Results 1 to 10 of about 36,991 (155)

Targeting acetyl-CoA carboxylase 1 for cancer therapy [PDF]

Frontiers in Pharmacology, 2023
Metabolic adaptation is an emerging hallmark of tumors. De novo fatty acid synthesis is an important metabolic process to produce metabolic intermediates for energy storage, biosynthesis of membrane lipids and generation of signaling molecules.
Yong Yu, Qingzhu Nie, Ziyi Wang, Yu Di, Xiaolong Chen, Kaiming Ren   +5 more
doaj   +2 more sources

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program [PDF]

Cell Reports, 2023
Summary: Disruption of adipocyte de novo lipogenesis (DNL) by deletion of fatty acid synthase (FASN) in mice induces browning in inguinal white adipose tissue (iWAT). However, adipocyte FASN knockout (KO) increases acetyl-coenzyme A (CoA) and malonyl-CoA
Adilson Guilherme, Leslie A. Rowland, Nicole Wetoska, Emmanouela Tsagkaraki, Kaltinaitis B. Santos, Alexander H. Bedard, Felipe Henriques, Mark Kelly, Sean Munroe, David J. Pedersen, Olga R. Ilkayeva, Timothy R. Koves, Lauren Tauer, Meixia Pan, Xianlin Han, Jason K. Kim, Christopher B. Newgard, Deborah M. Muoio, Michael P. Czech   +18 more
doaj   +2 more sources

Purification of Native Acetyl CoA Carboxylase From Mammalian Cells [PDF]

Bio-Protocol
Fatty acid (FA) biosynthesis is a crucial cellular process that converts nutrients into metabolic intermediates necessary for membrane biosynthesis, energy storage, and the production of signaling molecules. Acetyl-CoA carboxylase (ACACA) plays a pivotal
Yaxue Sun, Jiachen Li, Lianmei Zhao, Hongtao Zhu   +3 more
doaj   +2 more sources

Alternative polyadenylation regulates acetyl-CoA carboxylase function in peanut [PDF]

BMC Genomics, 2023
Background Polyadenylation is a crucial process that terminates mRNA molecules at their 3′-ends. It has been observed that alternative polyadenylation (APA) can generate multiple transcripts from a single gene locus, each with different polyadenylation ...
Zhenying Peng, Shuang Yu, Jingjing Meng, Kai-Hua Jia, Jialei Zhang, Xinguo Li, Wenwei Gao, Shubo Wan   +7 more
doaj   +2 more sources

Plant acetyl-CoA carboxylase: The homomeric form and the heteromeric form [PDF]

BBA Advances
Across the domains of life, the enzyme acetyl-CoA carboxylase (ACC) converts HCO3−, ATP, and acetyl-CoA to malonyl-CoA, ADP, and Pi. Malonyl-CoA is the building block for all de novo fatty acid biosynthesis.
Dilawar Niazi, Greg B.G. Moorhead
doaj   +2 more sources

Chemical Genetics of Acetyl-CoA Carboxylases [PDF]

Molecules, 2013
Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for ...
Xuyu Zu, Jing Zhong, Dixian Luo, Jingjing Tan, Qinghai Zhang, Ying Wu, Jianghua Liu, Renxian Cao, Gebo Wen, Deliang Cao   +9 more
doaj   +3 more sources

Platelet Acetyl-CoA Carboxylase Phosphorylation

JACC: Basic to Translational Science, 2019
Summary: Adenosine monophosphate–activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway.
Shakeel Kautbally, MD, Sophie Lepropre, PhD, Marie-Blanche Onselaer, PhD, Astrid Le Rigoleur, MD, Audrey Ginion, MS, Christophe De Meester de Ravenstein, PhD, Jerome Ambroise, PhD, Karim Z. Boudjeltia, PhD, Marie Octave, MS, Odile Wéra, MS, Alexandre Hego, BSc, Joël Pincemail, PhD, Jean-Paul Cheramy-Bien, Thierry Huby, PhD, Martin Giera, PhD, Bernhard Gerber, MD, PhD, Anne-Catherine Pouleur, MD, PhD, Bruno Guigas, PhD, Jean-Louis Vanoverschelde, MD, PhD, Joelle Kefer, MD, PhD, Luc Bertrand, PhD, Cécile Oury, PhD, Sandrine Horman, PhD, Christophe Beauloye, MD, PhD   +23 more
doaj   +2 more sources

Acetyl-CoA carboxylase maintains energetic balance for functional oogenesis [PDF]

Nature Communications
Reproduction is tightly linked to nutrient availability and metabolic homeostasis, yet how specific metabolic pathways coordinate with cellular signaling to control oogenesis remains unclear.
Oyundari Amartuvshin, Chi-Hung Lin, Yi-Ting Ke, Han-Jung Lee, Kreeti Kajal, Tsai-Ling Huang, Wen-Der Wang, Tsai-Ming Lu, Ling-Huei Yih, Chen-Yuan Tseng, Hwei-Jan Hsu   +10 more
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Chloroflexus aurantiacus acetyl-CoA carboxylase evolves fused biotin carboxylase and biotin carboxyl carrier protein to complete carboxylation activity [PDF]

mBio
Acetyl-CoA carboxylases (ACCs) convert acetyl-CoA to malonyl-CoA, a key step in fatty acid biosynthesis and autotrophic carbon fixation pathways. Three functionally distinct components, biotin carboxylase (BC), biotin carboxyl carrier protein (BCCP), and
Jiejie Shen, Wenping Wu, Kangle Wang, Jingyi Wu, Bing Liu, Chunyang Li, Zijun Gong, Xin Hong, Han Fang, Xingwei Zhang, Xiaoling Xu   +10 more
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Solution Structure and NMR Chemical Shift Perturbations of the Arabidopsis BCCP1 Identify Intersubunit Interactions Potentially Involved in the Assembly of the Heteromeric Acetyl‐CoA Carboxylase [PDF]

Plant Direct
Biotin carboxyl carrier protein (BCCP) is a subunit of the heteromeric acetyl‐CoA carboxylase (htACCase), and it chemically links the two half‐reactions that constitute the formation of malonyl‐CoA from acetyl‐CoA, a critical reaction in fatty acid ...
Kiran‐Kumar Shivaiah, Ganesh P. Subedi, Adam W. Barb, Basil J. Nikolau   +3 more
doaj   +2 more sources