Results 71 to 80 of about 3,461 (145)

Stabilization of Human Multidrug Resistance Protein 4 (MRP4/ABCC4) Using Novel Solubilization Agents [PDF]

SLAS Discovery, 2019
Membrane proteins (MPs) are important drug discovery targets for a wide range of diseases. However, elucidating the structure and function of native MP is notoriously challenging as their original structure has to be maintained once removed from the lipid bilayer.
David Hardy, Roslyn M. Bill, Alice J. Rothnie, Anass Jawhari   +3 more
openaire   +3 more sources

Colorectal Neoplasia Pathogenesis in Normal Appearing Colonic Mucosa ‐A Perspective With Focus on Eicosanoid Signaling Pathways

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Colorectal cancer (CRC) is a major cause of cancer‐related mortality, especially in the Western world, and its incidence is expected to increase in the years to come. Prevention and early detection are key strategies to improve CRC morbidity and mortality.
Ulrike Ries Feddersen, Sebastian Kjærgaard Hendel, Victoria Hellen Berner‐Hansen, Simon Veedfald, Mark Berner‐Hansen, Niels Bindslev   +5 more
wiley   +1 more source

Perinatal Maturation of Drug Transporters and Claudin‐5 at the Blood–Brain Barrier

CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.
P‐gp expression in the developping human cortex increases with age. In the mouse, gatekeepers of BBB integrity and transport are upregulated: tighter blood–brain barrier, increased claudin 5/Slco1a4/P‐gp expression as well as enhanced P‐gp‐mediated BBB efflux.
Laetitia Federici, Salvatore Cisternino, Sylvain Auvity, Antoinette Gelot, Mathilde Becmeur‐Lefebvre, Maryline Favier, Gaelle Letort, Philippe Mailly, Martine Cohen‐Salmon, Anne‐Cécile Boulay   +9 more
wiley   +1 more source

Genetic Ablation of the ABC Transporter Abcc4 Impairs Lymphoid Leukemogenesis

The FASEB Journal, 2018
ABCC4 is an ABC transporter of the C sub‐family that is ubiquitously expressed and exports key endogenous compounds including cAMP and prostaglandins, and cancer chemotherapeutic drugs. cAMP and prostaglandins are signaling molecules that, among other functions, regulate thymocyte development and function.
Rebecca R. Crawford, Satish Cheepala, Shangli Lian, Yu Fukuda, Yao Wang, John D. Schuetz   +5 more
openaire   +1 more source

Matching maternal and paternal experiences underpin molecular thermal acclimation

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract The environment experienced by one generation has the potential to affect the subsequent one through non‐genetic inheritance of parental effects. Since both mothers and fathers can influence their offspring, questions arise regarding how the maternal, paternal and offspring experiences integrate into the resulting phenotype.
L. C. Bonzi, J. M. Donelson, R. K. Spinks, P. L. Munday, T. Ravasi, C. Schunter   +5 more
wiley   +1 more source

A Single-Nucleotide Polymorphism in ABCC4 Is Associated with Tenofovir-Related Beta2-Microglobulinuria in Thai Patients with HIV-1 Infection.

PLoS ONE, 2016
BackgroundIn Thailand, the combined generic anti-retroviral drug stavudine/lamivudine/nevirapine (d4T/3TC/NVP) has been used to treat human immunodeficiency virus (HIV)-infected individuals since 2001.
Sirirat Likanonsakul, Bussakorn Suntisuklappon, Ravee Nitiyanontakij, Wisit Prasithsirikul, Emi E Nakayama, Tatsuo Shioda, Chariya Sangsajja   +6 more
doaj   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, Volume 15, Issue 7, Page 1159-1175, July 2025.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Natural Antioxidants as Regulators of Circular RNA Expression and Function

WIREs RNA, Volume 16, Issue 4, July/August 2025.
Natural antioxidants found in food can modulate circular RNA activity, offering a novel strategy to counteract oxidative stress and its related diseases, including cardiovascular disorders, diabetes, and cancer. This emerging connection between diet and gene regulation holds promising potential for both therapy and prevention.
Aseela Fathima, Shadiya Fawzu Ameer, Rabia Ilhem Kerzabi, Roberta Giordo, Gheyath K. Nasrallah, Hatem Zayed, Gianfranco Pintus   +6 more
wiley   +1 more source

Analysis of the membrane proteome of ciprofloxacin-resistant macrophages by stable isotope labeling with amino acids in cell culture (SILAC).

PLoS ONE, 2013
Overexpression of multidrug transporters is a well-established mechanism of resistance to chemotherapy, but other changes may be co-selected upon exposure to drugs that contribute to resistance.
Nancy E Caceres, Maarten Aerts, Béatrice Marquez, Marie-Paule Mingeot-Leclercq, Paul M Tulkens, Bart Devreese, Françoise Van Bambeke   +6 more
doaj   +1 more source

A Role for ABCC4 in Regulating Pigment Granule Aggregation in Mice

The FASEB Journal, 2019
ABCC4 is member of the family of ATP‐binding cassette proteins that specialize in transporting a variety of molecules out of the cell. ABCC4 exports signaling molecules present in the retina, including cyclic adenosine monophosphate (cyclic AMP).
Thomas Mireles, Dora Evelyn Ibarra, Emely Reimer Wiebe, Amanda M Pattillo, Cody J Rodriguez, John D Schuetz, Dana M García   +6 more
openaire   +1 more source