Results 71 to 80 of about 6,676 (188)

Differential Expression of ABC Transporter Genes in Brain Vessels vs. Peripheral Tissues and Vessels from Human, Mouse and Rat

Pharmaceutics, 2023
Background: ATP-binding cassette (ABC) transporters comprise a superfamily of genes encoding membrane proteins with nucleotide-binding domains (NBD).
Wandong Zhang, Qing Yan Liu, Arsalan S. Haqqani, Ziying Liu, Caroline Sodja, Sonia Leclerc, Ewa Baumann, Christie E. Delaney, Eric Brunette, Danica B. Stanimirovic   +9 more
doaj   +1 more source

Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma [PDF]

BioMed Research International, 2013
Ovarian cancer is the main cause of death from gynaecological malignancies. In spite of the efficacy of platinum-paclitaxel treatment in patients with primary epithelial ovarian carcinoma, platinum-based chemotherapy is not curative and resistance remains one of the most important causes of treatment failure.
M. Bagnoli, G. L. Beretta, L. Gatti, S. Pilotti, P. Alberti, E. Tarantino, M. Barbareschi, S. Canevari, D. Mezzanzanica, P. Perego   +9 more
openaire   +3 more sources

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Gene expression profile of ABC transporters and cytotoxic effect of ibuprofen and acetaminophen in an epithelial ovarian cancer cell line in vitro [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2015
PURPOSES: To determine the basic expression of ABC transporters in an epithelial ovarian cancer cell line, and to investigate whether low concentrations of acetaminophen and ibuprofen inhibited the growth of this cell line in vitro.
Renilton Aires Lima, Eduardo Batista Cândido, Flávia Perrim de Melo, Josiane Barbosa Piedade, Paula Vieira Teixeira Vidigal, Luciana Maria Silva, Agnaldo Lopes da Silva Filho   +6 more
doaj   +1 more source

Population Pharmacokinetic and Pharmacodynamic Analysis of Voriconazole‐Induced Liver Injury in Chinese Lung Transplant Patients

Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Background Voriconazole (VCZ) served as primary therapy for invasive aspergillosis in lung transplant recipients. However, VCZ‐induced hepatotoxicity emerged as a frequent adverse effect that critically compromised postoperative management and complication prevention in this vulnerable population.
Dan Zhang, Wenwen Du, Wei Qin, Bo Li, Pengmei Li, Xiaoxing Wang, Wenqian Chen, Anjali Chauhan   +7 more
wiley   +1 more source

A burst of ABC genes in the genome of the polyphagous spider mite Tetranychus urticae [PDF]

, 2013
Background: The ABC (ATP-binding cassette) gene superfamily is widespread across all living species. The majority of ABC genes encode ABC transporters, which are membrane-spanning proteins capable of transferring substrates across biological membranes by
Edward Osborne, Luc Tirry, Miodrag Grbić, Richard M Clark, Thomas Van Leeuwen, Wannes Dermauw   +5 more
core   +4 more sources

Crucial Role for Phylogenetically Conserved Cytoplasmic Loop 3 in ABCC4 Protein Expression [PDF]

Journal of Biological Chemistry, 2013
The ABC transporter ABCC4 is recognized as an ATP-dependent exporter of endogenous substances as well as an increasing variety of anionic chemotherapeutics. A loss-of-function variant of zebrafish Abcc4 was identified with a single amino acid substitution in the cytoplasmic loop T804M. Because this substituted amino acid is highly conserved among ABCC4
Satish B, Cheepala, Ju, Bao, Deepa, Nachagari, Daxi, Sun, Yao, Wang, Tao P, Zhong, Tao, Zhong, Anjaparavanda P, Naren, Jie, Zheng, John D, Schuetz   +9 more
openaire   +3 more sources

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, Volume 19, Issue 12, Page 3729-3749, December 2025.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes. [PDF]

, 2017
ObjectiveTo determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples.MethodsFor this study ...
Barcellos, Lisa F, Cole, Michael, Criswell, Lindsey A, Firestein, Gary S, Graf, John, Halperin, Eran, Harrison, Ruby, Holingue, Calliope, Link, Thomas, Quach, Diana, Quach, Hong L, Rahmani, Elior, Rhead, Brooke, Shah, Khooshbu, Shao, Xiaorong, Sinclair, Elizabeth, Wang, Wei   +16 more
core   +1 more source

Lamivudine and tenofovir pharmacokinetic variability in people with HIV in Papua New Guinea

British Journal of Clinical Pharmacology, Volume 91, Issue 12, Page 3412-3421, December 2025.
Aims Demographics and kidney function contribute to variability in lamivudine and tenofovir drug concentrations. The aim was to assess, for the first time, the pharmacokinetic variability of lamivudine and tenofovir in Papua New Guinean (PNG) HIV/AIDS patients.
Natália Bordin Andriguetti, Daniel Thomas Barratt, Joseph Tucci, Paul Pumuye, Andrew Alexander Somogyi   +4 more
wiley   +1 more source