Results 61 to 70 of about 307,093 (281)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
“That Sottish and Selfish principle”: Cugoano on Self-Interest, Imagination, and Moral Wrongdoing
Journal of Modern PhilosophyThe following paper analyzes Ottobah Cugoano’s argument against the type of moral wrongdoing of those who participated in the practices of the transatlantic slave trade and of enslavement. I will argue that Cugoano describes moral wrongdoing in a general
Aminah Hasan-Birdwell
doaj +2 more sources
Abandonment of land and the Scottish Coal case : was it Unprecedented? [PDF]
, 2018 The support of the Carnegie Trust for the Universities of Scotland in the provision of a research incentive grant that contributed to this note is gratefully acknowledged.Peer ...
Combe, Malcolm, Rudd, Malcolm I.
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Evangélisme et politique dans la jeune République
Transatlantica, 2006 Since the emergence of ethno‑historical studies in the 1960s and 70s suggesting a link between religious affiliation and electoral behavior during the early republic and the antebellum period, historiographies of religious and political culture have both
Lucia Bergamasco
doaj +1 more source
Incidents in the Life of a Slave Girl, Education and Abolition [PDF]
, 2009 Some thirty years before Harriet Ann Jacobs opened the Jacobs Free School in Alexandria, Virginia in January 1864, one of her first students was her fifty-threeyear-old uncle, Fred.
Baumgartner, Kabria
core +2 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Social SciencesSince the era of chattel slavery, the state has used institutionalized abuse and violence as a tool for reproductive control. Today, public institutions and social services have been established by the state to police and surveil the behavior of poor ...
Maya Pendleton, Alan J. Dettlaff
doaj +1 more source
European perspective and legal framework of death penalty [PDF]
Izzivi Prihodnosti, 2016 Purpose and Originality: The purpose of this research is to find out what is European union doing for the abolition of the death Method: We used analytical and descriptive method and collected data mainly from EU´s online official sources on legal ...
Rudolf Hnidka
doaj
Use of apomorphine in Parkinsonian patients with neuropsychiatric complications to oral treatment [PDF]
, 1997 Neuropsychiatric side effects often complicate anti-Parkinsonian therapy and pose a significant problem in the optimal management of idiopathic Parkinson's disease.
Abbott, R.J. +6 more
core +2 more sources