Results 31 to 40 of about 3,485,354 (289)

Prenatal Air Pollution and Newborns' Predisposition to Accelerated Biological Aging [PDF]

Obstetrical & Gynecological Survey, 2017
(Abstracted from JAMA Pediatr 2017;171(12):1160–1167) Telomere length (TL) is considered a molecular marker of biological aging. Telomeres shorten with each cellular division, and their length is associated with age-related diseases, lifestyle factors such as smoking, and environmental factors that influence the oxidative stress and ...
Dries S. Martens, Bianca Cox, Bram G. Janssen, Diana B. P. Clemente, Antonio Gasparrini, Charlotte Vanpoucke, Wouter Lefebvre, Harry A. Roels, Michelle Plusquin, Tim S. Nawrot   +9 more
openaire   +4 more sources

EVIDENCE FOR BIOLOGICAL AGE ACCELERATION AND TELOMERE SHORTENING IN COVID19 SURVIVORS [PDF]

International Journal of Molecular Sciences, 2021
ABSTRACT Introduction & Background the SARS-CoV-2 infection determines the COVID19 syndrome characterized, in the worst cases, by severe respiratory distress, pulmonary and cardiac fibrosis, inflammatory cytokines release, and immunosuppression.
Alessia Mongelli, Veronica Barbi, Michela Gottardi Zamperla, Sandra Atlante, Luana Forleo, Marialisa Nesta, Massimo Massetti, Alfredo Pontecorvi, Simona Nanni, Antonella Farsetti, Oronzo Catalano, Maurizio Bussotti, Laura Dalla Vecchia, Tiziana Bachetti, Fabio Martelli, Maria Teresa La Rovere, Carlo Gaetano   +16 more
openaire   +6 more sources

Association between plant-based dietary pattern and biological aging trajectory in a large prospective cohort

BMC Medicine, 2023
Background Aging is a dynamic and heterogeneous process that may better be captured by trajectories of aging biomarkers. Biological age has been advocated as a better biomarker of aging than chronological age, and plant-based dietary patterns have been ...
Sicong Wang, Wenyuan Li, Shu Li, Huakang Tu, Junlin Jia, Wenting Zhao, Andi Xu, Wenxin Xu, Min Kuang Tsai, David Ta-Wei Chu, Chi Pang Wen, Xifeng Wu   +11 more
doaj   +1 more source

Biological Age in COPD Patients Reveals an Accelerated Lung Aging [PDF]

, 2021
Abstract Chronic obstructive pulmonary disease (COPD), the third leading cause of death worldwide, shows striking clinical aging-associated features of lung. We tested the hypothesis that lung biological aging in COPD is accelerated. Biological aging was assessed by mitotic telomere length (TL) and non-mitotic age-dependent methylation changes ...
Manuela Campisi, Filippo Liviero, Piero Maestrelli, Gabriella Guarnieri, Sofia Pavanello   +4 more
openaire   +1 more source

Association between biological aging and periodontitis using NHANES 2009–2014 and mendelian randomization

Scientific Reports
Aging is a recognized risk factor for periodontitis, while biological aging could provide more accurate insights into an individual's functional status. This study aimed to investigate the potential association between biological aging and periodontitis.
Sihong Li, Chang Wen, Xueying Bai, Dong Yang   +3 more
doaj   +1 more source

Interpretable machine learning with SHAP analysis identifies redox-modulating dietary antioxidants for predicting accelerated biological aging

Experimental Gerontology
Background: Aging is a complex biological process characterized by progressive functional decline across multiple physiological systems, and biological age provides a more accurate reflection of an individual's aging status than chronological age ...
Bei Zhang, Xinyu Zhang, Lanyue Ma, Danfei Li, Yijia Li, Sen Lin, Lisheng Peng, Li He   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Skin health and biological aging

Accumulating evidence indicates that biological aging can be accelerated by environmental exposures, collectively called the 'exposome'. The skin, as the largest and most exposed organ, can be viewed as a 'window' for the deep exploration of the exposome
Bulteau Anne-Laure, Watson Rachel EB, Gladyshev Vadim N, Nizard Carine, Neretti Nicola, Robinton Daisy, Church George, Sebastiano Vittorio, Wang Meng C, Auwerx Johan, Couturaud Virginie, Pays Karl, Decottignies Anabelle, Davies Kelvin JA, Crabbe Laure, Woltjen Knut, Furman David, Kennedy Brian K, Furman, David, Neretti, Nicola, Wang, Meng C., Sebastiano, Vittorio, Davies, Kelvin JA, Auwerx, Johan, Woltjen, Knut, Crabbe, Laure, Church, George, Decottignies, Anabelle, Couturaud, Virginie, Davies, Kelvin J.A., Kennedy, Brian K, Bulteau, Anne Laure, Bulteau, Anne-Laure, Gladyshev, Vadim N, Watson, Rachel EB, Wang, Meng C, Gladyshev, Vadim N., Pays, Karl, Nizard, Carine, Kennedy, Brian K., Watson, Rachel E.B., Robinton, Daisy   +41 more
core   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Biological aging and incident cardiovascular diseases in individuals with diabetes: insights from a large prospective cohort study

Cardiovascular Diabetology
Background Biological aging is a critical risk factor of age-related diseases, but its impact on diabetic individuals remains unclear. This study aimed to examine the associations of biological aging with the incident cardiovascular diseases (CVDs) and ...
Zhiwei Zeng, Chunyu Yu, Runze Chen, Zhongchen Li, Peng Wang, Xueying Wang, Xi Li, Zhe Zheng   +7 more
doaj   +1 more source