Results 51 to 60 of about 3,485,354 (289)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Biological Aging and Chemotoxicity in Patients with Colorectal Cancer: A Secondary Data Analysis Using EHR Data

Current Oncology
Background: Biological aging influences cancer outcomes, but its changes during chemotherapy and impact on chemotoxicity in colorectal cancer (CRC) remain underinvestigated.
Claire J. Han, Ashley E. Rosko, Jesse J. Plascak, Alai Tan, Anne M. Noonan, Christin E. Burd   +5 more
doaj   +1 more source

Epigenetic Age Acceleration [PDF]

Circulation: Genomic and Precision Medicine, 2018
See Article by Roetker et al Epigenetic age seems like a concept pulled from a futuristic science-fiction movie where a drop of blood is fed into a machine, in which an algorithm churns through an accumulation of chemical groups coating a strand of DNA and spits out an individual’s true age reflecting a lifetime of experiences and exposures ...
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

The relationship between serum uric acid and accelerated aging in middle-aged and older adults: a prospective cohort study based on CHARLS

The Journal of Nutrition, Health and Aging
Objective: This study seeks to determine the association between serum uric acid (SUA) and accelerated aging among middle-aged and older adults in China, as well as assess the relationship between SUA trajectories and the risk of accelerated aging ...
Weiyi Shi, Zihong Cai, Xiaoxu Ren, Juehan Wang, Hang Zhou, Zuobing Chen   +5 more
doaj   +1 more source

Accelerated aging in the brain, epigenetic aging in blood, and polygenic risk for schizophrenia [PDF]

, 2021
Schizophrenia patients show signs of accelerated aging in cognitive and physiological domains. Both schizophrenia and accelerated aging, as measured by MRI brain images and epigenetic clocks, are correlated with increased mortality.
Ori, Anil P S, Schnack, Hugo G., Teeuw, Jalmar, Ori, Anil P.S., Hulshoff Pol, Hilleke E., Brouwer, Rachel M., Hulshoff Pol, Hilleke E, Brouwer, Rachel M, de Zwarte, Sonja M C, Ophoff, Roel A, de Zwarte, Sonja M.C., Ophoff, Roel A., Schnack, Hugo G, Brain, Onderzoeksgroep 1, Anil P.S. Ori, Rachel M. Brouwer, Hilleke E. Hulshoff Pol, Jalmar Teeuw, Hugo G. Schnack, Roel A. Ophoff, Sonja M.C. de Zwarte   +21 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Associations of Physical Frailty, Social Deficits, and Cognitive Impairment with Risk of 45 Incident Non-Communicable Diseases: The Mediating Role of Accelerated Biological Aging—A Prospective Cohort Study

The Journal of Nutrition, Health and Aging
Objectives: Frailty extends beyond a physical construct to encompass cognitive and social functioning. We aimed to assess the associations of these impairments, individually and in combination, with the risk of 45 non-communicable diseases (NCDs), and ...
Bing Pei, Yue Yu, Xinyuan Shen, Yanjie Jia, Jianping Wang, Yihan Zhang, Ying Shi, Wenjing Wang, Fulan Hu, Fan Wang   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Role of Mesenchymal Stem/Stromal Cells (MSCs) and MSC-Derived Extracellular Vesicles (EVs) in Prevention of Telomere Length Shortening, Cellular Senescence, and Accelerated Biological Aging

Bioengineering
Biological aging is defined as a progressive decline in tissue function that eventually results in cell death. Accelerated biologic aging results when the telomere length is shortened prematurely secondary to damage from biological or environmental ...
Myrna Y. Gonzalez Arellano, Matthew VanHeest, Sravya Emmadi, Amal Abdul-Hafez, Sherif Abdelfattah Ibrahim, Ranga P. Thiruvenkataramani, Rasha S. Teleb, Hady Omar, Tulasi Kesaraju, Tarek Mohamed, Burra V. Madhukar, Said A. Omar   +11 more
doaj   +1 more source