Results 1 to 10 of about 38,176 (241)

Increasing the Ascomycin Yield by Relieving the Inhibition of Acetyl/Propionyl-CoA Carboxylase by the Signal Transduction Protein GlnB

Frontiers in Microbiology, 2021
Ascomycin (FK520) is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. In this study, we demonstrated that the inactivation of GlnB, a signal transduction protein belonging to the PII family, can increase the ...
Pan Wang, Pan Wang, Pan Wang, Xin Wang, Xin Wang, Xin Wang, Ying Yin, Ying Yin, Ying Yin, Mingliang He, Mingliang He, Mingliang He, Wei Tan, Wei Tan, Wei Tan, Wenting Gao, Wenting Gao, Wenting Gao, Jianping Wen, Jianping Wen, Jianping Wen   +20 more
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Targeting acetyl-CoA carboxylase 1 for cancer therapy [PDF]

Frontiers in Pharmacology, 2023
Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu, Qingzhu Nie, Ziyi Wang, Yu Di, Xiaolong Chen, Kaiming Ren   +5 more
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Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program [PDF]

Cell Reports, 2023
Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl-CoA
Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech   +18 more
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Chemical Genetics of Acetyl-CoA Carboxylases [PDF]

Molecules, 2013
Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for ...
Xuyu Zu, Jing Zhong, Dixian Luo, Jingjing Tan, Qinghai Zhang, Ying Wu, Jianghua Liu, Renxian Cao, Gebo Wen, Deliang Cao   +9 more
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Platelet Acetyl-CoA Carboxylase Phosphorylation

JACC: Basic to Translational Science, 2019
Summary: Adenosine monophosphate–activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway.
Shakeel Kautbally, MD, Sophie Lepropre, PhD, Marie-Blanche Onselaer, PhD, Astrid Le Rigoleur, MD, Audrey Ginion, MS, Christophe De Meester de Ravenstein, PhD, Jerome Ambroise, PhD, Karim Z. Boudjeltia, PhD, Marie Octave, MS, Odile Wéra, MS, Alexandre Hego, BSc, Joël Pincemail, PhD, Jean-Paul Cheramy-Bien, Thierry Huby, PhD, Martin Giera, PhD, Bernhard Gerber, MD, PhD, Anne-Catherine Pouleur, MD, PhD, Bruno Guigas, PhD, Jean-Louis Vanoverschelde, MD, PhD, Joelle Kefer, MD, PhD, Luc Bertrand, PhD, Cécile Oury, PhD, Sandrine Horman, PhD, Christophe Beauloye, MD, PhD   +23 more
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Acetyl-CoA Carboxylases and Diseases

Frontiers in Oncology, 2022
Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 localizes in the cytosol and acts as the first and rate-limiting enzyme in the de novo fatty acid synthesis pathway.
Yu Wang, Weixing Yu, Sha Li, Dingyuan Guo, Jie He, Jie He, Yugang Wang, Yugang Wang   +7 more
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产油核桃内生细菌乙酰辅酶A羧化酶acb基因 克隆及优化表达Cloning and expression optimization of acetyl-CoA carboxylase acb gene from oil-producing walnut endophyte

Zhongguo youzhi, 2023
为了探究细菌异质性乙酰辅酶A羧化酶β亚基生物活性及其对乙酰辅酶A羧化酶酶活影响，以高产油核桃内生细菌B. subtilis HB1310基因组DNA为模板，利用PCR技术扩增其乙酰辅酶A羧化酶羧基转移酶β亚基（β-CT）基因（acb基因），构建pET-28a-acb载体并在E. coli BL21中表达，进一步对乙酰辅酶A羧化酶acb基因的诱导表达条件进行了优化。结果表明：乙酰辅酶A羧化酶acb基因在E.
许思远，张永贵，赵沛，曹娟娟，张琴XU Siyuan，ZHANG Yonggui，ZHAO Pei，CAO Juanjuan，ZHANG Qin
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Expression of Yarrowia lipolytica acetyl-CoA carboxylase in Saccharomyces cerevisiae and its effect on in-vivo accumulation of Malonyl-CoA

Computational and Structural Biotechnology Journal, 2022
Malonyl-CoA is an energy-rich molecule formed by the ATP-dependent carboxylation of acetyl coenzyme A catalyzed by acetyl-CoA carboxylase. This molecule is an important precursor for many biotechnologically interesting compounds such as flavonoids ...
Humberto Pereira, Flávio Azevedo, Lucília Domingues, Björn Johansson   +3 more
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Neonatal Vitamin C and Cysteine Deficiencies Program Adult Hepatic Glutathione and Specific Activities of Glucokinase, Phosphofructokinase, and Acetyl-CoA Carboxylase in Guinea Pigs’ Livers

Antioxidants, 2021
Premature neonates are submitted to an early-life oxidative stress from parenteral nutrition, which is vitamin C (VC) deficient and induces low endogenous levels of glutathione.
Vitor Teixeira, Ibrahim Mohamed, Jean-Claude Lavoie   +2 more
doaj   +1 more source

Hypothalamic inhibition of acetyl-CoA carboxylase stimulates hepatic counter-regulatory response independent of AMPK activation in rats. [PDF]

PLoS ONE, 2013
BACKGROUND: Hypothalamic AMPK acts as a cell energy sensor and can modulate food intake, glucose homeostasis, and fatty acid biosynthesis. Intrahypothalamic fatty acid injection is known to suppress liver glucose production, mainly by activation of ...
Gustavo A Santos, Vinícius D Pereira, Erika A F R Roman, Leticia Ignacio-Souza, Daniele C Vitorino, Rodrigo Ferreira de Moura, Daniela S Razolli, Adriana S Torsoni, Licio A Velloso, Marcio A Torsoni   +9 more
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