Results 81 to 90 of about 9,684,773 (259)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Accelerated Life Testing Of Subsea Equipment Under Hydrostatic Pressure [PDF]

, 2010
Accelerated Life Testing (ALT) is an effective method of demonstrating and improving product reliability in applications where the products are expected to perform for a long period of time.
Thiraviam, Amar Raja
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Double-Crossed Step-Stress Accelerated Life Testing for Pneumatic Cylinder

, 2011
This paper discusses the principle and method of Double-Crossed Step-Down-Stress Accelerated Life Testing (DCSDS-ALT) for pneumatic cylinders. As to pneumatic cylinder, the step-down-stress testing failure physics can be described as cumulative ...
Juan Chen, Yong Ling Fu, De Yi Wang, Xiao Ye Qi   +3 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Statistical inferences under step stress partially accelerated life testing based on multiple censoring approaches using simulated and real-life engineering data. [PDF]

Sci Rep, 2023
Rahman A, Kamal M, Khan S, Khan MF, Mustafa MS, Hussam E, Atchadé MN, Al Mutairi A.   +7 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Accelerated life testing effects on CMOS microcircuit characteristics [PDF]

, 1977
Accelerated life tests were performed on CMOS microcircuits to predict their long term reliability. The consistency of the CMOS microcircuit activation energy between the range of 125 C to 200 C and the range 200 C to 250 C was determined.

core  

Journal of Statistical Planning and Inference, v.139,#5, 2009. A special issue on the topic of Degradation, Damage, Fatigue and Accelerated Life Models in Reliability Testing.

, 2009
The ALT'2006 meeting "Degradation, Damage Fatigue and Accelerated Life Models in Reliability Testing" was the first international conference in Europe devoted to accelerated life testing and closely related topics in reliability.
Guerin, Fabrice, Escobar, Luis A., Meeker, William Q., Nikulin, Mikhail   +3 more
core   +1 more source

Parameter Estimation in Step Stress Partially Accelerated Life Testing under Different Types of Censored Data. [PDF]

Comput Intell Neurosci, 2022
Kamal M, Siddiqui SA, Rahman A, Alsuhabi H, Alkhairy I, Barry TS.   +5 more
europepmc   +1 more source