Results 21 to 30 of about 3,461 (145)

Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites. [PDF]

Drug Metab Dispos
Millions of people globally are exposed to the proven human carcinogen arsenic at unacceptable levels in drinking water. In contrast, arsenic is a poor rodent carcinogen, requiring >100-fold higher doses for tumor induction, which may be explained by toxicokinetic differences between humans and mice.
Whitlock BD, Ma Y, Conseil G, O'Brien AR, Banerjee M, Swanlund DP, Lin ZP, Wang Y, Le XC, Schuetz JD, Cole SPC, Leslie EM.   +11 more
europepmc   +3 more sources

Functional Expression of Multidrug Resistance Protein 4 MRP4/ABCC4 [PDF]

SLAS Discovery, 2019
To study the function and structure of membrane proteins, high quantities of pure and stable protein are needed. One of the first hurdles in accomplishing this is expression of the membrane protein at high levels and in a functional state. Membrane proteins are naturally expressed at low levels, so finding a suitable host for overexpression is ...
David Hardy, Roslyn M. Bill, Anass Jawhari, Alice J. Rothnie   +3 more
openaire   +3 more sources

ABCC4 is regulated by microRNA-124a and microRNA-506 [PDF]

Biochemical Pharmacology, 2014
Multidrug resistance protein 4 (MRP4, ABCC4) is an efflux membrane transporter expressed in renal tubules, hepatocytes, brain capillaries, prostate and blood cells. MRP4 drives energy dependent efflux of important physiological and pharmacological compounds.
Markova, Svetlana M, Kroetz, Deanna L
openaire   +4 more sources

The cytokinin efflux transporter ABCC4 participates in Arabidopsis root system development. [PDF]

Plant Physiol
Abstract The directional and sequential flow of cytokinin in plants is organized by a complex network of transporters. Genes involved in several aspects of cytokinin transport have been characterized; however, much of the elaborate system remains elusive.
Uragami T, Kiba T, Kojima M, Takebayashi Y, Tozawa Y, Hayashi Y, Kinoshita T, Sakakibara H.   +7 more
europepmc   +3 more sources

ABCC4 Is a Determinant of Cytarabine‐Induced Cytotoxicity and Myelosuppression [PDF]

Clinical and Translational Science, 2016
Resistance to cytarabine remains a major challenge in the treatment of acute myeloid leukemia (AML). Based on previous studies implicating ABCC4/MRP4 in the transport of nucleosides, we hypothesized that cytarabine is sensitive to ABCC4‐mediated efflux, thereby decreasing its cytotoxic response against AML blasts.
Drenberg, CD, Hu, S, Li, L, Buelow, DR, Orwick, SJ, Gibson, AA, Schuetz, JD, Sparreboom, A, Baker, SD   +8 more
openaire   +2 more sources

Increased ABCC4 Expression Induced by ERRα Leads to Docetaxel Resistance via Efflux of Docetaxel in Prostate Cancer

Frontiers in Oncology, 2020
Docetaxel is a major treatment for advanced prostate cancer (PCa); however, its resistance compromises clinical effectiveness. Estrogen receptor-related receptor alpha (ERRα) belongs to an orphan nuclear receptor superfamily and was recently found to be ...
Houbao Huang, Jing Li, Jing Shen, Jing Shen, Ling Lin, Ling Lin, Xu Wu, Xu Wu, Shixin Xiang, Shixin Xiang, Yawei Li, Yujie Xu, Qijie Zhao, Qijie Zhao, Yueshui Zhao, Yueshui Zhao, Parham Jabbarzadeh Kaboli, Parham Jabbarzadeh Kaboli, Mingxing Li, Mingxing Li, Xiang Li, Weiping Wang, Qinglian Wen, Zhangang Xiao, Zhangang Xiao   +24 more
doaj   +1 more source

Founder genetic variants of ABCC4 and ABCC11 in the Japanese population are not associated with the development of subacute myelo‐optico‐neuropathy (SMON)

Molecular Genetics & Genomic Medicine, 2022
Background Subacute myelo‐optico‐neuropathy (SMON) is a severe neurological disorder associated with clioquinol administration, which frequently occurred in Japan during the 1950s and 1960s.
Hideki Matsumoto, Hideo Sasai, Norio Kawamoto, Masato Katsuyama, Makoto Minamiyama, Satoshi Kuru, Toshiyuki Fukao, Hidenori Ohnishi, SMON research group members   +8 more
doaj   +1 more source

Potentiation of long-acting β2-agonist and glucocorticoid responses in human airway epithelial cells by modulation of intracellular cAMP

Respiratory Research, 2021
Introduction Over 300 million people in the world live with asthma, resulting in 500,000 annual global deaths with future increases expected. It is estimated that around 50–80% of asthma exacerbations are due to viral infections. Currently, a combination
Yechan Kim, Vincent Hou, Ryan D. Huff, Jennifer A. Aguiar, Spencer Revill, Nicholas Tiessen, Quynh Cao, Matthew S. Miller, Mark D. Inman, Kjetil Ask, Andrew C. Doxey, Jeremy A. Hirota   +11 more
doaj   +1 more source

HOXA13, Negatively Regulated by miR-139-5p, Decreases the Sensitivity of Gastric Cancer to 5-Fluorouracil Possibly by Targeting ABCC4

Frontiers in Oncology, 2021
PurposeChemoresistance remains a major challenge in the therapy of gastric cancer (GC). The homeobox (HOX) gene family has gained attention in carcinogenesis and chemoresistance.
Zhengqian Chen, Zhengqian Chen, Zhiwei Qin, Lei Li, Qi Wo, Xia Chen   +5 more
doaj   +1 more source

Whole genome resequencing reveals an association of ABCC4 variants with preaxial polydactyly in pigs

BMC Genomics, 2020
Background Polydactyly is one of the most common congenital limb dysplasia in many animal species. Although preaxial polydactyly (PPD) has been comprehensively studied in humans as a common abnormality, the genetic variations in other animal species have
Cheng Ma, Saber Khederzadeh, Adeniyi C. Adeola, Xu-Man Han, Hai-Bing Xie, Ya-Ping Zhang   +5 more
doaj   +1 more source