Results 21 to 30 of about 86,728 (368)

Increasing the Ascomycin Yield by Relieving the Inhibition of Acetyl/Propionyl-CoA Carboxylase by the Signal Transduction Protein GlnB

Frontiers in Microbiology, 2021
Ascomycin (FK520) is a multifunctional antibiotic produced by Streptomyces hygroscopicus var. ascomyceticus. In this study, we demonstrated that the inactivation of GlnB, a signal transduction protein belonging to the PII family, can increase the ...
Pan Wang, Pan Wang, Pan Wang, Xin Wang, Xin Wang, Xin Wang, Ying Yin, Ying Yin, Ying Yin, Mingliang He, Mingliang He, Mingliang He, Wei Tan, Wei Tan, Wei Tan, Wenting Gao, Wenting Gao, Wenting Gao, Jianping Wen, Jianping Wen, Jianping Wen   +20 more
doaj   +1 more source

Acetyl-CoA Carboxylases and Diseases

Frontiers in Oncology, 2022
Acetyl-CoA carboxylases (ACCs) are enzymes that catalyze the carboxylation of acetyl-CoA to produce malonyl-CoA. In mammals, ACC1 and ACC2 are two members of ACCs. ACC1 localizes in the cytosol and acts as the first and rate-limiting enzyme in the de novo fatty acid synthesis pathway.
Yu Wang, Weixing Yu, Sha Li, Dingyuan Guo, Jie He, Jie He, Yugang Wang, Yugang Wang   +7 more
openaire   +3 more sources

产油核桃内生细菌乙酰辅酶A羧化酶acb基因 克隆及优化表达Cloning and expression optimization of acetyl-CoA carboxylase acb gene from oil-producing walnut endophyte

Zhongguo youzhi, 2023
为了探究细菌异质性乙酰辅酶A羧化酶β亚基生物活性及其对乙酰辅酶A羧化酶酶活影响，以高产油核桃内生细菌B. subtilis HB1310基因组DNA为模板，利用PCR技术扩增其乙酰辅酶A羧化酶羧基转移酶β亚基（β-CT）基因（acb基因），构建pET-28a-acb载体并在E. coli BL21中表达，进一步对乙酰辅酶A羧化酶acb基因的诱导表达条件进行了优化。结果表明：乙酰辅酶A羧化酶acb基因在E.
许思远，张永贵，赵沛，曹娟娟，张琴XU Siyuan，ZHANG Yonggui，ZHAO Pei，CAO Juanjuan，ZHANG Qin
doaj   +1 more source

Expression of Yarrowia lipolytica acetyl-CoA carboxylase in Saccharomyces cerevisiae and its effect on in-vivo accumulation of Malonyl-CoA

Computational and Structural Biotechnology Journal, 2022
Malonyl-CoA is an energy-rich molecule formed by the ATP-dependent carboxylation of acetyl coenzyme A catalyzed by acetyl-CoA carboxylase. This molecule is an important precursor for many biotechnologically interesting compounds such as flavonoids ...
Humberto Pereira, Flávio Azevedo, Lucília Domingues, Björn Johansson   +3 more
doaj   +1 more source

GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH)

Expert Opinion on Investigational Drugs, 2020
Introduction: De novo lipogenesis (DNL) plays a major role in fatty acid metabolism and contributes significantly to triglyceride accumulation within the hepatocytes in patients with nonalcoholic steatohepatitis (NASH).
N. Alkhouri, E. Lawitz, M. Noureddin, R. DeFronzo, G. Shulman   +4 more
semanticscholar   +1 more source

OR24-5 Zebrafish in Utero Glucose Exposure Induces Lipid Dysregulation That Is Abrogated by Acetyl CoA Carboxylase or Glycolysis Inhibition [PDF]

J Endocr Soc, 2022
Carol Cox, Yann Gibert, Joshua S. Speed, Bridget Konadu   +3 more
europepmc   +3 more sources

Neonatal Vitamin C and Cysteine Deficiencies Program Adult Hepatic Glutathione and Specific Activities of Glucokinase, Phosphofructokinase, and Acetyl-CoA Carboxylase in Guinea Pigs’ Livers

Antioxidants, 2021
Premature neonates are submitted to an early-life oxidative stress from parenteral nutrition, which is vitamin C (VC) deficient and induces low endogenous levels of glutathione.
Vitor Teixeira, Ibrahim Mohamed, Jean-Claude Lavoie   +2 more
doaj   +1 more source

Hypothalamic inhibition of acetyl-CoA carboxylase stimulates hepatic counter-regulatory response independent of AMPK activation in rats. [PDF]

PLoS ONE, 2013
BACKGROUND: Hypothalamic AMPK acts as a cell energy sensor and can modulate food intake, glucose homeostasis, and fatty acid biosynthesis. Intrahypothalamic fatty acid injection is known to suppress liver glucose production, mainly by activation of ...
Gustavo A Santos, Vinícius D Pereira, Erika A F R Roman, Leticia Ignacio-Souza, Daniele C Vitorino, Rodrigo Ferreira de Moura, Daniela S Razolli, Adriana S Torsoni, Licio A Velloso, Marcio A Torsoni   +9 more
doaj   +1 more source

Regulation of acetyl-coA carboxylase: properties of coA activation of acetyl-coA carboxylase. [PDF]

Proceedings of the National Academy of Sciences, 1980
Acetyl-CoA carboxylase [acetyl-CoA:carbon-dioxide ligase (ADP-forming), EC 6.4.1.2] is activated by physiological concentrations of CoA. The CoA concentration dependency of this activation is sigmoidal; below 60 microM there is little or no activation, but the activation observed between 60 and 120 microM indicates that small changes in the ...
L A, Yeh, K H, Kim
openaire   +2 more sources

Arachidonate and medium-chain fatty acids inhibit transcription of the acetyl-CoA carboxylase gene in hepatocytes in culture

Journal of Lipid Research, 1997
Transcription of acetyl-CoA carboxylase in avian liver is low during starvation or after consumption of a low-carbohydrate, high-fat diet and high during consumption of a high-carbohydrate, low-fat diet.
F B Hillgartner, T Charron
doaj   +1 more source