Results 91 to 100 of about 509,731 (381)

m-FISH analysis reveals complexity of chromosome aberrations in individuals occupationally exposed with internal plutonium: A pilot study to assess the relevance of complex aberrations as biomarkers of exposure to high-LET α particles [PDF]

, 2005
We recently demonstrated that a significant proportion of apparently stable insertions induced after exposure to a mean of 1 α particle/cell, detected using 3-colour FISH, were part of larger unstable complexes when visualised by 24-colour FISH ...
Anderson, RM, Gasteva, GN, Goodhead, DT, Molokanov, AV, Sevankaev, AV, Tsepenko, VV   +5 more
core  

High-order aberration compensation with Multi-frame Blind Deconvolution and Phase Diversity image restoration techniques

, 2010
Context. For accurately measuring intensities and determining magnetic field strengths of small-scale solar (magnetic) structure, knowledge of and compensation for the point spread function is crucial.
Dai, Danilovic, Fried, G. B. Scharmer, J. de la Cruz Rodriguez, Lagg, Löfdahl, M. G. Löfdahl, Mathew, Nordlund, Paxman, Paxman, Puschmann, Rouppe van der Voort, Scharmer, Scharmer, Stein, Stevens, T. I. M. van Werkhoven, Uitenbroek, van Noort, Veran, Wedemeyer-Böhm, Wedemeyer-Böhm   +23 more
core   +1 more source

No increase in radiation-induced chromosome aberration complexity detected by m-FISH after culture in the presence of 5’-bromodeoxyuridine [PDF]

, 2006
The thymidine analogue, 5’-bromodeoxyuridine (BrdU), is a known mutagen that is routinely introduced into culture media for subsequent Harlequin stain analysis and determination of cell cycle status.
Anderson, Anderson, Anderson, Anderson, Boei, Cornforth, Dresp, Dudley T. Goodhead, Edwards, George, Goodhead, Griffin, Hawkins, Hsu, Iliakis, Kolin-Gerresheim, Latt, Leonard, Lloyd, Lorimore, Lucas, Moquet, Morimoto, Morton, Natalia D. Sumption, Pala, Perry, Ramsey, Rhona M. Anderson, Ritter, Sachs, Savage, Savage, Schmid, Scott, Simpson, Singleton, Tice, Wang   +38 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Ray and Wave Aberrations Revisited: A Huygens-Like Construction yields Exact Relations [PDF]

, 2015
The optical aberrations of a system can be described in terms of the wave aberrations, defined as the departure from the ideal spherical wavefront; or the ray aberrations, which are in turn the deviations from the paraxial ray intersection measured in ...
Ihrke, Ivo, Restrepo, John, Stoerck, Pawel J.   +2 more
core   +4 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Simultaneous versus sequential corneal cross-linking and intracorneal ring segments implantation for keratoconus: two-year study [PDF]

International Journal of Ophthalmology
AIM: To compare simultaneous corneal collagen cross-linking (CXL) with intracorneal ring segment (ICRS) implantation versus successive ICRS followed by CXL and detect the impact of the timing of CXL after ICRS implantation in the successive method ...
Ismail Omar, Rasha Safwat Elhiny
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Annular objective apertures improve resolution of electron microscopes [PDF]

, 1972
Hollow-cone illumination techniques, using an annular objective aperture located behind back focal plane of objective lens, increase image contrast and minimize chromatic ...
Heinemann, K., Poppa, H. R.
core   +1 more source