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Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 [PDF]

, 2020
Background and purpose Infections with coronaviruses are not always confined to the respiratory tract and various neurological manifestations have been reported.
Boon, Paul, De Herdt, Veerle, Garrez, Ieme, Hemelsoet, Dimitri, Laureys, Guy, Raedt, Robrecht, Vonck, Kristl   +6 more
core   +2 more sources

Molecular Aspects of Spike–ACE2 Interaction [PDF]

Encyclopedia, 2022
A new betacoronavirus (CoV-2) is responsible for the pandemic of severe acute respiratory syndrome (SARS) that began in China at the end of 2019, today known as COronaVIrus Disease 2019 (COVID-19). Subsequent studies confirmed the human angiotensin-converting enzyme 2 (hACE2) as the main cell receptor of spike trimeric glycoprotein, located on the ...
Luigi De Masi, Maria Antonia Argenio, Deborah Giordano, Angelo Facchiano   +3 more
openaire   +3 more sources

Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis

Journal of Pathology, 2004
Severe acute respiratory syndrome (SARS) is an acute infectious disease that spreads mainly via the respiratory route. A distinct coronavirus (SARS‐CoV) has been identified as the aetiological agent of SARS. Recently, a metallopeptidase named angiotensin‐
I. Hamming, W. Timens, Marian Bulthuis, A. Lely, G. Navis, H. Goor   +5 more
semanticscholar   +1 more source

A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

Science, 2020
An antibody defense against COVID-19 One of the responses of the immune system to invading viruses is the production of antibodies. Some of these are neutralizing, meaning that they prevent the virus from being infectious, and can thus be used to treat ...
Yan Wu, Feiran Wang, Chenguang Shen, Weiyu Peng, Delin Li, Cheng Zhao, Z. Li, Shihua Li, Y. Bi, Yang Yang, Y. Gong, Haixia Xiao, Z. Fan, Shuguang Tan, Guizhen Wu, W. Tan, Xuancheng Lu, Changfa Fan, Qihui Wang, Yingxia Liu, Chen Zhang, J. Qi, G. Gao, F. Gao, Lei Liu   +24 more
semanticscholar   +1 more source

SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection

medRxiv, 2021
The emergence of the Omicron variant (1) of SARS-CoV-2 in November 2021 in South Africa has raised concerns that, based on the large number of mutations in the spike protein and elsewhere on the virus (https://covdb.stanford.edu/page/mutation-viewer ...
S. Cele, Laurelle Jackson, K. Khan, D. Khoury, T. Moyo-Gwete, H. Tegally, C. Scheepers, D. Amoako, F. Karim, M. Bernstein, G. Lustig, D. Archary, Muneerah Smith, Y. Ganga, Z. Jule, K. Reedoy, D. Cromer, J. E. San, Shi-Hsia Hwa, J. Giandhari, J. Blackburn, B. Gosnell, S. Karim, W. Hanekom, A. von Gottberg, J. Bhiman, R. Lessells, M. S. Moosa, M. Davenport, Túlio de Oliveira, P. Moore, A. Sigal   +31 more
semanticscholar   +1 more source

Evaluation of COVID-19 based on ACE2 expression in normal and cancer patients

Open Medicine, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is now a serious public health problem. Angiotensin-converting enzyme 2 (ACE2) recognized as the receptor of SARS-CoV is also necessary for SARS-CoV-2.
Ren Peng, Gong Caifeng, Ma Shaohua
doaj   +1 more source

Sitagliptin: a potential drug for the treatment of COVID-19?

Acta Pharmaceutica, 2021
Recently, an outbreak of a fatal coronavirus, SARS-CoV-2, has emerged from China and is rapidly spreading worldwide. Possible interaction of SARS-CoV-2 with DPP4 peptidase may partly contribute to the viral pathogenesis.
Bardaweel Sanaa K., Hajjo Rima, Sabbah Dima A.   +2 more
doaj   +1 more source

Homology modeling and mutation prediction of ACE2 from COVID-19 [PDF]

Pharmaciana, 2021
SARS-CoV-2 has become a pandemic in the world. The virus binds to the Angiotensin-Converting Enzyme 2 (ACE2) receptor, which is found in epithelial cells such as in the lungs, to generate the pathology of COVID-19.
Purnawan Pontana Putra, Annisa Fauzana, Khairunnisa Assyifa Salva, Maya Sofiana, Intan Permata Sari, Henny Lucida   +5 more
doaj   +1 more source

Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK1/2 and cell proliferation via Gαq-mediated mechanism [PDF]

, 2014
Dimerization of G protein-coupled receptors (GPCRs) is crucial for receptor function including agonist affinity, efficacy, trafficking and specificity of signal transduction, including G protein coupling.
Bai, B, Cai, X, Chen, J, Chen, J, Jiang, Y, Karteris, E   +5 more
core   +2 more sources

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Nature Medicine, 2005
During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world. A new coronavirus (SARS-CoV) was identified as the SARS pathogen, which triggered severe pneumonia and acute ...
K. Kuba, Y. Imai, Shuan Rao, Hong Gao, F. Guo, Bin Guan, Yi Huan, Peng‐fei Yang, Yanli Zhang, Wei Deng, L. Bao, Binlin Zhang, Guang Liu, Z. Wang, M. Chappell, Yan-xin Liu, D. Zheng, A. Leibbrandt, T. Wada, Arthur S Slutsky, De-Pei Liu, C. Qin, Chengyu Jiang, J. Penninger   +23 more
semanticscholar   +1 more source