Results 91 to 100 of about 3,485,354 (289)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Aging connection (Columbus, Ohio : Online)

, 2006
Monthly; Electronic coverage as of May 22, 2007: Mar. 2006-; Description based on Mar. 2006; title from Web page (viewed on May 22, 2007).; Harvested from the web on 5/22/07June 2006, Ohio Leads Nation in Senior Services Levy Revenue. Department of Aging
Ohio. Dept. of Aging
core  

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Does HIV accelerate the aging process? An assessment of clinical, ophthalmic and serum parameters in HIV-infected individuals in South Africa [PDF]

HIV-infected individuals are at increased risk of age-related non-AIDS morbidity and mortality compared with HIV-uninfected persons. It is speculated that HIV-infected individuals may not only be aging chronologically, but also undergoing accelerated ...
Pathai, S
core   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Association Between Estimated Glucose Disposal Rate and Biological Aging Among U.S. Adults: A Cross‐Sectional Study

Health Science Reports
Background and Aims Biomarkers of biological aging, including homeostatic dysregulation (HD), Klemera–Doubal method biological age (KDM‐BA), and phenotypic age (PA), provide multidimensional quantification of the aging process.
Mengjie Zhao, Jing Cao, Mengxuan Li, Jiwei Zhang, Wantong Zhang, Qiuyan Li   +5 more
doaj   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging

Microbiome
Background People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation.
Shalini Singh, Leila B. Giron, Maliha W. Shaikh, Shivanjali Shankaran, Phillip A. Engen, Zlata R. Bogin, Simona A. Bambi, Aaron R. Goldman, Joao L. L. C. Azevedo, Lorena Orgaz, Nuria de Pedro, Patricia González, Martin Giera, Aswin Verhoeven, Elena Sánchez-López, Ivona Pandrea, Toshitha Kannan, Ceylan E. Tanes, Kyle Bittinger, Alan L. Landay, Michael J. Corley, Ali Keshavarzian, Mohamed Abdel-Mohsen   +22 more
doaj   +1 more source

Gestational Diabetes Mellitus and Accelerated Biological Aging in Middle-Aged and Elderly Women

Diabetes Care
OBJECTIVE To evaluate the association between gestational diabetes mellitus (GDM) and accelerated biological aging in middle-aged and elderly women. RESEARCH DESIGN AND METHODS We included parous women with a baseline survey on history
Bin Wang, Ningjian Wang, Xin Yin, Yuhui Huang, Guoqi Yu, Jiaxi Yang, Yap Seng Chong, Yingli Lu, Michelle A. Williams, Frank B. Hu, Cuilin Zhang   +10 more
openaire   +2 more sources

Aging in a relativistic biological space-time

, 2017
Here we present a theoretical and mathematical perspective on the process of aging. We extend the concepts of physical space and time to an abstract, mathematically-defined space, which we associate with a concept of “biological space-time” in which ...
N. Carlesso, R. Rockne, G. Marcucci, V. Adhikarla, D. Maestrini, D. Abler, S. Armenian, Y-H. Kuo, S. Branciamore, P. Sahoo   +9 more
core   +1 more source