Results 41 to 50 of about 235,032 (267)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Spatial CT perfusion data helpful in automatically locating vessel occlusions for acute ischemic stroke patients

Frontiers in Neurology, 2023
IntroductionLocating a vessel occlusion is important for clinical decision support in stroke healthcare. The advent of endovascular thrombectomy beyond proximal large vessel occlusions spurs alternative approaches to locate vessel occlusions.
Daan Peerlings, Hugo W. A. M. de Jong, Edwin Bennink, Edwin Bennink, Jan W. Dankbaar, Birgitta K. Velthuis, Bart J. Emmer, Charles B. L. M. Majoie, Henk A. Marquering, Henk A. Marquering   +9 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Enrichment of type 1 innate lymphoid cells in the course of human atherosclerotic plaque development suggests contribution to atherogenesis

Frontiers in Immunology
IntroductionInnate lymphoid cells (ILCs) have been implicated in multiple pathologic conditions, including atherogenesis, as documented in experimental mice studies, however, their role in atherosclerosis in humans remains unexplored.MethodsHere, we ...
Kartika R. Pertiwi, Kartika R. Pertiwi, Marcel B. M. Teunissen, Gabrielle Krebbers, Martine C.M. Willems, Martine C.M. Willems, Laurens Huisman, Laurens Huisman, Cindy Poelen, Allard C. van der Wal, Onno J. de Boer   +10 more
doaj   +1 more source

Fatigue in children and adolescents perinatally infected with human immunodeficiency virus: an observational study

BMC Pediatrics, 2021
Background Fatigue is common among adults living with human immunodeficiency virus (HIV) as well as children with a chronic disease (CCD). Fatigue can have disastrous effects on health status, including health related quality of life (HRQOL).
A. M. ter Haar, M. M. Nap-van der Vlist, M. Van den Hof, S. L. Nijhof, R. R. L. van Litsenburg, K. J. Oostrom, D. Pajkrt   +6 more
doaj   +1 more source

Medical service plans in academic medical centers

Academic Medicine, 1978
Medical service plans are of major importance to academic medical centers and are becoming increasingly so each year as evidenced by growing dependence of medical schools on resulting funds. How these funds are generated and used varies among schools.
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Load distribution after unilateral condylar fracture with shortening of the ramus: a finite element model study

Head & Face Medicine, 2023
Objectives After a fracture of the condyle, the fractured ramus is often shortened, which causes premature dental contact on the fractured side and a contralateral open bite.
Loreine M. L. Helmer, Cornelis Klop, Frank Lobbezoo, Jan de Lange, Jan Harm Koolstra, Leander Dubois   +5 more
doaj   +1 more source

Current evidence on the adoption of indicator condition guided testing for HIV in western countries: A systematic review and meta-analysis

EClinicalMedicine, 2021
Background: Indicator condition (IC) guided testing for HIV is an effective way to identify undiagnosed people living with HIV, but studies suggest its implementation is lacking.
S.J. Bogers, S.H. Hulstein, M.F. Schim van der Loeff, G.J. de Bree, P. Reiss, J.E.A.M van Bergen, S.E. Geerlings   +6 more
doaj   +1 more source