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Desmosomal-Type Acantholysis—A New Histologic Pattern Related to Mutations of Genes for Desmosomal Proteins [PDF]
DermatopathologyDesmosomes are specialized cell–cell junctions that play a crucial role in maintaining the structural integrity of both cornifying and non-cornifying epithelium. Disruption of desmosomal cohesion in autoimmune, infectious, and other diseases is typically
Dieter Metze +4 more
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Caspase-activation powers anti-Desmoglein 3-induced acantholysis in human epidermis [PDF]
Cell Death DiscoveryPemphigus vulgaris (PV) is a life-threatening autoimmune blistering disease caused by circulating autoantibodies against desmoglein (Dsg) 1 and Dsg 3.
Morna F. Schmidt +10 more
doaj +3 more sources
Journal of Cutaneous Immunology and Allergy, 2019 Objectives Acantholysis is the main pathologic finding in pemphigus, and its location has been historically used to distinguish the major subtypes of pemphigus vulgaris (PV) and pemphigus foliaceus (PF).
Nazanin Rajai, Azita Nikoo, Ali Nili
exaly +2 more sources
Mechanisms of Acantholysis in Pemphigus: Mechanical or Inflammatory?
European Journal of Inflammation, 2006 Pemphigus is a rare autoimmune disease, involving the skin and mucous epithelia, characterized by flaccid blisters and erosions. Histologically, the basic abnormality in all forms of pemphigus is the separation of keratinocytes from one another, a ...
Giacomo Caldarola, Claudio Feliciani
exaly +2 more sources
Verruciform genital-associated xanthoma with acantholysis: Report of a rare case
JAAD Case Reports, 2020 Torsten Ehrig
exaly +3 more sources
Biology, 2022 Background: Pemphigus vulgaris (PV) is an IgG-mediated autoimmune disease characterised by epithelial cell–cell detachment (acantholysis) resulting in mucocutaneous blistering.
Sanna Huda +5 more
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Post-Pemphigus Acanthomata Presenting as an Isolated, Hyperkeratotic Plaque
Dermatopathology, 2023 Post-pemphigus acanthomas have been rarely discussed in the literature. A prior case series identified 47 cases of pemphigus vulgaris and 5 cases of pemphigus foliaceus, out of which 13 developed acanthomata as a part of the healing process. Additionally,
Rachita Pandya +4 more
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Spongiotic Pattern in Pemphigus: A Retrospective Observational Single-Center Study
Dermatopathology, 2022 Pemphigus is a chronic blistering disorder caused by autoantibodies that target desmosomal proteins in the epidermis. Acantholysis may be absent, and pemphigus may present only with spongiosis and vesiculation, thereby leading to a misdiagnosis of eczema.
Ivan Arni C. Preclaro, Yu-Hung Wu
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Innate immune activation as cofactor in pemphigus disease manifestation
Frontiers in Immunology, 2022 Molecular mechanisms underlying auto-antibody-induced acantholysis in pemphigus vulgaris are subject of current research to date. To decipher the discrepancy between ubiquitous antibody binding to the epidermal desmosomes, but discontinuous disease ...
Ramona A. Eichkorn +7 more
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Pemphigus vulgaris: A rare case of gingival involvement
Contemporary Clinical Dentistry, 2020 Pemphigus vulgaris (PV) is an autoimmune mucocutaneous disease characterized by epithelial blistering affecting the mucosal/cutaneous surfaces. This case report demonstrates the oral manifestations of PV in the uncommon locations such as the attached ...
Nisha Thakur +3 more
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