Targeting acetyl-CoA carboxylase 1 for cancer therapy [PDF]
Frontiers in Pharmacology, 2023 Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu +5 more
doaj +3 more sources
Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models [PDF]
Nature Medicine, 2016 Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but ...
Matthew J Kolar +2 more
exaly +4 more sources
Chemical Genetics of Acetyl-CoA Carboxylases [PDF]
Molecules, 2013 Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for ...
Xuyu Zu +9 more
doaj +7 more sources
Enhancement of docosahexaenoic acid production by overexpression of ATP-citrate lyase and acetyl-CoA carboxylase in Schizochytrium sp. [PDF]
Biotechnology for Biofuels, 2020 Docosahexaenoic acid (DHA) is an important omega-3 long-chain polyunsaturated fatty acid that has a variety of physiological functions for infant development and human health.
Han Xiao +3 more
openalex +2 more sources
Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase. [PDF]
Sci AdvHuman acetyl-CoA carboxylases (ACCs) catalyze the carboxylation of acetyl-CoA, which is the rate-limiting step in fatty acid synthesis. The molecular mechanism underlying the dynamic organization of ACCs is largely unknown.
Zhou F +5 more
europepmc +2 more sources
Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism. [PDF]
Sci Adv, 2022 Acetyl-CoA carboxylase (ACC) regulates lipid synthesis; however, its role in inflammatory regulation in macrophages remains unclear. We generated mice that are deficient in both ACC isoforms in myeloid cells.
Yeudall S +9 more
europepmc +2 more sources
The dynamic organization of fungal acetyl-CoA carboxylase [PDF]
Nature Communications, 2016 Acetyl-CoA carboxylases are central regulatory hubs of fatty acid metabolism and are important targets for drug development in obesity and cancer. Here, the authors demonstrate that the regulation of these highly dynamic enzymes in fungi is governed by a
Moritz Hunkeler +4 more
doaj +2 more sources
Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization [PDF]
Genetics, 2022 Acetyl-CoA Carboxylase 1 catalyzes the conversion of acetyl-CoA to malonyl-CoA, the committed step of de novo fatty acid synthesis. As a master regulator of lipid synthesis, acetyl-CoA carboxylase 1 has been proposed to be a therapeutic target for ...
Baetz, K. +5 more
core +2 more sources
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program [PDF]
Cell Reports, 2023 Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl-CoA
Adilson Guilherme +18 more
doaj +2 more sources
Nature Communications, 2020 In plants, light-dependent activation fatty acid synthesis (FAS) is mediated in part by acetyl-CoA carboxylase (ACCase). Here the authors identify a family of genes encoding carboxyltransferase interactors that attenuate FAS in the light by docking ...
Yajin Ye +7 more
doaj +2 more sources