The dynamic organization of fungal acetyl-CoA carboxylase [PDF]
Nature Communications, 2016 AbstractAcetyl-CoA carboxylases (ACCs) catalyse the committed step in fatty-acid biosynthesis: the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. They are important regulatory hubs for metabolic control and relevant drug targets for the treatment of the metabolic syndrome and cancer.
Hunkeler, Moritz +4 more
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Chemical Genetics of Acetyl-CoA Carboxylases [PDF]
Molecules, 2013 Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of drugs for diabetes, obesity and cancers.
Xuyu Zu +9 more
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Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization [PDF]
Genetics, 2022 Acetyl-CoA Carboxylase 1 catalyzes the conversion of acetyl-CoA to malonyl-CoA, the committed step of de novo fatty acid synthesis. As a master regulator of lipid synthesis, acetyl-CoA carboxylase 1 has been proposed to be a therapeutic target for ...
Baetz, K. +5 more
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Expression of genes encoding acetyl-CoA carboxylase, biotin synthase, and acetyl-CoA generating enzymes in Arabidopsis thaliana [PDF]
, 1997 Acetyl-CoA carboxylase catalyzes the formation of malonyl-CoA from acetyl-CoA. The four genes encoding heteromeric acetyl-CoA carboxylase are coordinately expressed in leaves, flowers, and developing siliques and embryos. The highest expression occurs in
Ke, Jinshan
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Acetyl-CoA Carboxylases and Diseases
Frontiers in Oncology, 2022 Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 localizes in the cytosol and acts as the first and rate-limiting enzyme in the de novo fatty acid synthesis pathway.
Yu Wang +7 more
openaire +3 more sources
Regulation of acetyl-coA carboxylase: properties of coA activation of acetyl-coA carboxylase. [PDF]
Proceedings of the National Academy of Sciences, 1980 Acetyl-CoA carboxylase [acetyl-CoA:carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] is activated by physiological concentrations of CoA. The CoA concentration dependency of this activation is sigmoidal; below 60 microM there is little or no activation, but the activation observed between 60 and 120 microM indicates that small changes in the ...
Li-An Yeh, Ki-Han Kim
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Purification and characterisation of an insulin-stimulated protein-serine kinase which phosphorylates acetyl-CoA carboxylase [PDF]
, 1998 An insulin-stimulated protein kinase specific for acetyl-CoA carboxylase has been purified from rat epididymal adipose tissue using Mono-Q chromatography.
Denton, R.M, Heesom, K.J, Moule, S.K
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The Distinctive Regulatory Mechanisms of Bacterial Acetyl-CoA Carboxylase [PDF]
, 2018 Metabolic Regulation is a complex system used to control cellular metabolism in response to conditions in the cell’s environment. For most enzymes, the cell can rely upon a minimal amount of regulation; however, critical enzymes, such as acetyl-CoA ...
Evans, Alexandra Leigh
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Avidin as a probe of the conformational changes induced in pyruvate carboxylase by acetyl-CoA and pyruvate [PDF]
, 1986 Sheep liver pyruvate carboxylase was mixed with avidin at a molar ratio of 1:1 in the presence of various combinations of the components of the assay systems required for either the acetyl-CoA-dependent or the acetyl-CoA-independent activity and ...
Attwood, Paul V. +2 more
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Complex formation and regulation of Escherichia coli acetyl-CoA carboxylase [PDF]
, 2013 Acetyl-CoA carboxylase is a biotin-dependent, multifunctional enzyme that catalyzes the first committed step in fatty acid synthesis. The Escherichia coli enzyme is composed of a homodimeric biotin carboxylase, biotinylated biotin carboxyl carrier ...
Broussard, Tyler Craig
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