Results 21 to 30 of about 235,032 (267)

Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Frontiers in Immunology, 2021
Bruton’s tyrosine kinase (Btk) is a cytoplasmic kinase expressed in B cells and myeloid cells. It is essential for B cell development and natural antibody-mediated host defense against bacteria in humans and mice, but little is known about the role of ...
Alexander P. de Porto, Zhe Liu, Zhe Liu, Regina de Beer, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van ‘t Veer, Cornelis van ‘t Veer, Tom van der Poll, Tom van der Poll, Tom van der Poll, Alex F. de Vos, Alex F. de Vos   +16 more
doaj   +1 more source

Mentorship in an Academic Medical Center [PDF]

The American Journal of Medicine, 2013
Effective mentorship has been shown to be essential for faculty career success in a wide array of academic disciplines, including medicine (1–3).Faculty members who are engaged in effective mentoring relationships are more likely to remain at academic medical centers and advance in rank more rapidly (4–8).
Philip F, Binkley, Heather C, Brod
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DNA Methyltransferase 3b in Myeloid Cells Does Not Affect the Acute Immune Response in the Airways during Pseudomonas Pneumonia

Cells, 2022
DNA methyltransferase 3b (Dnmt3b) has been suggested to play a role in the host immune response during bacterial infection. Neutrophils and other myeloid cells are crucial for lung defense against Pseudomonas (P.) aeruginosa infection.
Wanhai Qin, Xanthe Brands, Cornelis van’t Veer, Alex F. de Vos, Brendon P. Scicluna, Tom van der Poll   +5 more
doaj   +1 more source

Ultrasound-guided lymph node biopsy sampling to study the immunopathogenesis of rheumatoid arthritis: a well-tolerated valuable research tool

Arthritis Research & Therapy, 2022
Background Analyses of lymphoid organs are required to further elucidate the pathogenesis of inflammatory diseases like rheumatoid arthritis (RA). Yet, invasive tissue collection methods are scarcely applied, because they are often considered burdensome,
Renée H. Fiechter, Janne W. Bolt, Marleen G. H. van de Sande, Caroline J. Aalbers, Robert B. M. Landewé, Mario Maas, Sander W. Tas, Lisa G. M. van Baarsen   +7 more
doaj   +1 more source

The Economics of Academic Medical Centers [PDF]

New England Journal of Medicine, 2014
Economists tend to examine support for graduate medical education in isolation rather than as part of the complex economics of academic medical centers, which have several interrelated missions. GME costs far exceed those partially covered by direct GME support.
Atul, Grover, Peter L, Slavin, Peters, Willson   +2 more
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A natural history study of paediatric non-alcoholic fatty liver disease over 10 years

JHEP Reports, 2023
Background & Aims: The long-term outcome of paediatric non-alcoholic fatty liver disease (NAFLD) has not been well established. Between 2008 and 2012, an unselected cohort of 133 children with severe obesity was screened for NAFLD.
Laura Draijer, Maaike Voorhoeve, Marian Troelstra, Adriaan Holleboom, Ulrich Beuers, Meeike Kusters, Aart Nederveen, Marc Benninga, Bart Koot   +8 more
doaj   +1 more source

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing

Molecules, 2019
Sustained pacemaker function is a challenge in biological pacemaker engineering. Human cardiomyocyte progenitor cells (CMPCs) have exhibited extended survival in the heart after transplantation.
Anna M. D. Végh, A. Dénise den Haan, Lucía Cócera Ortega, Arie O. Verkerk, Joost P. G. Sluijter, Diane Bakker, Shirley van Amersfoorth, Toon A. B. van Veen, Mischa Klerk, Jurgen Seppen, Jacques M. T. de Bakker, Vincent M. Christoffels, Dirk Geerts, Marie José T. H. Goumans, Hanno L. Tan, Gerard J. J. Boink   +15 more
doaj   +1 more source

Ex vivo Validation of Noninvasive Epicardial and Endocardial Repolarization Mapping

Frontiers in Physiology, 2021
Background: The detection and localization of electrophysiological substrates currently involve invasive cardiac mapping. Electrocardiographic imaging (ECGI) using the equivalent dipole layer (EDL) method allows the noninvasive estimation of endocardial ...
Jeanne G. van der Waal, Veronique M. F. Meijborg, Charly N. W. Belterman, Geert J. Streekstra, Thom F. Oostendorp, Ruben Coronel, Ruben Coronel   +6 more
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Parechovirus A Infection of the Intestinal Epithelium: Differences Between Genotypes A1 and A3

Frontiers in Cellular and Infection Microbiology, 2021
Human parechovirus (PeV-A), one of the species within the Picornaviridae family, is known to cause disease in humans. The most commonly detected genotypes are PeV-A1, associated with mild gastrointestinal disease in young children, and PeV-A3, linked to ...
Inés García-Rodríguez, Inés García-Rodríguez, Hetty van Eijk, Gerrit Koen, Dasja Pajkrt, Dasja Pajkrt, Adithya Sridhar, Adithya Sridhar, Katja C. Wolthers   +8 more
doaj   +1 more source

Reengineering academic medical centers

Academic Medicine, 1996
Academic medicine is entering an era of profound, unsettling change resulting not simply from the drastic transformation of the health care marketplace but more fundamentally from the chronic, growing gap between academic medicine's seemingly insatiable demand for total resources and the supply of resources that society is willing to provide.
openaire   +3 more sources