Results 61 to 70 of about 3,485,354 (289)

Biological Age Acceleration and Colonic Polyps in Persons under Age 50

Cancer Prevention Research
Abstract Epigenetic clocks can quantify DNA methylation by measuring the methylation levels at specific sites in the genome, which correlate with biological age (BA). Accelerated aging, where BA exceeds chronologic age, has been studied in relation to cancer development, but its utility in ...
Chloe M. Brown, Maria V. Yow, Shria Kumar   +2 more
openaire   +2 more sources

Accelerating aging research: How can we measure the rate of biologic aging? [PDF]

Experimental Gerontology, 2015
Claims of accelerated or premature aging are frequently made. However, the lack of standard criteria for measuring speed of aging makes such claims highly questionable. Because of fundamental gaps in our current understanding of the biological mechanisms of aging, the development of specific phenotypes that are due to aging is difficult and such ...
Joseph B, Margolick, Luigi, Ferrucci
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Association between triglyceride glucose index and biological aging in U.S. adults: National Health and Nutrition Examination Survey

Cardiovascular Diabetology
Background Insulin resistance (IR) has been reported to be associated with aging; however, few studies have investigated the relationship between IR and biological age (BA). The Triglyceride–glucose (TyG) index is a recognized marker of IR.
Li-ya Pan, Li Jin
doaj   +1 more source

CAN HEALTHY LONGEVITY BE ACHIEVED DESPITE ACCELERATED BIOLOGICAL AGING IN INFLAMMATORY RHEUMATIC DISEASES? A GEROSCIENCE-BASED HYPOTHESIS

Anti-Aging Eastern Europe
Inflammatory rheumatic diseases (IRDs) are increasingly recognized as disorders of accelerated biological aging, characterized by chronic inflammation, immunosenescence, cellular senescence, and progressive loss of physiological resilience.
Neslihan Gokcen
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Some molecular-genetic determinants of premature aging in women

Consilium Medicum
Background. Accelerated biological aging is associated with age-related diseases and an increased risk of mortality. Genetic predisposition may be an important factor in this process. Aim.
Elena V. Kudryavtseva, Dinara A. Berezina, Daniil O. Kornilov, Veronika M. Simarzina, Mikhail A. Tryapitsyn, Aleksey A. Bekhter, Vladislav V. Kovalev, Danila L. Zornikov   +7 more
doaj   +1 more source

Acceleration of cardiovascular-biological age by amphetamine exposure is a power function of chronological age [PDF]

Heart Asia, 2017
Background Amphetamine abuse is becoming more widespread internationally. The possibility that its many cardiovascular complications are associated with a prematurely aged cardiovascular system, and indeed biological organism systemically, has not been addressed ...
Albert Stuart Reece, Amanda Norman, Gary Kenneth Hulse   +2 more
openaire   +2 more sources

Accelerated Biological Aging, Genetic Susceptibility, and Non-Alcoholic Fatty Liver Disease: Two Prospective Cohort Studies

Background: Biological aging is considered a vital risk factor for age-related diseases, but its role in non-alcoholic fatty liver disease (NAFLD) remains uncertain.
Huimin Chen, Yuefeng He, Ping Yao, Ying Zhao, Li Chen, Yuhan Tang, Yu Wang   +6 more
core   +1 more source

Accelerated aging in serious mental disorders [PDF]

, 2019
Clinical, epidemiological, and biological evidence raises the possibility that serious mental disorders (SMDs) are associated with accelerated biological aging.
Mellon, Synthia H, Reus, Victor I, Wolkowitz, Owen M, Bersani, Francesco S   +3 more
core   +1 more source