Results 81 to 90 of about 334,949 (278)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Annular objective apertures improve resolution of electron microscopes [PDF]

, 1972
Hollow-cone illumination techniques, using an annular objective aperture located behind back focal plane of objective lens, increase image contrast and minimize chromatic ...
Heinemann, K., Poppa, H. R.
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Applying individual rigid scleral contact lenses in visual rehabilitation of patients with an irregular corneal surface. Clinical cases

Российский офтальмологический журнал
Scleral rigid contact lenses efficiently correct the vision of patients with irregular corneas. Purpose. To study the features of contact correction and visual rehabilitation of patients with irregular corneal surface using individual scleral rigid ...
A. V. Ivanova, A. S. Sklyarova, A. T. Khandzhyana, N. V. Khodzhabekyan, I. V. Manukyan   +4 more
doaj   +1 more source

Polarization Aberrations [PDF]

The analysis of the polarization characteristics displayed by optical systems can be divided into two categories: geometrical and physical. Geometrical analysis calculates the change in polarization of a wavefront between pupils in an optical instrument.
Chipman, Russell A., Mcguire, James P., Jr.   +1 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Comparison of coronagraphs for high contrast imaging in the context of Extremely Large Telescopes

, 2008
We compare coronagraph concepts and investigate their behavior and suitability for planet finder projects with Extremely Large Telescopes (ELTs, 30-42 meters class telescopes).
A. Boccaletti, Abe, Aime, Aime, Aller Carpentier, Baba, Baudoz, Baudoz, Baudoz, Beuzit, C. Cavarroc, C. Vérinaud, Cavarroc, Chanan, Crepp, Dierickx, Gilmozzi, Guyon, Guyon, Guyon, Guyon, Johns, Kuchner, Kuchner, Lyot, M. Kasper, Marois, Marois, Martinez, Martinez, Mawet, N. Yaitskova, Nelson, P. Martinez, Racine, Riaud, Rouan, Sivaramakrishnan, Soummer, Soummer, Soummer, T. Fusco, Vanderbei, Yaitskova   +43 more
core   +4 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source