Results 11 to 20 of about 253,180 (311)

Reengineering academic medical centers [PDF]

Academic Medicine, 1996
Academic medicine is entering an era of profound, unsettling change resulting not simply from the drastic transformation of the health care marketplace but more fundamentally from the chronic, growing gap between academic medicine's seemingly insatiable demand for total resources and the supply of resources that society is willing to provide.
Korn, David
openaire   +4 more sources

Academic Medical Centers and Conflicts of Interest [PDF]

JAMA, 2006
The author suggests a combination of educational outreach, clinical audits, mailed feedback of prescribing data, interactive peer group meetings, problem-based learning, and dissemination of prescribing guidelines to improve evidence-based general practitioner prescribing.
Smelser, Neil, Cohen, Jordan, Angell, Marcia, Kimball, Harry, Brennan, Troyen A., Blumenthal, David, Rothman, David J., Naughton, James, Goldman, JanLori, Kassirer, Jerome P.   +9 more
core   +8 more sources

Neural effects of deep brain stimulation on reward and loss anticipation and food viewing in anorexia nervosa: a pilot study

Journal of Eating Disorders, 2023
Background Anorexia nervosa (AN) is a severe and life-threatening psychiatric disorder. Initial studies on deep brain stimulation (DBS) in severe, treatment-refractory AN have shown clinical effects.
M. S. Oudijn, J. T. W. Linders, A. Lok, P. R. Schuurman, P. van den Munckhof, A. A. van Elburg, G. A. van Wingen, R. J. T. Mocking, D. Denys   +8 more
doaj   +1 more source

The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection

Frontiers in Immunology, 2021
Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic changes play a key role in the immune response to bacteria, among which DNA modifications that include methylation have received much attention in recent years.
Wanhai Qin, Brendon P. Scicluna, Brendon P. Scicluna, Tom van der Poll, Tom van der Poll   +4 more
doaj   +1 more source

Effect of routine vs on-demand nebulization of acetylcysteine with salbutamol on accumulation of airway secretions in endotracheal tubes: substudy of a randomized clinical trial

Intensive Care Medicine Experimental, 2020
Background Accumulated airway secretions in the endotracheal tube increase work of breathing and may favor airway colonization eventually leading to pneumonia.
Sophia van der Hoeven, Lorenzo Ball, Federico Constantino, David M. van Meenen, Paolo Pelosi, Ludo F. Beenen, Marcus J. Schultz, Frederique Paulus, for the NEBULAE-investigators   +8 more
doaj   +1 more source

HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis

Frontiers in Immunology, 2021
Our previous work identified human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1) as a putative driver of LPS-induced NF-κB signaling in humans in vivo.
Hisatake Matsumoto, Brendon P. Scicluna, Brendon P. Scicluna, Kin Ki Jim, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gürkan, Erik Malmström, Mariska T. Meijer, Joe M. Butler, Hina N. Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J. Schultz, Marcus J. Schultz, Marcus J. Schultz, Diederik van de Beek, Alex F. de Vos, Cornelis van ‘t Veer, Tom van der Poll, Tom van der Poll   +21 more
doaj   +1 more source

Role of Myeloid Tet Methylcytosine Dioxygenase 2 in Pulmonary and Peritoneal Inflammation Induced by Lipopolysaccharide and Peritonitis Induced by Escherichia coli

Cells, 2021
Tet methylcytosine dioxygenase 2 (Tet2) mediates demethylation of DNA. We here sought to determine the expression and function of Tet2 in macrophages upon exposure to lipopolysaccharide (LPS), and in the host response to LPS induced lung and peritoneal ...
Wanhai Qin, Xanthe Brands, Hisatake Matsumoto, Joe M. Butler, Cornelis van’t Veer, Alex F. de Vos, Joris J. T. H. Roelofs, Brendon P. Scicluna, Tom van der Poll   +8 more
doaj   +1 more source

A Grounded Theory of Decision Making and Cross-Subsidization of Academic Science at Academic Medical Centers [PDF]

, 2022
Academic medical centers employ a cross-subsidization model that draws from patient care revenue margins to alleviate predicted shortfalls in external funding for academic science.
Delaney, Susan Kathleen.
core   +2 more sources

Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia

Annals of Intensive Care, 2021
Background A delay in admission to the intensive care unit (ICU) of patients with community-acquired pneumonia (CAP) has been associated with an increased mortality.
Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Olaf L. Cremer, Marcus J. Schultz, Marc M. J. Bonten, Brendon P. Scicluna, Tom van der Poll, the MARS consortium   +8 more
doaj   +1 more source

Inflammatory arthritis complicating galactosialidosis: a case report

BMC Rheumatology, 2021
Background Galactosialidosis (GS) is a rare inherited lysosomal storage disorder (LSD) which is characterized by a defect in the lysosomal glycoprotein catabolism.
F. Verkuil, A. M. Bosch, P. A. A. Struijs, R. Hemke, J. M. van den Berg   +4 more
doaj   +1 more source