Results 111 to 120 of about 3,485,354 (289)

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

Association between biological aging and coronary heart disease: A secondary analysis of two observational studies

iScience
Summary: While aging is a well-established contributor to cardiovascular disease, the specific relation between biological aging—as assessed by PhenoAge and PhenoAge acceleration—and the risk of coronary heart disease (CHD) requires further evidence to ...
Shiying Lin, Minghuan Liu, Xinyue Lu, Yang Song, Huangyuan Li, Feng Hu, Lin Fan, Xiaoxu Xie, Shaowei Lin, Siying Wu   +9 more
doaj   +1 more source

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph, Megan McCune, Riley Bove, Ahmed Abdelhak, Bruce A. C. Cree, Valerie J. Block   +5 more
wiley   +1 more source

Simulation-Based Machine Learning Approach to Classify Accelerated Biological Aging Using Telomere and Epigenetic Markers

Sir Syed University Research Journal of Engineering and Technology
Accelerated biological aging characterized by loss of telomeric iterations, epigenetic modification and persistent inflammation underlies increased risks of age related diseases, but benchmarking with machine learning (ML) methods for the classification
Syed Ibad Hasnain, Muhammad Faris, Hafiza Syeda Yusra Tirmizi, Rabika Kamal, Tariq Javid   +4 more
doaj   +1 more source

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez, Fareshte Erani, Katherine J. Bangen, David G. Coughlin, Douglas Galasko, Kelsey R. Thomas   +5 more
wiley   +1 more source

Prospective association between biological aging and risk of hospital-diagnosed MASLD: evidence from the UK Biobank

Frontiers in Endocrinology
Background and aimsMetabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder linked to increased all-cause and cardiovascular mortality.
Xue Yang, Xue Yang, Sicheng Li, Qingping Xue, Peijing Yan, Qian Li, Yi Gong, Xiayue Fan, Wenzhi Zhu, Shiyi Wu, Shanshan Zhang, Ko Willems van Dijk, Ko Willems van Dijk, Patrick C.N. Rensen, Patrick C.N. Rensen, Ruifang Li-Gao, Yanan Wang, Yanan Wang, Ting Yao   +18 more
doaj   +1 more source

Inflammasome activation and accelerated immune aging in autoimmune disorders [PDF]

Autoimmune diseases, particularly those with early onset such as systemic lupus erythematosus, juvenile idiopathic arthritis, and type 1 diabetes, are paradoxically characterized by molecular and cellular features typically associated with aging.
Mittal, Rahul, Hirani, Khemraj, Saavedra, Danay, Lemos, Joana R. N., Mittal, Mannat   +4 more
core   +1 more source

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the treatment effect of anticoagulation versus antiplatelet therapy in patients ...
Elena Badillo Goicoechea, Patrick Ellsworth, James E. Siegler, James R. Brorson, Christina M. Lineback, Frank G. Conyers, Deborah Kerrigan, Kelsey Eklund, Shadi Yaghi, Farid Khasiyev, Emiliya Melkumova, Collin J. Culbertson, Marissa D'Souza, Dinesh V. Jillella, Patrick Glover, Hassan Aboul‐Nour, Fadi Nahab, Mahan Shahrivari, Simona Nedelcu, David S. Liebeskind, Matthew M. Smith, Aaron Rothstein, Anna Bowman, Alicia Zha, Narendra Kala, Ahmad Abu Qdais, Sami Al Kasab, Mudassir Farooqui, Diana Rojas‐Soto, Yasmin Aziz, Franziska Herpich, Jean‐Philippe Daniel, Sean L. Thompson, Vivek Patel, Thanh N. Nguyen, Siddharth Sehgal, Wenzheng Yu, Wayneho Kam, Russel Van Coevering, Oana M. Dumitrascu, Muhammad Alvi, Balaji Krishnaiah, Setareh Salehi Omran, Guillermo Linares, Eesha Singh, Hamid Ali, Mary Penckofer, Jesse M. Thon, Shani Mannion, Dalia Chahien, Lucia Chen, Fawad Talat, Mehdi Abbasi, Richa Sharma   +53 more
wiley   +1 more source

[Coalition for Aging LGBT Pamphlet]

Pamphlet from the Coalition for Aging LGBT Records (The Dallas Way)
Coalition for Aging LGBT
core   +1 more source

Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging.

, 2006
BACKGROUND: Little is known about the biological mechanisms underlying the excess medical morbidity and mortality associated with mood disorders.
Maser, R S, Wong, K K, Smoller, J W, Pollack, M H, Nierenberg, A A, Simon, N M, Zalta, A K, Fava, M, McNamara, K L   +8 more
core   +1 more source