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Influence of Genetic Variation of GST, CYP, and ABC on the Safety and Efficacy of Cyclophosphamide-Based Therapy. [PDF]
Clin Transl SciABSTRACT Cyclophosphamide (CTX) is one of the most widely used drugs in the clinical treatment of tumors and autoimmune diseases. The correlation between CYP, GST, and ABC gene polymorphisms and CTX activity and its induced toxicity has been extensively studied, but with inconsistent conclusions.
Yao ZW +9 more
europepmc +2 more sources
Implications of ABCC4–Mediated cAMP Efflux for CRC Migration [PDF]
Cancers, 2020 Colorectal cancer (CRC) presents significant molecular heterogeneity. The cellular plasticity of epithelial to mesenchymal transition (EMT) is one of the key factors responsible for the heterogeneous nature of metastatic CRC. EMT is an important regulator of ATP binding cassette (ABC) protein expression; these proteins are the active transporters of a ...
Jakub Kryczka +3 more
openaire +2 more sources
The ABCC4 membrane transporter modulates platelet aggregation [PDF]
Blood, 2015 Key Points The ABC transporter, ABCC4, localizes to the platelet plasma membrane and regulates aggregation by exporting cAMP and antithrombotic drugs.
Satish B. Cheepala +10 more
openaire +2 more sources
Go with the flow: ABCC4 mediates cytokinin efflux to control root development. [PDF]
Plant PhysiolTorres-Martínez HH.
europepmc +3 more sources
Frontiers in Genetics, 2022 The purpose of this investigation was to assess the diagnostic and prognostic significance of ATP binding cassette subfamily C (ABCC) genes in hepatocellular carcinoma (HCC).
Xin Zhou +19 more
doaj +1 more source
Functional Expression of Multidrug Resistance Protein 4 MRP4/ABCC4 [PDF]
SLAS Discovery, 2019 To study the function and structure of membrane proteins, high quantities of pure and stable protein are needed. One of the first hurdles in accomplishing this is expression of the membrane protein at high levels and in a functional state. Membrane proteins are naturally expressed at low levels, so finding a suitable host for overexpression is ...
David Hardy +3 more
openaire +3 more sources
ABCC4 is regulated by microRNA-124a and microRNA-506 [PDF]
Biochemical Pharmacology, 2014 Multidrug resistance protein 4 (MRP4, ABCC4) is an efflux membrane transporter expressed in renal tubules, hepatocytes, brain capillaries, prostate and blood cells. MRP4 drives energy dependent efflux of important physiological and pharmacological compounds.
Markova, Svetlana M, Kroetz, Deanna L
openaire +4 more sources
The role of drug transporters in the kidney: lessons from tenofovir [PDF]
, 2014 Tenofovir disoproxil fumarate, the prodrug of nucleotide reverse transcriptase inhibitor tenofovir, shows high efficacy and relatively low toxicity in HIV patients.
Moss, DM, Neary, M, Owen, A
core +6 more sources
ABCC4 Is a Determinant of Cytarabine‐Induced Cytotoxicity and Myelosuppression [PDF]
Clinical and Translational Science, 2016 Resistance to cytarabine remains a major challenge in the treatment of acute myeloid leukemia (AML). Based on previous studies implicating ABCC4/MRP4 in the transport of nucleosides, we hypothesized that cytarabine is sensitive to ABCC4‐mediated efflux, thereby decreasing its cytotoxic response against AML blasts.
Drenberg, CD +8 more
openaire +2 more sources
Frontiers in Oncology, 2020 Docetaxel is a major treatment for advanced prostate cancer (PCa); however, its resistance compromises clinical effectiveness. Estrogen receptor-related receptor alpha (ERRα) belongs to an orphan nuclear receptor superfamily and was recently found to be ...
Houbao Huang +24 more
doaj +1 more source