Results 51 to 60 of about 3,094 (152)

Atherogenic Diet Accelerates Ectopic Mineralization in a Mouse Model of Pseudoxanthoma Elasticum

International Journal of Dermatology and Venerology, 2020
. Objective:. Pseudoxanthoma elasticum (PXE) is a multisystem heritable disorder caused by mutations in the Abcc6 gene. The disease is characterized by ectopic mineralization of the skin, eyes, and arterial blood vessels. Previous studies have suggested
Jing-Yi Zhao, Joshua Kingman, Ida Joely Jacobs, Jouni Uitto, Yi Cao, Qiao-Li Li   +5 more
doaj   +1 more source

Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All‐Cause Mortality

Aging Cell, Volume 25, Issue 10, October 2026.
We benchmarked 23 ageing biomarkers and 9703 protein targets for associations with mortality risk. Epigenetic, neuroimaging and functional biomarkers showed the strongest associations, outperforming proteomic organ clocks. Among 368 mortality‐associated proteins, high‐risk proteins were enriched in immune functions, whereas low‐risk proteins were ...
Maira Pyrgioti, Ines Mesa Eguiagaray, Paul Redmond, Janie Corley, Mark E. Bastin, Maria Valdés Hernández, Tom C. Russ, Joanna M. Wardlaw, Eilis Hannon, Ian J. Deary, Keenan A. Walker, Elliot M. Tucker‐Drob, Simon R. Cox, Riccardo E. Marioni, Sarah E. Harris   +14 more
wiley   +1 more source

Temperature dependence of HCN channel kinetics: A systematic comparison across mammalian isoforms and species

Experimental Physiology, Volume 111, Issue 10, Page 4659-4687, 1 October 2026.
Abstract Hyperpolarization‐activated, cyclic nucleotide‐gated (HCN) channels are important regulators of cardiac pacemaking and neuronal excitability, yet their temperature dependence has not been compared systematically across mammalian isoforms and species in standardized experimental conditions. Here, we performed a standardized electrophysiological
Rajnish Ranjan, Emmanuelle Logette, Mirjia Herzog, Valerie Buchillier, Enrico Scantamburlo, Henry Markram   +5 more
wiley   +1 more source

Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Calcium phosphate biomineralization has traditionally been considered a protein‐regulated process. This review highlights the emerging role of nucleic acids, which interact with mineral phases through adsorption, coprecipitation, and templating, thereby influencing crystal nucleation and growth.
Fanny Duhalde, Jessem Landoulsi, Xavier Houard   +2 more
wiley   +1 more source

ABCC6 Gene Analysis in 20 Japanese Patients with Angioid Streaks Revealing Four Frequent and Two Novel Variants and Pseudodominant Inheritance

Journal of Ophthalmology, 2017
Purpose. To report the spectrum of ABCC6 variants in Japanese patients with angioid streaks (AS). Patients and Methods. This was a single-center cohort study.
Satoshi Katagiri, Yuya Negishi, Kei Mizobuchi, Mitsuyoshi Urashima, Tadashi Nakano, Takaaki Hayashi   +5 more
doaj   +1 more source

Abcc6 deficiency in mice leads to altered ABC transporter gene expression in metabolic active tissues

Lipids in Health and Disease, 2019
Background ATP-binding cassette (ABC) transporters are involved in a huge range of physiological processes. Mutations in the ABCC6 gene cause pseudoxanthoma elasticum, a metabolic disease with progressive soft tissue calcification. Methods The aim of the
Bettina Ibold, Isabel Faust, Janina Tiemann, Theo G. M. F. Gorgels, Arthur A. B. Bergen, Cornelius Knabbe, Doris Hendig   +6 more
doaj   +1 more source

Abcc6 deficiency prevents rhabdomyolysis-induced acute kidney injury

Scientific Reports, 2023
Rhabdomyolysis is a risk factor for acute kidney injury, transition towards chronic kidney disease, and death. The role of calcium phosphate deposits in the mechanisms of rhabdomyolysis-induced acute kidney injury (RAKI) is still unclear.
Audrey Casemayou, Julie Belliere, Emmanuel Letavernier, Eloïse Colliou, Hélène El Hachem, Jeremy Zarowski, Dominique Bazin, Clément Kounde, Alexis Piedrafita, Guylène Feuillet, Joost P. Schanstra, Stanislas Faguer   +11 more
doaj   +1 more source

A Novel Idiopathic Atrial Calcification: Pathologic Manifestations and Potential Mechanism

Frontiers in Cardiovascular Medicine, 2022
BackgroundCardiac calcification is a type of ectopic pathologic calcification of unknown etiology and mechanisms. Once diagnosed, the location, extent and morphology of the calcified lesions, as well as their functional significance in the heart, are ...
Bowen Li, Bowen Li, Qingbo Liu, Xihui Chen, Xihui Chen, Tangdong Chen, Tangdong Chen, Wenhui Dang, Jing Zhao, Guangbin Cui, Kun Chen, Yuanming Wu, Yuanming Wu   +12 more
doaj   +1 more source

Protective Effect of Phytic Acid in Cardiovascular Diseases: A Systematic Review

ChemFoodChem, Volume 2, Issue 3, September 2026.
ABSTRACT Cardiovascular diseases (CVDs) are a cluster of ailments that impact the heart and blood vessels and are a primary public health problem of mortality on a global scale. Phytic acid, a dietary constituent frequently present in foods like seeds, has been linked to many pharmacological attributes, including anti‐cancer, antioxidant, anti ...
Marta M. S. de Freitas Almeida, Éverton A. Pereira, Patricia Severino, Cristina Blanco‐Llamero, Sandra L. Santos, Luciana N. Andrade, Ricardo G. Amaral, Eliana B. Souto   +7 more
wiley   +1 more source

Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum.

, 2005
Contains fulltext : 32422.pdf (Publisher’s version ) (Open Access)Pseudoxanthoma elasticum (PXE) is a heritable disorder of connective tissue, affecting mainly skin, eye and the cardiovascular system.
Levelt, C.C., Toonstra, J., Gorgels, T.G., Jong, P.T.V.M. de, Peek, R., Kuppevelt, A.H.M.S.M. van, Hu, X., Bergen, A.A.B., Scheper, R.J., Scheffer, G.L., Wolf, A., Wal, A. van der, Loves, W.J.   +12 more
core   +1 more source