Results 91 to 100 of about 9,684,773 (259)
Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Biopolymer Degradation Analysis: Accelerated Life Testing Study to Characterize Polylactic Acid Durability. [PDF]
Materials (Basel), 2021 Arias-Nava EH +2 more
europepmc +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Bootstrap-based confidence intervals in partially accelerated life testing [PDF]
, 2017 Accelerated life testing (ALT) is utilized to estimate the underlying failure distribution and related parameters of interest in situations where the components under study are designed for long life and therefore will not yield failure data within a ...
Eshebli, Ahmed Mohamed
core
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Operating channel temperature in GaN HEMTs:DC versus RF accelerated life testing [PDF]
, 2015 Channel temperature is a key parameter for accelerated life testing in GaN HEMTs. It is assumed that self-heating is similar in RF and DC operations and that DC test results can be applied to RF operation.
Kuball, Martin H H +3 more
core +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Effect of terahertz irradiation on DNA damage repair in living cells
FEBS Open Bio, EarlyView.We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno +3 more
wiley +1 more source
Accelerated life testing when a process of production is unstable
The developement of the heredity principle in reliability is discussed. The possible invariants in the generalized additive and multiplicative models were proposed. Estimation of these invariants with application in accelerated life testing is considered.
Nikulin, Mikhail +1 more
core
AxiomsThis study introduces a novel approach to accelerated life test experiments by examining competing risk factors using the Tampered Random Variable (TRV) model. This approach remains extensively unexplored in current research.
Hanan Haj Ahmad +2 more
doaj +1 more source