Results 101 to 110 of about 3,485,354 (289)

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Trauma, adversity, and biological aging: behavioral mechanisms relevant to treatment and theory

Translational Psychiatry
Although stress and adversity are largely universal experiences, people exposed to greater hardship are at increased risk for negative health consequences.
Kyle J. Bourassa, David A. Sbarra
doaj   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Occupational polycyclic aromatic hydrocarbons (PAHs) exposure is associated with accelerated aging trajectories in Chinese coke oven workers

Scientific Reports
Long-term effects of occupational polycyclic aromatic hydrocarbons (PAHs) on biological aging are unclear. A prospective cohort study was conducted from 2019 to 2023, involving 610 coke oven workers and 454 control workers from a water treatment plant ...
Yidong Wang, Shuangxi Geng, Wenyu Wang, Lijun Yuan, Jisheng Nie, Huifang Zhang, Baolong Pan, Qiao Niu   +7 more
doaj   +1 more source

Biological Aging Acceleration in Major Depressive Disorder : A Multi-Omics Analysis

Major depressive disorder (MDD) is linked to a higher risk of premature aging, but the mechanisms underlying this association remain unclear. Using data from two population cohorts (UK Biobank and Finnish Twin Cohort), we evaluate the relationship ...
Lenze, Eric J., Diniz, Breno Satler, Zhao, Shangshu, Vuoksimaa, Eero, Fortinsky, Richard H., Kaprio, Jaakko, Ollikainen, Miina, Kuo, Chia-ling, Xu, Ming, Kuchel, George A., Drouard, Gabin, Kuchel, George A, Fortinsky, Richard H, Lenze, Eric J   +13 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

Multi-discrimination exposure and biological aging: Results from the midlife in the United States study

Brain, Behavior, & Immunity - Health
Discrimination is a social determinant of health and health disparities for which the biological mechanisms remain poorly understood. This study investigated the hypothesis that discrimination contributes to poor health outcomes by accelerating ...
Adolfo G. Cuevas, Steven W. Cole, Daniel W. Belsky, Anna-Michelle McSorley, Jung Min Shon, Virginia W. Chang   +5 more
doaj   +1 more source

The association between secondhand smoke exposure and accelerated biological aging: A population-based study and Mendelian randomization analysis

Tobacco Induced Diseases
Introduction Aging is an irreversible biological process significantly influenced by oxidative stress, which smoking exacerbates. While the impact of direct smoking on aging is well-documented, the association between secondhand smoke (SHS) exposure and ...
Yue Zhu⁺, Yufan Gao⁺, Yangguang Lu⁺, Yukai Wang, Ziyu Pan, Huixiang Sheng, Jiajun Li, Yinuo Chen, Jialing Lou, Feng Chen, Fajing Yang   +10 more
doaj   +1 more source

Other title: Kansas State Advisory Council on Aging report for fiscal years--Other title: Kansas Advisory Council on Aging annual report

, 1979
The reports were prepared with the assistance of the Kansas Department on Aging.; Created in 1977 by the Kansas Act on the Aging, the ACA is represents different geographical, social and ethnic groups, with at least half its members being 60 years of age
Kansas Advisory Council on Aging.
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