Results 61 to 70 of about 6,676 (188)

An unexpected protein interaction promotes drug resistance in leukemia

Nature Communications, 2017
ABCC4 is a chemotherapeutic drug exporter highly expressed in acute myeloid leukemia. Here, the authors demonstrate that MPP1 anchors ABCC4 to the outer cell membrane mediating drug resistance in leukemic cells and identify antimycin A as a chemical ...
Aaron Pitre, Yubin Ge, Wenwei Lin, Yao Wang, Yu Fukuda, Jamshid Temirov, Aaron H. Phillips, Jennifer L. Peters, Yiping Fan, Jing Ma, Amanda Nourse, Chandrima Sinha, Hai Lin, Richard Kriwacki, James R. Downing, Tanja A. Gruber, Victoria E. Centonze, Anjaparavanda P. Naren, Taosheng Chen, John D. Schuetz   +19 more
doaj   +1 more source

Impact of NR1I2, adenosine triphosphate–binding cassette transporters genetic polymorphisms on the pharmacokinetics of ginsenoside compound K in healthy Chinese volunteers

Journal of Ginseng Research, 2019
Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate–binding cassette (ABC) transporter genes on the pharmacokinetics of CK in ...
Luping Zhou, Lulu Chen, Yaqin Wang, Jie Huang, Guoping Yang, Zhirong Tan, Yicheng Wang, Jianwei Liao, Gan Zhou, Kai Hu, Zhenyu Li, Dongsheng Ouyang   +11 more
doaj   +1 more source

Development of Human Membrane Transporters: Drug Disposition and Pharmacogenetics [PDF]

, 2015
Membrane transporters play an essential role in the transport of endogenous and exogenous compounds, and consequently they mediate the uptake, distribution, and excretion of many drugs. The clinical relevance of transporters in drug disposition and their
Knibbe, C.A.J. (Catherijne), Mooij, M.G. (Miriam), Nies, A.T. (Anne T.), Schaeffeler, E. (Elke), Schwab, M. (Matthias), Tibboel, D. (Dick), Wildt, S.N. (Saskia) de   +6 more
core   +5 more sources

Deconvoluting Gut Versus Liver Cytochrome P450 3A4 Function: Drug Probes, Biomarkers, and Tissue Biopsy

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Cytochrome P450 3A4 (CYP3A4) is an important drug‐metabolizing enzyme, whose function is impacted by age, sex, body weight, pregnancy, and disease. It is also the site of major drug interactions involving inhibition and induction. Because CYP3A4 is expressed in the intestine and liver, investigators have sought to study its function in both ...
David Rodrigues
wiley   +1 more source

The androgen receptor controls expression of the cancer-associated sTn antigen and cell adhesion through induction of ST6GalNAc1 in prostate cancer. [PDF]

, 2015
This is the final version of the article. Available from Impact Journals via the DOI in this record.Patterns of glycosylation are important in cancer, but the molecular mechanisms that drive changes are often poorly understood.
Crundwell, M, Elliott, DJ, Floros, VI, Harries, LW, Johannessen, B, Knight, B, Leung, HY, Livermore, KE, McCullagh, P, McGrath, J, Mills, IG, Munkley, J, Oltean, S, Rajan, P, Robson, CN, Skotheim, RI, Star, E, Vodák, D, Wilson, BT, Zhou, Y   +19 more
core   +4 more sources

Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas, Shobana John, Murshadul Alam Murad, Chonlaphat Sukasem   +3 more
wiley   +1 more source

Inhalable delivery of AAV-based MRP4/ABCC4 silencing RNA prevents monocrotaline-induced pulmonary hypertension

Molecular Therapy: Methods & Clinical Development, 2015
The ATP-binding cassette transporter MRP4 (encoded by ABCC4) regulates membrane cyclic nucleotides concentrations in arterial cells including smooth muscle cells.
Caroline Claude, Nathalie Mougenot, Julia Bechaux, Lahouaria Hadri, Damian Brockschnieder, Michel Clergue, Fabrice Atassi, Anne-Marie Lompré, Jean-Sébastien Hulot   +8 more
doaj   +1 more source

Modulation of cAMP metabolism for CFTR potentiation in human airway epithelial cells

Scientific Reports, 2021
Cystic fibrosis (CF) is a genetic disease characterized by CF transmembrane regulator (CFTR) dysfunction. With over 2000 CFTR variants identified, in addition to known patient to patient variability, there is a need for personalized treatment.
Jenny P. Nguyen, Matthew Bianca, Ryan D. Huff, Nicholas Tiessen, Mark D. Inman, Jeremy A. Hirota   +5 more
doaj   +1 more source

Effects of cAMP and CFTR modulation on apical fluid pH in human airway Calu‐3 cells

Physiological Reports, Volume 14, Issue 3, February 2026.
Abstract The airway epithelium serves as the first line of defense against inhaled insults present in the external environment by acting as a physical barrier and through host defense mechanisms. Proper maintenance of these host defense mechanisms relies on the regulation of airway surface liquid (ASL) composition and properties, a process that is ...
Jenny P. Nguyen, Nadia Milad, Jeremy A. Hirota   +2 more
wiley   +1 more source

Differential Regulation of Hepatic Cholesterol Metabolism by Water Extract or Residue of Large‐Leaf Yellow Tea in High‐Fat Diet‐Fed Mice

Food Frontiers, Volume 7, Issue 1, January 2026.
This study investigates the lipid metabolism regulatory effects of large‐leaf yellow tea (YT), its aqueous extract (YAE), and its tea residue (YSR) in a high‐fat diet‐induced mouse model. we evaluated their effects on serum lipid metabolism indices and explored potential mechanisms of intervention through transcriptome analysis.
Yuzhu Shen, Denghuan Luo, Fengjuan Lu, Rongrong Dong, Xiaochun Wan, Yijun Wang, Hongyan Wang, Ying Zhang, Jun Chu, Jinbao Huang, Na Xu   +10 more
wiley   +1 more source