Results 31 to 40 of about 253,180 (311)

DNA Methyltransferase 3b in Myeloid Cells Does Not Affect the Acute Immune Response in the Airways during Pseudomonas Pneumonia

Cells, 2022
DNA methyltransferase 3b (Dnmt3b) has been suggested to play a role in the host immune response during bacterial infection. Neutrophils and other myeloid cells are crucial for lung defense against Pseudomonas (P.) aeruginosa infection.
Wanhai Qin, Xanthe Brands, Cornelis van’t Veer, Alex F. de Vos, Brendon P. Scicluna, Tom van der Poll   +5 more
doaj   +1 more source

Ultrasound-guided lymph node biopsy sampling to study the immunopathogenesis of rheumatoid arthritis: a well-tolerated valuable research tool

Arthritis Research & Therapy, 2022
Background Analyses of lymphoid organs are required to further elucidate the pathogenesis of inflammatory diseases like rheumatoid arthritis (RA). Yet, invasive tissue collection methods are scarcely applied, because they are often considered burdensome,
Renée H. Fiechter, Janne W. Bolt, Marleen G. H. van de Sande, Caroline J. Aalbers, Robert B. M. Landewé, Mario Maas, Sander W. Tas, Lisa G. M. van Baarsen   +7 more
doaj   +1 more source

A natural history study of paediatric non-alcoholic fatty liver disease over 10 years

JHEP Reports, 2023
Background & Aims: The long-term outcome of paediatric non-alcoholic fatty liver disease (NAFLD) has not been well established. Between 2008 and 2012, an unselected cohort of 133 children with severe obesity was screened for NAFLD.
Laura Draijer, Maaike Voorhoeve, Marian Troelstra, Adriaan Holleboom, Ulrich Beuers, Meeike Kusters, Aart Nederveen, Marc Benninga, Bart Koot   +8 more
doaj   +1 more source

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing

Molecules, 2019
Sustained pacemaker function is a challenge in biological pacemaker engineering. Human cardiomyocyte progenitor cells (CMPCs) have exhibited extended survival in the heart after transplantation.
Anna M. D. Végh, A. Dénise den Haan, Lucía Cócera Ortega, Arie O. Verkerk, Joost P. G. Sluijter, Diane Bakker, Shirley van Amersfoorth, Toon A. B. van Veen, Mischa Klerk, Jurgen Seppen, Jacques M. T. de Bakker, Vincent M. Christoffels, Dirk Geerts, Marie José T. H. Goumans, Hanno L. Tan, Gerard J. J. Boink   +15 more
doaj   +1 more source

Ex vivo Validation of Noninvasive Epicardial and Endocardial Repolarization Mapping

Frontiers in Physiology, 2021
Background: The detection and localization of electrophysiological substrates currently involve invasive cardiac mapping. Electrocardiographic imaging (ECGI) using the equivalent dipole layer (EDL) method allows the noninvasive estimation of endocardial ...
Jeanne G. van der Waal, Veronique M. F. Meijborg, Charly N. W. Belterman, Geert J. Streekstra, Thom F. Oostendorp, Ruben Coronel, Ruben Coronel   +6 more
doaj   +1 more source

Knowledge Sharing in Academic Medical Centers [PDF]

, 2012
In light of substantial government subsidies, upcoming demographic shifts, new technologies, and financial downturns, higher education (HE) must adopt new approaches for knowledge creation and knowledge sharing to foster economic development.
Gladys L. Fernandez, Elisabeth E. Bennett, Rebecca D. Blanchard   +2 more
core   +1 more source

Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3

Frontiers in Cellular and Infection Microbiology, 2021
Human parechovirus (PeV-A), one of the species within the Picornaviridae family, is known to cause disease in humans. The most commonly detected genotypes are PeV-A1, associated with mild gastrointestinal disease in young children, and PeV-A3, linked to ...
Inés García-Rodríguez, Inés García-Rodríguez, Hetty van Eijk, Gerrit Koen, Dasja Pajkrt, Dasja Pajkrt, Adithya Sridhar, Adithya Sridhar, Katja C. Wolthers   +8 more
doaj   +1 more source

Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice

Frontiers in Immunology, 2021
Tenascin C (TNC) is an extracellular matrix glycoprotein that recently emerged as an immunomodulator. TNC-deficient (TNC−/−) mice were reported to have a reduced inflammatory response upon systemic administration of lipopolysaccharide, the toxic ...
Mariska T. Meijer, Mariska T. Meijer, Alex F. de Vos, Alex F. de Vos, Brendon P. Scicluna, Brendon P. Scicluna, Brendon P. Scicluna, Joris J. Roelofs, Chérine Abou Fayçal, Gertraud Orend, Fabrice Uhel, Fabrice Uhel, Tom van der Poll, Tom van der Poll, Tom van der Poll   +14 more
doaj   +1 more source

In Silico Prediction and Selection of Target Sequences in the SARS-CoV-2 RNA Genome for an Antiviral Attack

Viruses, 2022
The SARS-CoV-2 pandemic has urged the development of protective vaccines and the search for specific antiviral drugs. The modern molecular biology tools provides alternative methods, such as CRISPR-Cas and RNA interference, that can be adapted as ...
Mouraya Hussein, Zaria Andrade dos Ramos, Ben Berkhout, Elena Herrera-Carrillo   +3 more
doaj   +1 more source

The Academic Medical Center of the Future

Academic Medicine, 2000
The integrative sciences, which are of great practical and conceptual interest, investigate complex systems (cells, multicellular organisms, families, institutions, communities, nations, etc.) at the higher levels of organization. Academic medical centers are intrinsically integrative because of their mission and thus are likely places for integrative ...
J, Engelberg, P P, Bosomworth
openaire   +3 more sources