Results 41 to 50 of about 77,670 (298)
In silico comparison of spike protein-ACE2 binding affinities across species; significance for the possible origin of the SARS-CoV-2 virus [PDF]
Scientific Reports. 2021 Jun 24;11(1):13063. PMID: 34168168, 2020 The devastating impact of the COVID-19 pandemic caused by SARS coronavirus 2 (SARS CoV 2) has raised important questions about viral origin, mechanisms of zoonotic transfer to humans, whether companion or commercial animals can act as reservoirs for infection, and why there are large variations in SARS-CoV-2 susceptibilities across animal species ...
arxiv +1 more source
ACE2: The Only Thing That Matters?
American Journal of Respiratory and Critical Care Medicine, 2020 In December 2019, cases of a respiratory disease were reported in Hubei Province, China, caused by a positive-sense RNA virus from the family Coronaviridae Subsequently, the disease was called coronavirus disease (COVID-19) and the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) The outcome of infection with SARS-CoV-2 is highly ...
Raul Y. Sanchez-David +3 more
openaire +3 more sources
ACE2 Shedding and the Role in COVID-19 [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Angiotensin converting enzyme 2 (ACE2), a transmembrane glycoprotein, is an important part of the renin-angiotensin system (RAS). In the COVID-19 epidemic, it was found to be the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2).
Jieqiong Wang, Huiying Zhao, Youzhong An
openaire +3 more sources
iMeta, Volume 1, Issue 4, December 2022., 2022 TCM‐Suite platform is composed of two sub‐databases, Holmes‐Suite and Watson‐Suite. Holmes‐Suite database covers six marker genes, resulting in 235,470 kinds of biological ingredients. Watson‐Suite retrieved massive data for mining the “herb‐compound‐protein‐disease” interpretation.
Pengshuo Yang +8 more
wiley +1 more source
Immunocytochemical Assessment of ACE2 and TMPRSS2 in Nasopharyngeal Swabs from SARS-CoV-2 Patients
Frontiers in Bioscience-Landmark, 2022 Background: SARS-CoV-2 is a positive-sense single-stranded RNA virus. It is enveloped by four structural proteins. The entry of the virus into the host cells is mediated by spike protein binding to the angiotensin converting enzyme 2 (ACE2) and ...
Karla Beatríz Peña +9 more
doaj +1 more source
Soluble ACE2 Is Filtered into the Urine
Kidney360, 2022 Key Points Combining unique genetic and surgical models, we demonstrate that both renal and systemic sources contribute to angiotensin-converting enzyme 2 (ACE2) detected in the urine in angiotensin II–mediated hypertension.Micropuncture coupled with nanoproteomics confirm detection of ACE2 in ...
Jonathan W. Nelson +11 more
openaire +2 more sources
ACE2 level as a marker of CVD [PDF]
Nature Reviews Cardiology, 2020 Higher levels of angiotensin-converting enzyme 2 in plasma are associated with a greater risk of major cardiovascular disease events, according to a global, population-based study.
openaire +2 more sources
COVID-19 and cardiovascular system—a comprehensive review [PDF]
Reviews in Cardiovascular Medicine, 2021 Coronavirus disease 2019 (COVID-19), a mystified cryptic virus has challenged the mankind that has brought life to a standstill. Catastrophic loss of life, perplexed healthcare system and the downfall of global economy are some of the outcomes of this
Ibrahim AlShahrani +7 more
doaj +1 more source
Baghdad Journal of Biochemistry and Applied Biological Sciences, 2021 Background: Epidemiological studies revealed there is a difference in susceptibility to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of differences in gender with age and males being more inflicted. There is a clear
Ahmed A. Suleiman +3 more
doaj +1 more source
A new approach for extracting information from protein dynamics
Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 2, Page 183-195, February 2023., 2023 Abstract Increased ability to predict protein structures is moving research focus towards understanding protein dynamics. A promising approach is to represent protein dynamics through networks and take advantage of well‐developed methods from network science.
Jenny Liu +2 more
wiley +1 more source