Characterization of zebrafish Abcc4 as an efflux transporter of organochlorine pesticides.
PLoS ONE, 2014 DDT and lindane are highly toxic organochlorine pesticides and posing adverse effects on the environment and public health due to their frequent usage in developing countries.
Xing Lu +5 more
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The cytokinin efflux transporter ABCC4 participates in Arabidopsis root system development. [PDF]
Plant PhysiolAbstract The directional and sequential flow of cytokinin in plants is organized by a complex network of transporters. Genes involved in several aspects of cytokinin transport have been characterized; however, much of the elaborate system remains elusive.
Uragami T +7 more
europepmc +3 more sources
Identification of Novel Biomarkers Associated with Corticosteroid Resistance in Asthma by Bioinformatics Analysis and Experimental Validation [PDF]
Journal of Inflammation ResearchLingling Xuan,* Lulu Ren,* Wen Zhang, Zhuoling An Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence ...
Xuan L, Ren L, Zhang W, An Z
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Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis [PDF]
Frontiers in ImmunologyBackgroundRheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear.
Lijuan Feng +4 more
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Transport of eicosapentaenoic acid-derived PGE₃, PGF(3α), and TXB₃ by ABCC4.
PLoS ONE, 2014 BackgroundEicosapentaenoic acid-derived prostaglandin (PG) E3, PGF(3α), and thromboxane (TX) B3 are bioactive lipid mediators which have anti-cancer and anti-inflammatory effects.
Nobuaki Tanaka +2 more
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Knockdown of an ATP-binding cassette transporter in resistant western corn rootworm larvae partially reverses resistance to eCry3.1Ab protein [PDF]
Scientific ReportsThe western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte, has evolved resistance to nearly every management tactic utilized in the field.
Adriano E. Pereira +8 more
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The Role of Candidate Polymorphisms in Drug Transporter Genes on High‐Dose Methotrexate in the Consolidation Phase of the AIEOP‐BFM ALL 2009 Protocol [PDF]
Clinical and Translational ScienceHigh‐dose methotrexate (HD‐MTX) infusions are commonly used to consolidate remission in children with acute lymphoblastic leukemia (ALL). We investigate the potential role of candidate polymorphisms in SLCO1B1 (rs4149056 and rs2306283), ABCB1 (rs1045642),
Stefania Braidotti +15 more
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ABCC4 suppresses glioblastoma progression and recurrence by restraining cGMP-PKG signalling. [PDF]
Br J CancerCyclic nucleotides are critical mediators of cellular signalling in glioblastoma. However, the clinical relevance and mechanisms of regulating cyclic nucleotides in glioblastoma progression and recurrence have yet to be thoroughly explored.In silico, mRNA, and protein level analyses identified the primary regulator of cyclic nucleotides in recurrent ...
Chiang JY +9 more
europepmc +3 more sources
Telomere-to-telomere genome assembly of a male goat reveals variants associated with cashmere traits [PDF]
Nature CommunicationsA complete goat (Capra hircus) reference genome enhances analyses of genetic variation, thus providing insights into domestication and selection in goats and related species. Here, we assemble a telomere-to-telomere (T2T) gap-free genome (2.86 Gb) from a
Hui Wu +22 more
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Association of ABCB1, ABCC4 and SLCO1B1 polymorphisms with high dose-MTX blood concentration and adverse events in childhood acute lymphoblastic leukemia [PDF]
Jichu yixue yu linchuang, 2022 Objective To investigate potential relationship between gene polymorphisms of ATP-binding cassette B1, C4 (ABCB1, ABCC4) and solute carrier organic anion transporter 1B1 gene(SLCO1B1) with methotrexate (MTX) blood drug concentration and high dose-MTX (HD-
TIAN Xiao-yi, LIU Ying, YAO Yao, GU Xiu-li, LI Ai-hua, ZHENG Hu-yong, SONG Wen-qi
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