Results 81 to 90 of about 208,047 (254)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Higher order aberrations across the horizontal visual field

open access: yes, 2006
Errata: Higher order aberrations across the horizontal visual ...
Atchison, David A.
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Effects of age on peripheral ocular aberrations [PDF]

open access: yes, 2010
On-axis monochromatic higher-order aberrations increase with age. Few studies have been made of peripheral refraction along the horizontal meridian of older eyes, and none of their off-axis higher-order aberrations.
Mathur, Ankit   +4 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Visual Tasks Dependence of the Neural Compensation for the Keratoconic Eye's Optical Aberrations

open access: yesJournal of Optometry, 2010
Purpose: To investigate whether “normal” eyes viewing through keratoconic (KC) eye aberrations can achieve a similar visual performance (VP) to that of KC eyes. Method: We measured the high-contrast visual acuity (VA) and the 10, 15 and 20 c/deg contrast
Hélène Rouger   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Anterior corneal, posterior corneal, and lenticular contributions to ocular aberrations [PDF]

open access: yes, 2016
Purpose: To determine the corneal surfaces and lens contributions to ocular aberrations.\ud \ud Methods: There were 61 healthy participants with ages ranging from 20 to 55 years and refractions –8.25 D to +3.25 D.
Mathur, Ankit   +4 more
core   +1 more source

Evaluation of the Cytogenotoxic Effects of Emulsifiable Concentrate form of Amitraz Pesticide on Allium cepa L

open access: yesJournal of Applied Sciences and Environmental Management, 2019
The cytogenotoxic effects of emulsifiable concentrate of amitraz pesticides was evaluated using Allium cepa L. test. The root meristems of A. cepa L. were treated with five concentrations (1%, 5%, 10%, 20% and 40%) of the chemical pesticide at 48 h for ...
A.A Adesuyi   +6 more
doaj   +1 more source

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