Targeting acetyl-CoA carboxylase 1 for cancer therapy [PDF]
Frontiers in Pharmacology, 2023 Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu +5 more
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Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program [PDF]
Cell Reports, 2023 Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl-CoA
Adilson Guilherme +18 more
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Regulation of purified rat liver acetyl CoA carboxylase by phosphorylation
Journal of Lipid Research, 1983 Acetyl CoA carboxylase was purified from liver of fasted-refed rats to near homogeneity, based on electrophoretic analysis and biotin content. These preparations contained an endogenous protein kinase that catalyzed the transfer of radioactive phosphate ...
J B Allred, G J Harris, J Goodson
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Purification of Native Acetyl CoA Carboxylase From Mammalian Cells [PDF]
Bio-ProtocolFatty acid (FA) biosynthesis is a crucial cellular process that converts nutrients into metabolic intermediates necessary for membrane biosynthesis, energy storage, and the production of signaling molecules. Acetyl-CoA carboxylase (ACACA) plays a pivotal
Yaxue Sun +3 more
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Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut [PDF]
BMC Genomics, 2023 Background Polyadenylation is a crucial process that terminates mRNA molecules at their 3′-ends. It has been observed that alternative polyadenylation (APA) can generate multiple transcripts from a single gene locus, each with different polyadenylation ...
Zhenying Peng +7 more
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Frontiers in Microbiology, 2021 Ascomycin (FK520) is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. In this study, we demonstrated that the inactivation of GlnB, a signal transduction protein belonging to the PII family, can increase the ...
Jianping Wen
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Plant acetyl-CoA carboxylase: The homomeric form and the heteromeric form [PDF]
BBA AdvancesAcross the domains of life, the enzyme acetyl-CoA carboxylase (ACC) converts HCO3−, ATP, and acetyl-CoA to malonyl-CoA, ADP, and Pi. Malonyl-CoA is the building block for all de novo fatty acid biosynthesis.
Dilawar Niazi, Greg B.G. Moorhead
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Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity [PDF]
mBioAcetyl-CoA carboxylases (ACCs) convert acetyl-CoA to malonyl-CoA, a key step in fatty acid biosynthesis and autotrophic carbon fixation pathways. Three functionally distinct components, biotin carboxylase (BC), biotin carboxyl carrier protein (BCCP), and
Jiejie Shen +10 more
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Solution Structure and NMR Chemical Shift Perturbations of the Arabidopsis BCCP1 Identify Intersubunit Interactions Potentially Involved in the Assembly of the Heteromeric Acetyl‐CoA Carboxylase [PDF]
Plant DirectBiotin carboxyl carrier protein (BCCP) is a subunit of the heteromeric acetyl‐CoA carboxylase (htACCase), and it chemically links the two half‐reactions that constitute the formation of malonyl‐CoA from acetyl‐CoA, a critical reaction in fatty acid ...
Kiran‐Kumar Shivaiah +3 more
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Zhongguo youzhi, 2023 为了探究细菌异质性乙酰辅酶A羧化酶β亚基生物活性及其对乙酰辅酶A羧化酶酶活影响，以高产油核桃内生细菌B. subtilis HB1310基因组DNA为模板，利用PCR技术扩增其乙酰辅酶A羧化酶羧基转移酶β亚基（β-CT）基因（acb基因），构建pET-28a-acb载体并在E. coli BL21中表达，进一步对乙酰辅酶A羧化酶acb基因的诱导表达条件进行了优化。结果表明：乙酰辅酶A羧化酶acb基因在E.
许思远，张永贵，赵沛，曹娟娟，张琴XU Siyuan，ZHANG Yonggui，ZHAO Pei，CAO Juanjuan，ZHANG Qin
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