Results 31 to 40 of about 3,094 (152)

The molecular and physiological roles of ABCC6: more than meets the eye

Frontiers in Genetics, 2012
Abnormal mineralization occurs in the context of several common conditions, including advanced age, diabetes, hypercholesterolemia, chronic renal failure and certain genetic conditions. Metabolic, mechanical, infectious, and inflammatory injuries promote
Olivier eLe Saux, Ludovic eMartin, Zouhair eAherrahrou, Georges eLeftheriotis, Andras eVaradi, Christopher N. Brampton   +5 more
doaj   +1 more source

Abcc6 Null Mice—a Model for Mineralization Disorder PXE Shows Vertebral Osteopenia Without Enhanced Intervertebral Disc Calcification With Aging

Frontiers in Cell and Developmental Biology, 2022
Chronic low back pain is a highly prevalent health condition intricately linked to intervertebral disc degeneration. One of the prominent features of disc degeneration that is commonly observed with aging is dystrophic calcification. ATP-binding cassette
Paige K. Boneski, Vedavathi Madhu, Ryan E. Tomlinson, Irving M. Shapiro, Koen van de Wetering, Makarand V. Risbud   +5 more
doaj   +1 more source

Clinical Significance and Potential Mechanisms of ATP Binding Cassette Subfamily C Genes in Hepatocellular Carcinoma

Frontiers in Genetics, 2022
The purpose of this investigation was to assess the diagnostic and prognostic significance of ATP binding cassette subfamily C (ABCC) genes in hepatocellular carcinoma (HCC).
Xin Zhou, Xin Zhou, Jia-mi Huang, Jia-mi Huang, Tian-man Li, Tian-man Li, Jun-qi Liu, Jun-qi Liu, Zhong-liu Wei, Zhong-liu Wei, Chen-lu Lan, Chen-lu Lan, Guang-zhi Zhu, Guang-zhi Zhu, Xi-wen Liao, Xi-wen Liao, Xin-ping Ye, Xin-ping Ye, Tao Peng, Tao Peng   +19 more
doaj   +1 more source

Regulation of ABCC6 trafficking and stability by a conserved C-terminal PDZ-like sequence.

PLoS ONE, 2014
Mutations in the ABCC6 ABC-transporter are causative of pseudoxanthoma elasticum (PXE). The loss of functional ABCC6 protein in the basolateral membrane of the kidney and liver is putatively associated with altered secretion of a circulatory factor. As a
Peng Xue, Chelsea M Crum, Patrick H Thibodeau   +2 more
doaj   +1 more source

ABCC6 plays a significant role in the transport of nilotinib and dasatinib, and contributes to TKI resistance in vitro, in both cell lines and primary patient mononuclear cells.

PLoS ONE, 2018
ATP Binding Cassette family efflux proteins ABCB1 and ABCG2 have previously been demonstrated to interact with Tyrosine Kinase Inhibitors (TKIs); however, evidence for the interaction of other potentially relevant drug transporters with TKIs is lacking ...
Laura N Eadie, Phuong Dang, Jarrad M Goyne, Timothy P Hughes, Deborah L White   +4 more
doaj   +1 more source

From Clinical Diagnosis to the Discovery of Multigene Rare Sequence Variants in Pseudoxanthoma elasticum: A Case Report

Frontiers in Medicine, 2021
Pseudoxanthoma elasticum (PXE) is a rare autosomal recessive disease clinically characterised by early cutaneous alterations, and by late clinically relevant ocular, and cardiovascular manifestations.
Francesco Demetrio Lofaro, Dario Pasquale Mucciolo, Vittoria Murro, Laura Pavese, Daniela Quaglino, Federica Boraldi   +5 more
doaj   +1 more source

ABCC6 knockdown in HepG2 cells induces a senescent-like cell phenotype

Cellular & Molecular Biology Letters, 2017
Background Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective treatment exists.
Rocchina Miglionico, Angela Ostuni, Maria Francesca Armentano, Luigi Milella, Elvira Crescenzi, Monica Carmosino, Faustino Bisaccia   +6 more
doaj   +1 more source

Is ABCC6 a genuine mitochondrial protein? [PDF]

, 2013
BACKGROUND: A recent article in Circulation Research suggests that the protein ABCC6, which when defective is responsible for pseudoxanthoma elasticum, an inherited condition with skin, eye and cardiovascular manifestations, is associated with ...
D. Henrion, Henrion, Daniel, Lefthériotis, Georges, Ferré, Marc, Prunier-Mirebeau, Delphine, D. Bonneau, V. Procaccio, A. Chevrollier, Bonneau, Dominique, Procaccio, Vincent, M. Ferré, P. Reynier, Martin, Ludovic, D. Mirebeau-Prunier, L. Martin, Reynier, Pascal, G. Lefthériotis, Chevrollier, Arnaud, Delphine Prunier-Mirebeau, Vincent Procaccio, Marc Ferré, Pascal Reynier, Ludovic Martin, Arnaud Chevrollier, Daniel Henrion, Dominique Bonneau, Georges Lefthériotis   +26 more
core   +1 more source

Mouse models for pseudoxanthoma elasticum: genetic and dietary modulation of the ectopic mineralization phenotypes.

PLoS ONE, 2014
Pseudoxanthoma elasticum (PXE), a heritable ectopic mineralization disorder, is caused by mutations in the ABCC6 gene. Null mice (Abcc6(-/-) ) recapitulate the genetic, histopathologic and ultrastructural features of PXE, and they demonstrate early and ...
Qiaoli Li, Haitao Guo, David W Chou, Annerose Berndt, John P Sundberg, Jouni Uitto   +5 more
doaj   +1 more source

Quantification of the Calcification Phenotype of Abcc6-Deficient Mice with Microcomputed Tomography [PDF]

, 2012
Pseudoxanthoma elasticum in humans and dystrophic cardiac calcification in mice are heritable disorders characterized by dystrophic calcification of soft connective tissues related to the defective function of the ABCC6 (human)/Abcc6 (mouse) transporter.
Le Corre, Yannick, Lefthériotis, Georges, Marchand-Libouban, Hélène, Kauffenstein, Gilles, Y. Le Corre, O. Le Saux, G. Kauffenstein, H. Marchand-Libouban, Froeliger, Florence, Le Saux, Olivier, Martin, Ludovic, L. Martin, F. Froeliger, S. Willoteaux, G. Lefthériotis, Willoteaux, Serge   +15 more
core   +1 more source