Results 31 to 40 of about 838,813 (358)

Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model

Intensive Care Medicine Experimental, 2020
Introduction In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction of the microcirculation and ...
Mathijs R. Wirtz, Daan P. van den Brink, Joris J. T. H. Roelofs, J. Carel Goslings, Nicole P. Juffermans   +4 more
doaj   +1 more source

Induction of Acute or Disseminating Bacterial Pneumonia in Mice and Sampling of Infected Organs for Studying the Host Response to Bacterial Pneumonia

Bio-Protocol, 2022
Experimental pneumonia models are important tools to study the pathophysiology of lung inflammation caused by microbial infections and the efficacy of (novel) drugs.
Wanhai Qin, Zhe Liu, Tom van der Poll, Alex F. de Vos   +3 more
doaj   +1 more source

The valorization of non-patent intellectual property in academic medical centers

Journal of Technology Transfer, 2020
Turning university research output into useful products such as drugs, devices and diagnostics requires skills, knowledge, and resources traditionally attributed to private industry.
K. Marr, Phillip Phan
semanticscholar   +1 more source

Psychopathological and Neurobiological Overlap Between Anorexia Nervosa and Self-Injurious Behavior: A Narrative Review and Conceptual Hypotheses

Frontiers in Psychiatry, 2022
Empirical evidence and clinical observations suggest a strong -yet under acknowledged-link between anorexia nervosa (AN) and non-suicidal self-injurious behavior (NSSI).
Marloes Oudijn, Jara Linders, Roel Mocking, Anja Lok, Annemarie van Elburg, D. Denys   +5 more
doaj   +1 more source

Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae

Respiratory Research, 2022
Background Liver kinase B1 (Lkb1, gene name Stk11) functions as a tumor suppressor in cancer. Myeloid cell Lkb1 potentiates lung inflammation induced by the Gram-negative bacterial cell wall component lipopolysaccharide and in host defense during Gram ...
Liza Pereverzeva, Natasja A. Otto, Joris J. T. H. Roelofs, Alex F. de Vos, Tom van der Poll   +4 more
doaj   +1 more source

Bruton’s Tyrosine Kinase-Mediated Signaling in Myeloid Cells Is Required for Protective Innate Immunity During Pneumococcal Pneumonia

Frontiers in Immunology, 2021
Bruton’s tyrosine kinase (Btk) is a cytoplasmic kinase expressed in B cells and myeloid cells. It is essential for B cell development and natural antibody-mediated host defense against bacteria in humans and mice, but little is known about the role of ...
Alexander P. de Porto, Zhe Liu, Zhe Liu, Regina de Beer, Regina de Beer, Sandrine Florquin, Joris J. T. H. Roelofs, Onno J. de Boer, Joke M. M. den Haan, Rudi W. Hendriks, Cornelis van ‘t Veer, Cornelis van ‘t Veer, Tom van der Poll, Tom van der Poll, Tom van der Poll, Alex F. de Vos, Alex F. de Vos   +16 more
doaj   +1 more source

Mentorship in an Academic Medical Center [PDF]

The American Journal of Medicine, 2013
Effective mentorship has been shown to be essential for faculty career success in a wide array of academic disciplines, including medicine (1–3).Faculty members who are engaged in effective mentoring relationships are more likely to remain at academic medical centers and advance in rank more rapidly (4–8).
Philip F, Binkley, Heather C, Brod
openaire   +2 more sources

Use of electronic health records to support a public health response to the COVID-19 pandemic in the United States: a perspective from 15 academic medical centers

J. Am. Medical Informatics Assoc., 2020
Our goal is to summarize the collective experience of 15 organizations in dealing with uncoordinated efforts that result in unnecessary delays in understanding, predicting, preparing for, containing, and mitigating the COVID-19 pandemic in the US ...
Subha Madhavan, L. Bastarache, Jeffrey S. Brown, A. Butte, D. Dorr, P. Embí, C. Friedman, Kevin B. Johnson, J. Moore, I. Kohane, Philip R. O. Payne, J. Tenenbaum, M. Weiner, A. Wilcox, L. Ohno-Machado   +14 more
semanticscholar   +1 more source

DNA Methyltransferase 3b in Myeloid Cells Does Not Affect the Acute Immune Response in the Airways during Pseudomonas Pneumonia

Cells, 2022
DNA methyltransferase 3b (Dnmt3b) has been suggested to play a role in the host immune response during bacterial infection. Neutrophils and other myeloid cells are crucial for lung defense against Pseudomonas (P.) aeruginosa infection.
Wanhai Qin, Xanthe Brands, Cornelis van’t Veer, Alex F. de Vos, Brendon P. Scicluna, Tom van der Poll   +5 more
doaj   +1 more source

Use of Facebook by Academic Medical Centers in Taiwan During the COVID-19 Pandemic: Observational Study

Journal of Medical Internet Research, 2020
Background The battle against COVID-19 remains ongoing, and social media has played an important role during the crisis for both communication and health promotion, particularly for health care organizations. Taiwan’s success during the COVID-19 outbreak
W. Chu, Gow-Jen Shieh, Shi-Liang Wu, W. Sheu   +3 more
semanticscholar   +1 more source