Results 61 to 70 of about 25,167 (195)

Acarbose impairs gut Bacteroides growth by targeting intracellular glucosidases

mBio
Acarbose is a type 2 diabetes medicine that prevents dietary starch breakdown into glucose by inhibiting host amylase and glucosidase enzymes. Numerous gut species in the Bacteroides genus enzymatically break down starch and change in relative abundance ...
Haley A. Brown, Adeline L. Morris, Nicholas A. Pudlo, Ashley E. Hopkins, Eric C. Martens, Jonathan L. Golob, Nicole M. Koropatkin   +6 more
doaj   +1 more source

Optimization of bioactive compounds extraction from Rosa canina L. pseudofruit through the action of two hydrolytic enzyme preparations

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKROUND The pseudo‐fruit of Rosa canina L. is a rich source of bioactive compounds with antioxidant, anti‐inflammatory, anti‐cancer, anti‐diabetic, anti‐aging, and antimicrobial activities. The aim of the present study is the optimization of a green process based on the action of two hydrolytic enzyme preparations, namely Pectinex® Ultra ...
Zafeiria Lemoni, Styliani Kalantzi, Theopisti Lymperopoulou, Andromachi Tzani, Georgios Stavropoulos, Anastasia Detsi, Diomi Mamma   +6 more
wiley   +1 more source

Relationship between the peroxidation of leukocytes index ratio and the improvement of postprandial metabolic stress by a functional food [PDF]

, 2015
For the first time, we investigated the relationship between postprandial dysmetabolism and the Peroxidation of Leukocytes Index Ratio (PLIR), a test that measures the resistance of leukocytes to exogenous oxidative stress and their functional capacity ...
Longhitano, Yaroslava, Manafikhi, Husseen, Palmery, Maura, Peluso, Ilaria, Reggi, Raffaella, Zanza, Christian   +5 more
core   +4 more sources

Potential of solid‐state microwaves in lab‐scale chemical‐process development

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The integration of a solid‐state microwave (MW) generator into a newly designed, versatile MW reactor ensures improved energy efficiency, precise process control and broader application potential. In its most particular feature, the device supports the modification of dielectric‐radiation orientation and can be operated under ...
Christian Cravotto, Clelia Aimone, Giorgio Capaldi, Giorgio Grillo, Giancarlo Cravotto   +4 more
wiley   +1 more source

Comparative functional genomics of the acarbose producers reveals potential targets for metabolic engineering

Synthetic and Systems Biotechnology, 2019
The α-glucosidase inhibitor acarbose is produced in large-scale by strains derived from Actinoplanes sp. SE50 and used widely for the treatment of type-2 diabetes. Compared with the wild-type SE50, a high-yield derivative Actinoplanes sp.
Huixin Xie, Qinqin Zhao, Xin Zhang, Qianjin Kang, Linquan Bai   +4 more
doaj   +1 more source

Structural Enzymology of Cellvibrio japonicus Agd31B Protein Reveals α-Transglucosylase Activity in Glycoside Hydrolase Family 31 [PDF]

, 2012
The metabolism of the storage polysaccharides glycogen and starch is of vital importance to organisms from all domains of life. In bacteria, utilization of these -glucans requires the concerted action of a variety of enzymes, including glycoside ...
Adams, Atsushi Izumi, Ball, Barends, Becker, Berezina, Boos, Burlingham, Cantarel, Cowtan, Davies, Davies, DeBoy, Dippel, Elbein, Emsley, Ernst, Gasteiger, Gibson, Gideon J. Davies, Glyn R. Hemsworth, Harry Brumer, Hazlewood, Hendlich, Humphry, Janecek, Johan Larsbrink, Jones, Jung, Kato, Kim, Kim, Kim, Larsbrink, Lee, Lee, Leemhuis, Leslie, Liebl, Lovering, Meissner, Mukai, Okuyama, Palmer, Perrakis, Przylas, Ren, Roach, Rossi, Roujeinikova, Roujeinikova, Schwartz, Seo, Sim, Sim, Sinnott, Stam, Stick, Sundqvist, Suzuki, Takaha, Takaha, Tan, Terada, Vagin, Vonrhein, Wang, Wilson, Winn, Withers, Yamamoto, Zhou   +71 more
core   +1 more source

Recycling of hazelnut waste: Antidiabetic properties of soy lecithin nanoparticles and their in vitro anti‐proliferative effects in tumor cell lines

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Hazelnuts and foods produced using hazelnuts are consumed with pleasure, but it is important to evaluate the waste generated during hazelnut processing and determine their usage methods. RESULTS This study was conducted to determine the changes in bioactive components, bioaccessibility and antidiabetic activity of nanoparticles ...
Mehmet Ali Temiz, Emine Okumus
wiley   +1 more source

Effect of Acarbose on High Carohydrate Diet Induced Liver Injury in Largemouth Bass (Micropterus salmoides)

Guangdong nongye kexue
【Objective】The study was conducted to investigate the effect of acarbose on high-carbohydrate dietinduced liver injury in largemouth bass and to detect similar functional therapeutic drugs in the initial screening.【Method】The largemouth bass (Micropterus
Yanhao CAO, Xiaolong BO, Hongli LIU, Xiaoli HUANG   +3 more
doaj   +1 more source

Exploration of the Phytochemical and Antidiabetic Properties of Teucrium polium: A Natural Asset for Type 2 Diabetes Management

ChemistryOpen, EarlyView.
Teucrium polium shows antidiabetic activity with its phytochemical composition and biological activities. The essential oil is rich in carvacrol, thymol, γ‐terpinene, and o‐cymene, while the aqueous and hydroethanolic extracts are characterized by poliumoside, verbascoside, isorhamnetin‐3‐O‐rutinoside, and apigenin‐7‐rutinoside. Antioxidant activity is
Hajar El Ouadni, Aziz Drioiche, Fadoua El Makhoukhi, Omkulthom Al kamaly, Hannou Zerkani, Smail Amalich, Imane Tagnaout, Mohamed Radi, Yahya Cherrah, Touriya Zair, Katim Alaoui   +10 more
wiley   +1 more source

The effects of acarbose therapy on reductions of myocardial infarction and all-cause death in T2DM during 10-year multifactorial interventions (The Beijing Community Diabetes Study 24)

Scientific Reports, 2021
To investigate the potential benefits of acarbose therapy on cardiovascular events (CVD) in Type 2 diabetes (T2DM) in an urban community over 10-year follow-up.
Xue-Lian Zhang, Shen-Yuan Yuan, Gang Wan, Ming-Xia Yuan, Guang-Ran Yang, Han-Jing Fu, Liang-Xiang Zhu, Jian-Dong Zhang, Yu-Ling Li, Da-yong Gao, Xue-Li Cui, Zi-ming Wang, Rong-Rong Xie, Ying-jun Chen   +13 more
doaj   +1 more source