Results 21 to 30 of about 238,605 (266)

Induction of Acute or Disseminating Bacterial Pneumonia in Mice and Sampling of Infected Organs for Studying the Host Response to Bacterial Pneumonia

Bio-Protocol, 2022
Experimental pneumonia models are important tools to study the pathophysiology of lung inflammation caused by microbial infections and the efficacy of (novel) drugs.
Wanhai Qin, Zhe Liu, Tom van der Poll, Alex F. de Vos   +3 more
doaj   +1 more source

Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae

Respiratory Research, 2022
Background Liver kinase B1 (Lkb1, gene name Stk11) functions as a tumor suppressor in cancer. Myeloid cell Lkb1 potentiates lung inflammation induced by the Gram-negative bacterial cell wall component lipopolysaccharide and in host defense during Gram ...
Liza Pereverzeva, Natasja A. Otto, Joris J. T. H. Roelofs, Alex F. de Vos, Tom van der Poll   +4 more
doaj   +1 more source

Academic Medical Centers and Federally Qualified Health Centers: Collaboration for the Care of Underserved Communities. [PDF]

J Prim Care Community Health
Conway SJ, Murphy J, Efron JE.
europepmc   +2 more sources

Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Frontiers in Immunology, 2021
Bruton’s tyrosine kinase (Btk) is a cytoplasmic kinase expressed in B cells and myeloid cells. It is essential for B cell development and natural antibody-mediated host defense against bacteria in humans and mice, but little is known about the role of ...
Alexander P. de Porto, Zhe Liu, Zhe Liu, Regina de Beer, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van ‘t Veer, Cornelis van ‘t Veer, Tom van der Poll, Tom van der Poll, Tom van der Poll, Alex F. de Vos, Alex F. de Vos   +16 more
doaj   +1 more source

DNA Methyltransferase 3b in Myeloid Cells Does Not Affect the Acute Immune Response in the Airways during Pseudomonas Pneumonia

Cells, 2022
DNA methyltransferase 3b (Dnmt3b) has been suggested to play a role in the host immune response during bacterial infection. Neutrophils and other myeloid cells are crucial for lung defense against Pseudomonas (P.) aeruginosa infection.
Wanhai Qin, Xanthe Brands, Cornelis van’t Veer, Alex F. de Vos, Brendon P. Scicluna, Tom van der Poll   +5 more
doaj   +1 more source

Ultrasound-guided lymph node biopsy sampling to study the immunopathogenesis of rheumatoid arthritis: a well-tolerated valuable research tool

Arthritis Research & Therapy, 2022
Background Analyses of lymphoid organs are required to further elucidate the pathogenesis of inflammatory diseases like rheumatoid arthritis (RA). Yet, invasive tissue collection methods are scarcely applied, because they are often considered burdensome,
Renée H. Fiechter, Janne W. Bolt, Marleen G. H. van de Sande, Caroline J. Aalbers, Robert B. M. Landewé, Mario Maas, Sander W. Tas, Lisa G. M. van Baarsen   +7 more
doaj   +1 more source

A natural history study of paediatric non-alcoholic fatty liver disease over 10 years

JHEP Reports, 2023
Background & Aims: The long-term outcome of paediatric non-alcoholic fatty liver disease (NAFLD) has not been well established. Between 2008 and 2012, an unselected cohort of 133 children with severe obesity was screened for NAFLD.
Laura Draijer, Maaike Voorhoeve, Marian Troelstra, Adriaan Holleboom, Ulrich Beuers, Meeike Kusters, Aart Nederveen, Marc Benninga, Bart Koot   +8 more
doaj   +1 more source

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing

Molecules, 2019
Sustained pacemaker function is a challenge in biological pacemaker engineering. Human cardiomyocyte progenitor cells (CMPCs) have exhibited extended survival in the heart after transplantation.
Anna M. D. Végh, A. Dénise den Haan, Lucía Cócera Ortega, Arie O. Verkerk, Joost P. G. Sluijter, Diane Bakker, Shirley van Amersfoorth, Toon A. B. van Veen, Mischa Klerk, Jurgen Seppen, Jacques M. T. de Bakker, Vincent M. Christoffels, Dirk Geerts, Marie José T. H. Goumans, Hanno L. Tan, Gerard J. J. Boink   +15 more
doaj   +1 more source

Ex vivo Validation of Noninvasive Epicardial and Endocardial Repolarization Mapping

Frontiers in Physiology, 2021
Background: The detection and localization of electrophysiological substrates currently involve invasive cardiac mapping. Electrocardiographic imaging (ECGI) using the equivalent dipole layer (EDL) method allows the noninvasive estimation of endocardial ...
Jeanne G. van der Waal, Veronique M. F. Meijborg, Charly N. W. Belterman, Geert J. Streekstra, Thom F. Oostendorp, Ruben Coronel, Ruben Coronel   +6 more
doaj   +1 more source

Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3

Frontiers in Cellular and Infection Microbiology, 2021
Human parechovirus (PeV-A), one of the species within the Picornaviridae family, is known to cause disease in humans. The most commonly detected genotypes are PeV-A1, associated with mild gastrointestinal disease in young children, and PeV-A3, linked to ...
Inés García-Rodríguez, Inés García-Rodríguez, Hetty van Eijk, Gerrit Koen, Dasja Pajkrt, Dasja Pajkrt, Adithya Sridhar, Adithya Sridhar, Katja C. Wolthers   +8 more
doaj   +1 more source