Results 151 to 160 of about 3,204 (212)

Determination of Abrin by a Magnetic Affinity Immunoassay (MAIA) Based on the Signal Amplification of the Aptamer and Staphylococcal Protein A (SPA) Functionalized Gold Magnetic Microparticles (GMPs)

Analytical Letters, 2022
A new magnetic affinity immunoassay (MAIA) was developed for the determination of abrin based on signal amplification of staphylococcal protein A (SPA) functionalized gold magnetic microparticles (GMPs) and the aptamer. This assay consisted of a sandwich
Xihui Mu, Bin Du, Houfang Liu, Chuan Gao, Zhiwei Liu, Jiangwen Wang, Shuai Liu, Bing Liu, Jianjie Xu, Zhaoyang Tong   +9 more
semanticscholar   +1 more source

Differential toxicity of abrin in human cell lines of different organ origin.

Toxicology in Vitro, 2021
Abrus precatorius is a highly toxic seed containing the poison abrin. Similar in properties to ricin, this toxin binds to ribosomes causing cessation of protein synthesis and cell death. With an estimated human lethal dose of 0.1-1 μg/kg, it has been the
N. Saxena, Pooja Phatak, V. Chauhan
semanticscholar   +1 more source

Effect of Moderate Thermal Stress on the Biological Efficacy of Plant Toxin Abrin in Mice

Journal of Current Toxicology and Venomics
Abrin is a well-known plant protein toxin with very high toxicity. It is a heterodimeric protein purified from seeds of the Abrus precatorius plant. Abrin is generally classified under the family of type II RIP.
Varsha Rani, Poorna Shri, D. P. Nagar, A. Bhaskar   +3 more
semanticscholar   +1 more source

Characterization Of Medicinally Important Plant Protein Abrin Through In-Silico Analysis

Physical Education, Health and Social Sciences
Abris precatorius is of great significance in medicine as it is a great source of variety of therapeutic compounds including abrin protein. Abrin exhibits anticancer and antimicrobial potential. However, its use is limited due to its toxicity.
R. Zaheer, M. Khurshid, Riffat Iqbal, Amna Saeed, Fatima Muccee   +4 more
semanticscholar   +1 more source

The history of ricin, abrin and related toxins

Toxicon, 2004
Ricin, abrin and related plant toxins have played interesting and important roles in the history of clinical medicine and biomedical research. The use of these proteins in medical treatment since ancient times is reviewed. Later the proteins played important roles in the early days of immunological research and some of the fundamental principles of ...
Sjur Olsnes
exaly   +3 more sources

Ricin and abrin

Medicine, 2007
Ricin is a type 2 ribosome-inactivating protein derived from the beans of the castor oil plant, Ricinus communis. It exerts toxicity by inhibiting protein synthesis. Many of the features seen in poisoning can be explained by ricin-induced endothelial cell damage, which leads to fluid and protein leakage and tissue oedema, causing so-called ‘vascular ...
openaire   +1 more source

Crystal Structure of Abrin-a at 2.14 Å

Journal of Molecular Biology, 1995
The crystal structure of abrin-a, a type II ribosome-inactivating protein from the seeds of Abrus precatorius, has been determined from a novel crystalline form by the molecular replacement method using the coordinates of ricin. The structure has been refined at 2.14 A to a R-factor of 18.9%.
T H, Tahirov, T H, Lu, Y C, Liaw, Y L, Chen, J Y, Lin   +4 more
openaire   +2 more sources

Evaluation of an Electrochemiluminescence Assay for the Rapid Detection of Abrin Toxin

Health Security, 2021
In this article, we detail a comprehensive laboratory evaluation of an immunoassay for the rapid detection of abrin using the Meso Scale Diagnostics Sector PR2 Model 1800.
C. Pillai, Gowri Manickam, Nagarajan Thirunavukkarasu, S. Pillai, S. Morse, J. R. Avila, David R. Hodge, Kevin Anderson, S. Sharma   +8 more
semanticscholar   +1 more source

Crystal structure of abrine

Journal of Crystallographic and Spectroscopic Research, 1993
The crystal structure of abrine (N-methyl L-tryptophan, (C12H14N2O2) was determined by X-ray diffraction. Space groupP212121,a=5.372(1),b=8.595(1) andc=24.082(2)A,Z=4,D m=1.30(4) gcm−3,D x=1.304 gcm−3,R=0.039 andwR=0.042. The conformational parameters for this structure following the IUPAC nomenclature areφ=67.7(5)°, ϰ1=−175(4)°, K21=105.2(7)° and χ22=−
J. Seetharaman, S. S. Rajan, R. Srinivasan   +2 more
openaire   +1 more source

Gaps in forensic toxicological analysis: The veiled abrin.

Toxicon
Abrus precatorius is an herbaceous, flowering plant that is widely distributed in tropical and subtropical regions. Its toxic component, known as abrin, is classified as one of the potentially significant biological warfare agents and bioterrorism tools ...
Yinyu Chen, Jiaqi Liu, Tao Song, Xing Zou, Leilei Li, Qianyun Nie, Peng Zhang   +6 more
semanticscholar   +1 more source