A Human ABC Transporter ABCC4 Gene SNP (rs11568658, 559 G > T, G187W) Reduces ABCC4-Dependent Drug Resistance [PDF]
Cells, 2019 Broad-spectrum drug resistance is a major obstacle in cancer treatment, which is often caused by overexpression of ABC transporters the levels of which vary between individuals due to single-nucleotide polymorphisms (SNPs) in their genes.
Megumi Tsukamoto +3 more
doaj +4 more sources
Characterization of zebrafish Abcc4 as an efflux transporter of organochlorine pesticides.
PLoS ONE, 2014 DDT and lindane are highly toxic organochlorine pesticides and posing adverse effects on the environment and public health due to their frequent usage in developing countries.
Xing Lu +5 more
doaj +4 more sources
Transport of eicosapentaenoic acid-derived PGE₃, PGF(3α), and TXB₃ by ABCC4.
PLoS ONE, 2014 BackgroundEicosapentaenoic acid-derived prostaglandin (PG) E3, PGF(3α), and thromboxane (TX) B3 are bioactive lipid mediators which have anti-cancer and anti-inflammatory effects.
Nobuaki Tanaka +2 more
doaj +3 more sources
A Role of the ABCC4 Gene Polymorphism in Airway Inflammation of Asthmatics [PDF]
Mediators of Inflammation, 2017 The ATP-binding cassette subfamily C member 4 gene encodes a transmembrane protein involved in the export of proinflammatory molecules, including leukotriene, prostaglandin, and sphingosine-1-phosphate across the plasma membrane.
Sailesh Palikhe +6 more
doaj +4 more sources
The ABCC4 gene is associated with pyometra in golden retriever dogs [PDF]
Scientific Reports, 2021 Pyometra is one of the most common diseases in female dogs, presenting as purulent inflammation and bacterial infection of the uterus. On average 20% of intact female dogs are affected before 10 years of age, a proportion that varies greatly between ...
Maja Arendt +11 more
doaj +7 more sources
The Role of Candidate Polymorphisms in Drug Transporter Genes on High‐Dose Methotrexate in the Consolidation Phase of the AIEOP‐BFM ALL 2009 Protocol [PDF]
Clinical and Translational ScienceHigh‐dose methotrexate (HD‐MTX) infusions are commonly used to consolidate remission in children with acute lymphoblastic leukemia (ALL). We investigate the potential role of candidate polymorphisms in SLCO1B1 (rs4149056 and rs2306283), ABCB1 (rs1045642),
Stefania Braidotti +15 more
doaj +2 more sources
Association of ABCB1, ABCC4 and SLCO1B1 polymorphisms with high dose-MTX blood concentration and adverse events in childhood acute lymphoblastic leukemia [PDF]
Jichu yixue yu linchuang, 2022 Objective To investigate potential relationship between gene polymorphisms of ATP-binding cassette B1, C4 (ABCB1, ABCC4) and solute carrier organic anion transporter 1B1 gene(SLCO1B1) with methotrexate (MTX) blood drug concentration and high dose-MTX (HD-
TIAN Xiao-yi, LIU Ying, YAO Yao, GU Xiu-li, LI Ai-hua, ZHENG Hu-yong, SONG Wen-qi
doaj +1 more source
Implications of ABCC4–Mediated cAMP Efflux for CRC Migration [PDF]
Cancers, 2020 Colorectal cancer (CRC) presents significant molecular heterogeneity. The cellular plasticity of epithelial to mesenchymal transition (EMT) is one of the key factors responsible for the heterogeneous nature of metastatic CRC. EMT is an important regulator of ATP binding cassette (ABC) protein expression; these proteins are the active transporters of a ...
Jakub Kryczka +3 more
openaire +2 more sources
The ABCC4 membrane transporter modulates platelet aggregation [PDF]
Blood, 2015 Key Points The ABC transporter, ABCC4, localizes to the platelet plasma membrane and regulates aggregation by exporting cAMP and antithrombotic drugs.
Satish B. Cheepala +10 more
openaire +2 more sources
Frontiers in Genetics, 2022 The purpose of this investigation was to assess the diagnostic and prognostic significance of ATP binding cassette subfamily C (ABCC) genes in hepatocellular carcinoma (HCC).
Xin Zhou +19 more
doaj +1 more source