Results 131 to 140 of about 42,990 (270)

Humanin Mitigates Aβ‐Induced Retinal Pigment Epithelium Injury via AMPK‐Beclin1‐Dependent Mitophagy

Aging Cell, Volume 25, Issue 7, July 2026.
Humanin (HN) enhanced the clearance of Aβ‐accumulated mitochondria in the RPE while preserving retinal function and RPE barrier integrity. HN activated AMP‐activated protein kinase (AMPK), leading to phosphorylation of ULK1 and Beclin1, which promoted the interaction between Beclin1 and Parkin and their translocation to mitochondria.
Ha Young Jang, Suyeon Choi, Soo‐Jin Kim, Sooyun Kim, Dong Hyun Jo, Tae Geol Lee, Kyu‐Sang Park, Jeong Hun Kim   +7 more
wiley   +1 more source

Acetyl-CoA carboxylase (ACCase)-inhibiting herbicides: Past, present, and future

Weed Technology
Acetyl-CoA carboxylase (ACCase)-inhibiting herbicides are primarily applied for controlling grass weeds in broadleaf crops. These herbicides are foliar-active, providing minimal residual weed control.
Amit J. Jhala, Mandeep Singh, Debalin Sarangi, Lovreet Shergill, Aniruddha Maity, Zahoor A. Ganie, Chandrima Shyam, Mithila Jugulam, Jason K. Norsworthy   +8 more
doaj   +1 more source

Targeting acetyl-CoA carboxylases for the treatment of MASLD

Journal of Lipid Research
Hepatic accumulation of triglycerides is a hallmark feature of metabolic dysfunction-associated steatotic liver disease (MASLD). Growing evidence indicates that increased rates of de novo lipogenesis (DNL) are one of the earliest metabolic changes promoting hepatic steatosis in the onset of MASLD.
María Antonia Mateo-Marín, Michele Alves-Bezerra   +1 more
openaire   +4 more sources

Comparative proteomics analysis of root and nodule mitochondria of soybean

Plant, Cell &Environment, Volume 49, Issue 7, Page 3482-3499, July 2026.
Abstract Legumes perform symbiotic nitrogen fixation through rhizobial bacteroids housed in specialised root nodules. The biochemical process is energy‐intensive and consumes a huge carbon source to generate sufficient reducing power. To maintain the symbiosis, malate is supplied by legume nodules to bacteroids as their major carbon and energy source ...
Wai‐Ching Sin, Jinhong Liu, Jia Yi Zhong, Hon‐Ming Lam, Boon Leong Lim   +4 more
wiley   +1 more source

Activation of hepatic acetyl-CoA carboxylase by glutamate and Mg2+ is mediated by protein phosphatase-2A.

, 1996
The activation of hepatic acetyl-CoA carboxylase by Na(+)-cotransported amino acids such as glutamine has been attributed mainly to the stimulation of its dephosphorylation by accumulating dicarboxylic acids, e.g. glutamate.
Hue, Louis, Gaussin, V., Stalmans, W., Bollen, M.   +3 more
core  

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, Volume 49, Issue 7, Page 3543-3559, July 2026.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source

Mechanism of activation of liver acetyl-CoA carboxylase by cell swelling.

, 1993
The activation of hepatic glycogen synthase by the amino-acid-induced cell swelling has been attributed to the stimulation of [glycogen-synthase]-phosphatase resulting from an increase in the intracellular content in glutamate and aspartate, and a ...
Hue, Louis, Gaussin, V., Stalmans, W., Baquet, A., Bollen, M.   +4 more
core   +1 more source

Cannabigerol Alleviates Obesity‐Induced Mitochondrial Dysfunction by Cardiolipin Fatty Acid Remodeling

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Graphical overview of the effects of the high‐fat, high‐sucrose (HFHS) diet regime and 2‐week cannabigerol (CBG) treatment on the intramuscular long‐chain fatty acids (LCFAs) trafficking and lipid metabolism, with subsequent implications for mitochondrial cardiolipin (CL) composition in the red gastrocnemius muscle.
Patrycja Bielawiec, Karolina Konstantynowicz‐Nowicka, Adrian Chabowski, Ewa Harasim‐Symbor   +3 more
wiley   +1 more source

The Three-Dimensional Structure of the Biotin Carboxylase-Biotin Carboxyl Carrier Protein Complex of E. coli Acetyl-CoA Carboxylase

, 2013
SummaryAcetyl-coenzyme A (acetyl-CoA) carboxylase is a biotin-dependent, multifunctional enzyme that catalyzes the regulated step in fatty acid synthesis.
Champion, Tyler S., Broussard, Tyler C, Champion, Tyler S, Kobe, Matthew J., Neau, David B., Waldrop, Grover L., Waldrop, Grover L, Pakhomova, Svetlana, Price, Amanda E., Kobe, Matthew J, Neau, David B, Broussard, Tyler C., Price, Amanda E   +12 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source