Results 11 to 20 of about 235,032 (267)

Effect of routine vs on-demand nebulization of acetylcysteine with salbutamol on accumulation of airway secretions in endotracheal tubes: substudy of a randomized clinical trial

Intensive Care Medicine Experimental, 2020
Background Accumulated airway secretions in the endotracheal tube increase work of breathing and may favor airway colonization eventually leading to pneumonia.
Sophia van der Hoeven, Lorenzo Ball, Federico Constantino, David M. van Meenen, Paolo Pelosi, Ludo F. Beenen, Marcus J. Schultz, Frederique Paulus, for the NEBULAE-investigators   +8 more
doaj   +1 more source

HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis

Frontiers in Immunology, 2021
Our previous work identified human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1) as a putative driver of LPS-induced NF-κB signaling in humans in vivo.
Hisatake Matsumoto, Brendon P. Scicluna, Brendon P. Scicluna, Kin Ki Jim, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gürkan, Erik Malmström, Mariska T. Meijer, Joe M. Butler, Hina N. Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J. Schultz, Marcus J. Schultz, Marcus J. Schultz, Diederik van de Beek, Alex F. de Vos, Cornelis van ‘t Veer, Tom van der Poll, Tom van der Poll   +21 more
doaj   +1 more source

Role of Myeloid Tet Methylcytosine Dioxygenase 2 in Pulmonary and Peritoneal Inflammation Induced by Lipopolysaccharide and Peritonitis Induced by Escherichia coli

Cells, 2021
Tet methylcytosine dioxygenase 2 (Tet2) mediates demethylation of DNA. We here sought to determine the expression and function of Tet2 in macrophages upon exposure to lipopolysaccharide (LPS), and in the host response to LPS induced lung and peritoneal ...
Wanhai Qin, Xanthe Brands, Hisatake Matsumoto, Joe M. Butler, Cornelis van’t Veer, Alex F. de Vos, Joris J. T. H. Roelofs, Brendon P. Scicluna, Tom van der Poll   +8 more
doaj   +1 more source

Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia

Annals of Intensive Care, 2021
Background A delay in admission to the intensive care unit (ICU) of patients with community-acquired pneumonia (CAP) has been associated with an increased mortality.
Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Olaf L. Cremer, Marcus J. Schultz, Marc M. J. Bonten, Brendon P. Scicluna, Tom van der Poll, the MARS consortium   +8 more
doaj   +1 more source

Staphylococcal Scalded Skin Syndrome in Neonates: Case Series and Overview of Outbreaks

Antibiotics, 2022
Skin and soft tissue infections caused by Staphylococcus aureus (S. aureus) cover a wide spectrum of diseases in neonates, including staphylococcal scalded skin syndrome (SSSS).
Charlotte M. Nusman, Charlotte Blokhuis, Dasja Pajkrt, Douwe H. Visser   +3 more
doaj   +1 more source

Inflammatory arthritis complicating galactosialidosis: a case report

BMC Rheumatology, 2021
Background Galactosialidosis (GS) is a rare inherited lysosomal storage disorder (LSD) which is characterized by a defect in the lysosomal glycoprotein catabolism.
F. Verkuil, A. M. Bosch, P. A. A. Struijs, R. Hemke, J. M. van den Berg   +4 more
doaj   +1 more source

Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model

Intensive Care Medicine Experimental, 2020
Introduction In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction of the microcirculation and ...
Mathijs R. Wirtz, Daan P. van den Brink, Joris J. T. H. Roelofs, J. Carel Goslings, Nicole P. Juffermans   +4 more
doaj   +1 more source

Induction of Acute or Disseminating Bacterial Pneumonia in Mice and Sampling of Infected Organs for Studying the Host Response to Bacterial Pneumonia

Bio-Protocol, 2022
Experimental pneumonia models are important tools to study the pathophysiology of lung inflammation caused by microbial infections and the efficacy of (novel) drugs.
Wanhai Qin, Zhe Liu, Tom van der Poll, Alex F. de Vos   +3 more
doaj   +1 more source

Psychopathological and Neurobiological Overlap Between Anorexia Nervosa and Self-Injurious Behavior: A Narrative Review and Conceptual Hypotheses

Frontiers in Psychiatry, 2022
Empirical evidence and clinical observations suggest a strong -yet under acknowledged-link between anorexia nervosa (AN) and non-suicidal self-injurious behavior (NSSI).
Marloes Oudijn, Jara Linders, Roel Mocking, Anja Lok, Annemarie van Elburg, D. Denys   +5 more
doaj   +1 more source

Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae

Respiratory Research, 2022
Background Liver kinase B1 (Lkb1, gene name Stk11) functions as a tumor suppressor in cancer. Myeloid cell Lkb1 potentiates lung inflammation induced by the Gram-negative bacterial cell wall component lipopolysaccharide and in host defense during Gram ...
Liza Pereverzeva, Natasja A. Otto, Joris J. T. H. Roelofs, Alex F. de Vos, Tom van der Poll   +4 more
doaj   +1 more source