Results 61 to 70 of about 3,461 (145)
Molecular Oncology, Volume 19, Issue 12, Page 3729-3749, December 2025.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Lamivudine and tenofovir pharmacokinetic variability in people with HIV in Papua New Guinea
British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3412-3421, December 2025.Aims Demographics and kidney function contribute to variability in lamivudine and tenofovir drug concentrations. The aim was to assess, for the first time, the pharmacokinetic variability of lamivudine and tenofovir in Papua New Guinean (PNG) HIV/AIDS patients.
Natália Bordin Andriguetti +4 more
wiley +1 more source
The Role of DNA Methyltransferases in Urinary System Diseases
Cancer Innovation, Volume 4, Issue 6, December 2025.Multiple signaling pathways mediated by DNMTs in the formation of renal fibrosis: (a) DNMTs suppress the expression of transcription factor KLF4 by mediating promoter hypermethylation, thereby promoting epithelial–mesenchymal transition and contributing to the development of renal fibrosis; (b) oxidative stress can upregulate the levels of DNMTs, which
Wei Dong +11 more
wiley +1 more source
Scientific Reports, 2017 To investigate the association of microRNA (miRNA) binding-site polymorphisms in the drug transporter genes with the efficacy of 5-Fluorouracil (5-FU)/capecitabine-based chemotherapy in colorectal cancer (CRC), 6 polymorphisms were determined in 432 CRC ...
Qi Chen +7 more
doaj +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 12, December 2025.Low‐dose short‐chain PFAS exposures enhance hepatic ABC transporter activity and expression, revealing that environmentally relevant concentrations can reprogram xenobiotic transport pathways and potentially influence drug metabolism, bile acid handling, and lipid homeostasis, highlighting a molecular link between chronic PFAS exposure and altered ...
Gracen E. Collier, Ramon Lavado
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
The FoxM1-ABCC4 axis mediates carboplatin resistance in human retinoblastoma Y-79 cells [PDF]
Acta Biochimica et Biophysica Sinica, 2018 Carboplatin is the most commonly used drug in the first-line treatment of human retinoblastoma (RB), but its clinical application is greatly limited due to acquired drug resistance upon the long-term treatment. Forkhead box protein M1 (FoxM1) is the transcription factor aberrantly expressed in various types of human cancers, which plays an essential ...
Xue, Zhu +7 more
openaire +2 more sources
Exercise serum regulates uric acid transporters in normal rat kidney cells
Scientific Reports, 2022 Hyperuricemia (HUA) refers to a physiological condition of high serum uric acid (SUA) level in the body, which may cause an increased risk of several chronic diseases. The kidney’s impaired uric acid (UA) metabolism is an important reason for HUA.
Zhongye Jiang +6 more
doaj +1 more source
Aging Cell, Volume 24, Issue 11, November 2025.DP1 receptor blockade attenuates microglial senescence and cognitive decline caused by PTGDS in exosomes from aged brains. ABSTRACT Aging leads to neurodegenerative diseases, such as cognitive decline, which are induced by persistent chronic low‐grade inflammation in the brain driven by microglial activation.
Yaru Liu +12 more
wiley +1 more source
Epilepsia, Volume 66, Issue 10, Page 3769-3784, October 2025.Abstract Objective Drug‐resistant epilepsy (DRE) affects >25 million people worldwide and is often associated with neuroinflammation. Increasing evidence links deficiency or malfunctioning of the enzyme phosphoglycerate dehydrogenase (PHGDH), which converts 3‐phosphoglycerate to generate serine and the neurotransmitter glycine, with (drug‐resistant ...
Karin Thevissen +25 more
wiley +1 more source