Results 1 to 10 of about 55,990 (196)

Targeting acetyl-CoA carboxylase 1 for cancer therapy [PDF]

Frontiers in Pharmacology, 2023
Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu, Qingzhu Nie, Ziyi Wang, Yu Di, Xiaolong Chen, Kaiming Ren   +5 more
doaj   +3 more sources

Docking of acetyl-CoA carboxylase to the plastid envelope membrane attenuates fatty acid production in plants

Nature Communications, 2020
In plants, light-dependent activation fatty acid synthesis (FAS) is mediated in part by acetyl-CoA carboxylase (ACCase). Here the authors identify a family of genes encoding carboxyltransferase interactors that attenuate FAS in the light by docking ...
Yajin Ye, Krisztina Nikovics, Alexandra To, Loïc Lepiniec, Eric T. Fedosejevs, Steven R. Van Doren, Sébastien Baud, Jay J. Thelen   +7 more
doaj   +2 more sources

Purification of Native Acetyl CoA Carboxylase From Mammalian Cells [PDF]

Bio-Protocol
Fatty acid (FA) biosynthesis is a crucial cellular process that converts nutrients into metabolic intermediates necessary for membrane biosynthesis, energy storage, and the production of signaling molecules. Acetyl-CoA carboxylase (ACACA) plays a pivotal
Yaxue Sun, Jiachen Li, Lianmei Zhao, Hongtao Zhu   +3 more
doaj   +2 more sources

Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut [PDF]

BMC Genomics, 2023
Background Polyadenylation is a crucial process that terminates mRNA molecules at their 3′-ends. It has been observed that alternative polyadenylation (APA) can generate multiple transcripts from a single gene locus, each with different polyadenylation ...
Zhenying Peng, Shuang Yu, Jingjing Meng, Kai-Hua Jia, Jialei Zhang, Xinguo Li, Wenwei Gao, Shubo Wan   +7 more
doaj   +2 more sources

Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

Nature Medicine, 2016
Continuous de novo fatty acid synthesis is a common feature of cancer that is required to meet the biosynthetic demands of a growing tumor. This process is controlled by the rate-limiting enzyme acetyl-CoA carboxylase (ACC), an attractive but ...
Matthew J Kolar, Martina Wallace, Portia S Lombardo   +2 more
exaly   +2 more sources

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program [PDF]

Cell Reports, 2023
Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl-CoA
Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech   +18 more
doaj   +2 more sources

Increasing the Ascomycin Yield by Relieving the Inhibition of Acetyl/Propionyl-CoA Carboxylase by the Signal Transduction Protein GlnB

Frontiers in Microbiology, 2021
Ascomycin (FK520) is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. In this study, we demonstrated that the inactivation of GlnB, a signal transduction protein belonging to the PII family, can increase the ...
Jianping Wen
exaly   +3 more sources

Regulation of purified rat liver acetyl CoA carboxylase by phosphorylation

Journal of Lipid Research, 1983
Acetyl CoA carboxylase was purified from liver of fasted-refed rats to near homogeneity, based on electrophoretic analysis and biotin content. These preparations contained an endogenous protein kinase that catalyzed the transfer of radioactive phosphate ...
J B Allred, G J Harris, J Goodson
doaj   +2 more sources

Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl–CoA carboxylase inhibition and AMP-activated protein kinase activation [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2002
gACRP30, the globular subunit of adipocyte complement-related protein of 30 kDa (ACRP30), improves insulin sensitivity and increases fatty acid oxidation. The mechanism by which gACRP30 exerts these effects is unknown.
Eva Tomás, Tsu‐Shuen Tsao, Asish K. Saha, Heather E. Murrey, Cheng Zhang, Samar I. Itani, Harvey F. Lodish, Neil B. Ruderman   +7 more
openalex   +2 more sources

Plant acetyl-CoA carboxylase: The homomeric form and the heteromeric form [PDF]

BBA Advances
Across the domains of life, the enzyme acetyl-CoA carboxylase (ACC) converts HCO3−, ATP, and acetyl-CoA to malonyl-CoA, ADP, and Pi. Malonyl-CoA is the building block for all de novo fatty acid biosynthesis.
Dilawar Niazi, Greg B.G. Moorhead
doaj   +2 more sources