and CTX activity and its induced toxicity has been extensively studied ...
Zhong‐Wei Yao +9 more
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Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis [PDF]
Frontiers in ImmunologyBackgroundRheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear.
Lijuan Feng +4 more
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Knockdown of an ATP-binding cassette transporter in resistant western corn rootworm larvae partially reverses resistance to eCry3.1Ab protein [PDF]
Scientific ReportsThe western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte, has evolved resistance to nearly every management tactic utilized in the field.
Adriano E. Pereira +8 more
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