Results 51 to 60 of about 2,873 (186)

ABCC6- a new player in cellular cholesterol and lipoprotein metabolism? [PDF]

Lipids in Health and Disease, 2014
Dysregulations in cholesterol and lipid metabolism have been linked to human diseases like hypercholesterolemia, atherosclerosis or the metabolic syndrome. Many ABC transporters are involved in trafficking of metabolites derived from these pathways.
Kuzaj, Patricia, Kuhn, Joachim, Dabisch-Ruthe, Mareike, Faust, Isabel (Dr. rer. nat.), Götting, Christian, Knabbe, Cornelius (Prof. Dr. med.), Hendig, Doris (Dr. rer. nat.)   +6 more
openaire   +3 more sources

CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease

Cells, 2022
Moyamoya disease (MMD) is an occlusive, chronic cerebrovascular disease affected by genetic mutation and the immune response. Furthermore, vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) participate in the neointima of MMD, but the ...
Yuan Liu, Yimin Huang, Xincheng Zhang, Xiaopeng Ma, Xuejun He, Chao Gan, Xin Zou, Sheng Wang, Kai Shu, Ting Lei, Huaqiu Zhang   +10 more
doaj   +1 more source

ABCC6 Transporter Contributed to Cisplatin Resistance on Bladder Cancer. [PDF]

Int J Med Sci
Bladder cancer (BLCA) is one of the most common urological malignancies worldwide, including in Taiwan, where its incidence has been increasing. It accounts for approximately 3% of all newly diagnosed cancer cases. Drug resistance remains a major challenge in BLCA treatment, particularly at the metastatic stage, where only 35% of metastatic BLCA ...
Chou KY, Chang AC, Hwang TI, Tsai TF, Ho CY, Liu HW, Achudhan D, Tang CH, Lin YY.   +8 more
europepmc   +4 more sources

弾性線維性仮性黄色腫を有する日本人患者76人における臨床症状とABCC6遺伝子変異の解析

, 2017
Pseudoxanthoma elasticum (PXE) is a hereditary disease, causing calcification and degeneration of elastic fibers, which affects the skin, eye, cardiovascular systems and gastrointestinal tract. PXE is caused by mutations in the ABCC6 gene.
岩永, 聰
core   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

ABCC6 gene polymorphism associated with variation in plasma lipoproteins [PDF]

Journal of Human Genetics, 2001
The ATP cassette-binding (ABC) gene superfamily contains more than 40 members, many of which are involved in cellular lipid transport. The most prominent example is ABCA1, mutations in which affect plasma high-density lipoprotein (HDL) cholesterol concentration.
J, Wang, S, Near, K, Young, P W, Connelly, R A, Hegele   +4 more
openaire   +2 more sources

The ABCC6 transporter: what lessons can be learnt from other ATP-binding cassette transporters?

Frontiers in Genetics, 2013
ABC transporters represent a large family of ATP-driven transmembrane transporters involved in uni- or bidirectional transfer of a variety of substrates.
Olivier M. Vanakker, Mohammad Jakir Hosen, Anne eDe Paepe   +2 more
doaj   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Therapeutic Strategies to Overcome Payload Resistance of Trastuzumab Deruxtecan in HER2‐Positive Cancers

Cancer Science, Volume 117, Issue 4, Page 996-1009, April 2026.
Overexpression of ABC transporters, especially ABCG2 and ABCB1, mediates acquired resistance to T‐DXd in HER2‐positive cancers. Inhibition of these transporters restored T‐DXd efficacy, highlighting efflux‐mediated resistance as a potential therapeutic target. ABSTRACT Antibody–drug conjugates (ADCs) are emerging as a promising class of targeted cancer
Yuya Murase, Shigeki Nanjo, Sachiko Arai, Sota Kondo, Hayato Koba, Yifeng Liu, Koji Fukuda, Shigeki Sato, Jun Kinoshita, Noriyuki Inaki, Tsukasa Ueda, Shunichi Nomura, Yuichi Tambo, Takahiro Shimizu, Masafumi Horie, Daichi Maeda, Richard W. Wong, Kazuyoshi Hosomichi, Takafumi Kobayashi, Satoshi Watanabe, Kenta Yamamura, Noriyuki Ohkura, Miki Abo, Seiji Yano   +23 more
wiley   +1 more source

Impact of the C-terminus on ABCC6 degradation.

, 2014
ABCC6 degradation was evaluated after treatment with a proteasome inhibitor (lactacystin) or a combination of lysosomal protease inhibitors, (leupeptin and pepstatin) and assessed by western blotting.
Patrick H. Thibodeau (565940), Chelsea M. Crum (565939), Peng Xue (219948)   +2 more
core   +1 more source