Results 1 to 10 of about 4,823 (247)

Acceptability and Palatability of Novel Orodispersible Minitablets of Enalapril in Children up to the Age of 6 with Heart Failure [PDF]

Journal of Clinical Medicine
Background: Angiotensin-converting enzyme inhibitors, such as enalapril, are foundational in treating pediatric heart failure. However, they are often administered off-label to young children using extemporaneous formulations. This study, conducted as part of the EU-funded Labeling of Enalapril from Neonates up to Adolescents (LENA) project, aimed to ...
Vladislav Vukomanović, Milica Bajcetic   +1 more
exaly   +5 more sources

Evaluating the Acceptability, Swallowability, and Palatability of Film-Coated Mini-Tablet Formulation in Young Children: Results from an Open-Label, Single-Dose, Cross-Over Study

Pharmaceutics, 2023
Mini-tablets are advantageous over liquid formulations in overcoming challenges related to stability, taste, and dosage. This open-label, single-dose, cross-over study investigated the acceptability and safety of drug-free, film-coated mini-tablets in ...
Juliane Munch, Philipp Lustenberger, Viviane Klingmann   +2 more
exaly   +4 more sources

Acceptability, Swallowability, Palatability, and Safety of Multiple Film-Coated Mini-Tablets in Children Aged ≥2–<7 Years: Results of an Open-Label Randomised Study [PDF]

Pharmaceutics, 2023
This single-centre, open-label, randomised, parallel-group study assessed the acceptability, swallowability, palatability, and safety of film-coated, 3 mm diameter mini-tablets in children aged ≥2–
Juliane Münch, Carolin Kloft, Madhi Farhan, Vladislav Fishman, Sining Leng, Hans Martin Bosse, Viviane Klingmann   +6 more
doaj   +3 more sources

Sex Differences in Medicine Acceptability: A New Factor to Be Considered in Medicine Formulation [PDF]

Pharmaceutics, 2019
Palatability is a recognized driver of medicine acceptability in pediatrics but deemed less relevant in older populations due to sensory decline. Preliminary findings from an observational study implicated palatability problems with one Alzheimer’s
Fabrice Ruiz, Alexander Keeley, Catherine Tuleu   +2 more
exaly   +4 more sources

Modernising Orodispersible Film Characterisation to Improve Palatability and Acceptability Using a Toolbox of Techniques

Pharmaceutics, 2022
Orodispersible films (ODFs) have been widely used in paediatric, geriatric and dysphagic patients due to ease of administration and precise and flexible dose adjustments.
Neel Desai, Marc A Masen, Philippa Cann   +2 more
exaly   +6 more sources

A Randomized, Open, Single-Administration, Cross-Over Study to Investigate the Acceptability, Swallowability, Palatability, and Preference of Different Oral Placebo Formulations in Patients with Multiple Sclerosis [PDF]

Pharmaceutics
Background: There is a paucity of systematic investigations of the acceptability and preference of alternative oral drug formulations in multiple sclerosis (MS) patients. The use of appropriate oral dosage forms has the potential to circumvent challenges
Hans Martin Bosse, Kotryna Karosaite, Carolin Kloft, Melanie Schütte, Marc Pawlitzki, Philipp Albrecht, Sharmishtha Chauhan, Isabelle Gallou, Sebastien Chabaud, Tushar Sawai, Haripriya Tumuluri, Manfred Wargenau, Lucas-Sebastian Spitzhorn, Viviane Klingmann   +13 more
doaj   +2 more sources

Acceptability of minitablets in soft food. A randomised cross-over study in children [PDF]

Frontiers in Pharmacology
ObjectiveTo evaluate the acceptability of placebo minitablets mixed with different volumes of soft food in children aged 6 months to 7 years.MethodsIn this UK hospital-based, randomised cross-over study, children received placebo minitablets in yoghurt ...
Jennifer C. Duncan, Rebecca Page, Janet Clark, Gabrielle Seddon, Joy Slater, Andrea Gill, Silothabo Dliso, Udeme Ohia, Nikolaos Skoutelis, Leonie Wagner-Hattler, Adrian Baumgartner, Angela Sprunk, Peter Kühl, Louise Bracken   +13 more
doaj   +2 more sources

Oral Dosage Forms for Children: Acceptability and Palatability

Yakugaku Zasshi, 2015
Children generally reject taking medicine which does not have a favorable shape, taste, flavor, etc. However, if a child who needs to take a medicine, rejects taking it, he might never recover from his condition. When a child is unable to take medicine orally, it is intravenously administered, and he and his caregivers then may experience stress ...
exaly   +5 more sources

A randomised controlled crossover study to assess adherence and palatability of a porridge supplement compared to a drink-based supplement in hospitalised older adults at risk of malnutrition [PDF]

Journal of Nutritional Science
Oral nutritional supplements (ONS) are essential adjuncts in managing malnutrition in hospitalised older people. This study aimed to explore the adherence and palatability of a new porridge supplement (PS) compared to a standard drink-based supplement ...
Samantha Jane Meredith, Kate A. Sheppard, Philip C. Calder, Harnish P. Patel, Stephen Eu Ruen Lim   +4 more
doaj   +2 more sources

Acceptability of oral liquid pharmaceutical products in older adults: palatability and swallowability issues [PDF]

BMC Geriatrics, 2019
Background In institutional care, oral liquid pharmaceutical products are widely prescribed for older patients, especially for those with swallowing disorders.
Emilie Belissa, Thibault Vallet, Sandra Laribe-Caget, Alain Chevallier, François-Xavier Chedhomme, Fattima Abdallah, Nathalie Bachalat, Sid-Ahmed Belbachir, Imad Boulaich, Vanessa Bloch, Anne Delahaye, Mathieu Depoisson, Amélie Dufaÿ Wojcicki, Stéphane Gibaud, Anne-Sophie Grancher, Caroline Guinot, Celia Lachuer, Laurent Lechowski, Patrick Leglise, Abdel Mahiou, Sylvie Meaume, Corinne Michel, Hugues Michelon, Yann Orven, Ines Perquy, Matthieu Piccoli, Maïté Rabus, Annie-Claude Ribemont, Jean-Paul Rwabihama, Jean-Hugues Trouvin, Fabrice Ruiz, Vincent Boudy   +31 more
doaj   +4 more sources