Results 31 to 40 of about 238,605 (266)

Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth During Klebsiella pneumoniae-Evoked Pneumosepsis in Mice

Frontiers in Immunology, 2021
Tenascin C (TNC) is an extracellular matrix glycoprotein that recently emerged as an immunomodulator. TNC-deficient (TNC−/−) mice were reported to have a reduced inflammatory response upon systemic administration of lipopolysaccharide, the toxic ...
Mariska T. Meijer, Mariska T. Meijer, Alex F. de Vos, Alex F. de Vos, Brendon P. Scicluna, Brendon P. Scicluna, Brendon P. Scicluna, Joris J. Roelofs, Chérine Abou Fayçal, Gertraud Orend, Fabrice Uhel, Fabrice Uhel, Tom van der Poll, Tom van der Poll, Tom van der Poll   +14 more
doaj   +1 more source

In Silico Prediction and Selection of Target Sequences in the SARS-CoV-2 RNA Genome for an Antiviral Attack

Viruses, 2022
The SARS-CoV-2 pandemic has urged the development of protective vaccines and the search for specific antiviral drugs. The modern molecular biology tools provides alternative methods, such as CRISPR-Cas and RNA interference, that can be adapted as ...
Mouraya Hussein, Zaria Andrade dos Ramos, Ben Berkhout, Elena Herrera-Carrillo   +3 more
doaj   +1 more source

The Academic Medical Center of the Future

Academic Medicine, 2000
The integrative sciences, which are of great practical and conceptual interest, investigate complex systems (cells, multicellular organisms, families, institutions, communities, nations, etc.) at the higher levels of organization. Academic medical centers are intrinsically integrative because of their mission and thus are likely places for integrative ...
J, Engelberg, P P, Bosomworth
openaire   +3 more sources

Sexual Development in Perinatally HIV-Infected Young People: A Systematic Review and Explorative Study

Sexual Medicine, 2022
: Background: Similar to other young people with a chronic health condition, perinatally HIV-infected (PHIV) adolescents may have an impacted sexual development.
A.M. ter Haar, MSc, A. Fieten, BSc, M. Van den Hof, MD, PhD, A. Malekzadeh, E.T.M. Laan, PhD, K.J. Oostrom, PhD, D. Pajkrt, Prof, MD, PhD   +6 more
doaj   +1 more source

Registries for orphan drugs: generating evidence or marketing tools?

Orphanet Journal of Rare Diseases, 2020
Independent disease registries for pre-and post-approval of novel treatments for rare diseases are increasingly important for healthcare professionals, patients, regulators and the pharmaceutical industry. Current registries for rare diseases to evaluate
Carla E. M. Hollak, Sandra Sirrs, Sibren van den Berg, Vincent van der Wel, Mirjam Langeveld, Hanka Dekker, Robin Lachmann, Saco J. de Visser   +7 more
doaj   +1 more source

mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo

Frontiers in Immunology, 2020
Introduction: Spondyloarthritis (SpA) is characterized by inflammation, articular bone erosions and pathologic new bone formation. Targeting TNFα or IL-17A with current available therapies reduces inflammation in SpA, however, treatment of the bone ...
Sijia Chen, Sijia Chen, Sijia Chen, Melissa N. van Tok, Melissa N. van Tok, Véronique L. Knaup, Lianne Kraal, Lianne Kraal, Désiree Pots, Désiree Pots, Lina Bartels, Ellen M. Gravallese, Joel D. Taurog, Marleen van de Sande, Marleen van de Sande, Leonie M. van Duivenvoorde, Leonie M. van Duivenvoorde, Dominique L. Baeten, Dominique L. Baeten, Dominique L. Baeten   +19 more
doaj   +1 more source

Pediatric Oncology Nursing Competencies in Latin America and the Caribbean: A Scoping Review to Inform Practice, Education, and Research

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Nurses are central to cancer care for children and adolescents, yet no comprehensive synthesis has defined essential core competencies for pediatric oncology nursing (PON) practice internationally, particularly in Latin America and the Caribbean (LAC).
Luís Carlos Lopes‐Júnior, Edmara Bazoni Soares Maia, Soad Fuentes‐Alabí, Courtney E. Sullivan, Monnie Abraham, Mauricio Maza, Liliana Vásquez Ponce, Regina Aparecida Garcia Lima   +7 more
wiley   +1 more source

Biostatistical resources in an academic medical center [PDF]

Journal of Thoracic Disease, 2018
Biomedical research published in peer-reviewed medical literature is necessary for promoting understanding, addressing novel clinical problems, and educating professionals on new surgical techniques and approaches.
Matthew S, Thiese, Andria, Thatcher, Melissa, Cheng   +2 more
openaire   +2 more sources

Pulmonary Dysfunction Is Associated With Sleep Study Abnormalities in Children With Sickle Cell Disease: A Multicenter Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Pulmonary dysfunction and sleep abnormalities are common in children with sickle cell disease (SCD) and are associated with worse clinical outcomes. Whether spirometry abnormalities are associated with polysomnography (PSG) findings remains unclear.
Ammar Saadoon Alishlash, Anis Rabbani Nourani, A. K. M. Fazlur Rahman, Dima Ezmigna, Tarig Ali‐Dinar   +4 more
wiley   +1 more source

Ecological momentary assessment versus retrospective assessment for measuring change in health-related quality of life following cardiac intervention

Journal of Patient-Reported Outcomes, 2020
Background Measuring change in health-related quality-of-life (HRQoL) is important to assess the impact of disease and/or treatment. Ecological momentary assessment (EMA) comprises the repeated assessment of momentary HRQoL in the natural environment and
Tom H. Oreel, Philippe Delespaul, Iris D. Hartog, José P. S. Henriques, Justine E. Netjes, Alexander B. A. Vonk, Jorrit Lemkes, Michael Scherer-Rath, Hanneke W. M. van Laarhoven, Mirjam A. G. Sprangers, Pythia T. Nieuwkerk   +10 more
doaj   +1 more source