Results 21 to 30 of about 838,813 (358)

Effect of routine vs on-demand nebulization of acetylcysteine with salbutamol on accumulation of airway secretions in endotracheal tubes: substudy of a randomized clinical trial

Intensive Care Medicine Experimental, 2020
Background Accumulated airway secretions in the endotracheal tube increase work of breathing and may favor airway colonization eventually leading to pneumonia.
Sophia van der Hoeven, Lorenzo Ball, Federico Constantino, David M. van Meenen, Paolo Pelosi, Ludo F. Beenen, Marcus J. Schultz, Frederique Paulus, for the NEBULAE-investigators   +8 more
doaj   +1 more source

HIVEP1 Is a Negative Regulator of NF-κB That Inhibits Systemic Inflammation in Sepsis

Frontiers in Immunology, 2021
Our previous work identified human immunodeficiency virus type I enhancer binding protein 1 (HIVEP1) as a putative driver of LPS-induced NF-κB signaling in humans in vivo.
Hisatake Matsumoto, Brendon P. Scicluna, Brendon P. Scicluna, Kin Ki Jim, Kin Ki Jim, Fahimeh Falahi, Wanhai Qin, Berke Gürkan, Erik Malmström, Mariska T. Meijer, Joe M. Butler, Hina N. Khan, Tsuyoshi Takagi, Shunsuke Ishii, Marcus J. Schultz, Marcus J. Schultz, Marcus J. Schultz, Diederik van de Beek, Alex F. de Vos, Cornelis van ‘t Veer, Tom van der Poll, Tom van der Poll   +21 more
doaj   +1 more source

Role of Myeloid Tet Methylcytosine Dioxygenase 2 in Pulmonary and Peritoneal Inflammation Induced by Lipopolysaccharide and Peritonitis Induced by Escherichia coli

Cells, 2021
Tet methylcytosine dioxygenase 2 (Tet2) mediates demethylation of DNA. We here sought to determine the expression and function of Tet2 in macrophages upon exposure to lipopolysaccharide (LPS), and in the host response to LPS induced lung and peritoneal ...
Wanhai Qin, Xanthe Brands, Hisatake Matsumoto, Joe M. Butler, Cornelis van’t Veer, Alex F. de Vos, Joris J. T. H. Roelofs, Brendon P. Scicluna, Tom van der Poll   +8 more
doaj   +1 more source

Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia

Annals of Intensive Care, 2021
Background A delay in admission to the intensive care unit (ICU) of patients with community-acquired pneumonia (CAP) has been associated with an increased mortality.
Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Olaf L. Cremer, Marcus J. Schultz, Marc M. J. Bonten, Brendon P. Scicluna, Tom van der Poll, the MARS consortium   +8 more
doaj   +1 more source

Staphylococcal Scalded Skin Syndrome in Neonates: Case Series and Overview of Outbreaks

Antibiotics, 2022
Skin and soft tissue infections caused by Staphylococcus aureus (S. aureus) cover a wide spectrum of diseases in neonates, including staphylococcal scalded skin syndrome (SSSS).
Charlotte M. Nusman, Charlotte Blokhuis, Dasja Pajkrt, Douwe H. Visser   +3 more
doaj   +1 more source

Overcoming barriers to the adoption and implementation of predictive modeling and machine learning in clinical care: what can we learn from US academic medical centers?

JAMIA Open, 2020
There is little known about how academic medical centers (AMCs) in the US develop, implement, and maintain predictive modeling and machine learning (PM and ML) models.
Joshua Watson, C. Hutyra, Shayna M. Clancy, Anisha Chandiramani, A. Bedoya, K. Ilangovan, Nancy Nderitu, E. Poon   +7 more
semanticscholar   +1 more source

COVID-19: Financial Stress Test for Academic Medical Centers

Academic medicine : journal of the Association of American Medical Colleges, 2020
The coronavirus pandemic (COVID-19) is having profound effects on the lives and well-being of the world’s population. All levels of the nation’s public health and health care delivery systems are rapidly adjusting to secure the health infrastructure to ...
C. Colenda, W. Applegate, B. Reifler, D. Blazer   +3 more
semanticscholar   +1 more source

Inflammatory arthritis complicating galactosialidosis: a case report

BMC Rheumatology, 2021
Background Galactosialidosis (GS) is a rare inherited lysosomal storage disorder (LSD) which is characterized by a defect in the lysosomal glycoprotein catabolism.
F. Verkuil, A. M. Bosch, P. A. A. Struijs, R. Hemke, J. M. van den Berg   +4 more
doaj   +1 more source

Meeting the Patient Care, Education, and Research Missions: Academic Medical Centers Must Comprehensively Address Sexual and Gender Minority Health.

Academic medicine : journal of the Association of American Medical Colleges, 2020
While sociopolitical advances have improved the rights of sexual and gender minorities (i.e., lesbian, gay, bisexual, transgender, queer [LGBTQ+] persons), they continue to face a health system that discriminates against them and does not provide ...
Carl G. Streed, M. Lunn, J. Siegel, J. Obedin-Maliver   +3 more
semanticscholar   +1 more source

Creating Real Change at Academic Medical Centers - How Social Movements Can Be Timely Catalysts.

New England Journal of Medicine, 2020
Creating Real Change at Academic Medical Centers Capitalizing on the urgency generated by the Black Lives Matter movement, residents and faculty at an academic health care institution take steps to...
M. Morse, J. Loscalzo
semanticscholar   +1 more source