Results 41 to 50 of about 6,676 (188)

Whole genome resequencing reveals an association of ABCC4 variants with preaxial polydactyly in pigs

BMC Genomics, 2020
Background Polydactyly is one of the most common congenital limb dysplasia in many animal species. Although preaxial polydactyly (PPD) has been comprehensively studied in humans as a common abnormality, the genetic variations in other animal species have
Cheng Ma, Saber Khederzadeh, Adeniyi C. Adeola, Xu-Man Han, Hai-Bing Xie, Ya-Ping Zhang   +5 more
doaj   +1 more source

Platelet Transcriptome Profiling in HIV and ATP-Binding Cassette Subfamily C Member 4 (ABCC4) as a Mediator of Platelet Activity

JACC: Basic to Translational Science, 2018
An unbiased platelet transcriptome profile identified ATP binding cassette subfamily C member 4 (ABCC4) as a novel mediator of platelet activity in virologically suppressed human immunodeficiency virus (HIV)-infected subjects on antiretroviral therapy ...
Emanuela Marcantoni, PhD, Nicole Allen, BS, Matthew R. Cambria, BA, Rebecca Dann, BS, Michael Cammer, BS, Tenzin Lhakhang, BS, Meagan P. O’Brien, MD, Benjamin Kim, BS, Tilla Worgall, MD, PhD, Adriana Heguy, PhD, Aristotelis Tsirigos, PhD, Jeffrey S. Berger, MD, MS   +11 more
doaj   +1 more source

Effect of polymorphisms in drug metabolism and transportation on plasma concentration of atorvastatin and its metabolites in patients with chronic kidney disease

Frontiers in Pharmacology, 2023
Dyslipidemia due to renal insufficiency is a common complication in patients with chronic kidney diseases (CKD), and a major risk factor for the development of cardiovascular events.
Zebin Jiang, Zemin Wu, Ruixue Liu, Qin Du, Xian Fu, Min Li, Yongjun Kuang, Shen Lin, Jiaxuan Wu, Weiji Xie, Ganggang Shi, Yanqiang Peng, Fuchun Zheng, Fuchun Zheng   +13 more
doaj   +1 more source

Pharmacokinetics of Tenofovir Alafenamide Fumarate and Tenofovir in the Chinese People: Effects of Non-Genetic Factors and Genetic Variations

Pharmacogenomics and Personalized Medicine, 2021
Xue Li,1,* Xin-Yi Tan,2,* Xue-Jun Cui,3 Ming Yang,1 Chao Chen,1 Xiao-Yun Chen2 1Phase I Clinical Research Laboratory of Shanghai LongHua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China ...
Li X, Tan XY, Cui XJ, Yang M, Chen C, Chen XY   +5 more
doaj  

Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin.

PLoS ONE, 2011
Exposure of J774 mouse macrophages to stepwise increasing concentrations of ciprofloxacin, an antibiotic inhibiting bacterial topoisomerases, selects for resistant cells that overexpress the efflux transporter Abcc4 (Marquez et al.
Béatrice Marquez, Geneviève Ameye, Coralie M Vallet, Paul M Tulkens, Hélène A Poirel, Françoise Van Bambeke   +5 more
doaj   +1 more source

Small extracellular vesicles secreted by vaginal fibroblasts exert inhibitory effect in female stress urinary incontinence through regulating the function of fibroblasts.

PLoS ONE, 2021
Stress urinary incontinence (SUI) is a common condition in women and associated with extra-cellular matrix (ECM) reconstruction, which is mainly regulated by fibroblasts. However, the underlying mechanism remains obscure.
Xiaoyan Sun, Huimin Zhu, Wenjuan Li, Li Zhao, Wenhua Li, Xiaoyong Li, Zhenwei Xie   +6 more
doaj   +1 more source

Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons [PDF]

Human Molecular Genetics, 2003
Drug transporters are an important part of the defense of cells against cytotoxic agents. One major group of transporters is known as multidrug resistance associated proteins (MRP; ABCC gene family). The MRPs belong to the ATP binding cassette transporter superfamily. One family member, ABCC4 (also known as MRP4) functions as a cellular efflux pump for
Jatinder Kaur, Lamba, Masashi, Adachi, Daxi, Sun, Jaana, Tammur, Erin G, Schuetz, Rando, Allikmets, John D, Schuetz   +6 more
openaire   +2 more sources

Prognostic significance and molecular mechanism of ATP-binding cassette subfamily C member 4 in resistance to neoadjuvant radiotherapy of locally advanced rectal carcinoma.

PLoS ONE, 2014
BackgroundMechanism of radioresistance in rectal carcinoma remains largely unknown. We aimed to evaluate the predictive role of ATP-binding cassette subfamily C member 4 (ABCC4) in locally advanced rectal carcinoma and explore possible molecular ...
Zhiqi Yu, Chang Zhang, Rui Chai, Yan Du, Xianhua Gao, Junjie Xing, Enda Yu, Wei Zhang, Xiaoqing Zhang, Guangwen Cao, Chuangang Fu   +10 more
doaj   +1 more source

Polymorphisms in the CYP2A6 and ABCC4 genes are associated with a protective effect on chronic myeloid leukemia in the Brazilian Amazon population

Molecular Genetics & Genomic Medicine, 2021
Background Susceptibility to Chronic Myeloid Leukemia (CML) may be modulated by genetic variables. However, the majority of previous investigations have focused on genetically homogeneous populations, resulting in a lack of evidence on how genetic ...
Natasha Monte, Karla B. C. C. Pantoja, Juliana C. G. Rodrigues, Darlen C. deCarvalho, Tereza C. B. Azevedo, Esdras E. B. Pereira, Paulo P. deAssumpção, Sidney E. B. dosSantos, Marianne R. Fernandes, Ney P. C. dosSantos   +9 more
doaj   +1 more source

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]

, 2017
There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Löscher, Wolfgang, Römermann, Kerstin, Sweet, Douglas H., Töllner, Kathrin   +7 more
core   +2 more sources