Results 31 to 40 of about 56,101 (298)

Lactobacillus paracasei N1115 attenuates obesity in high‐fat diet‐induced obese mice

Food Science &Nutrition, Volume 11, Issue 1, Page 418-427, January 2023., 2023
Lactobacillus paracasei N1115 relieved high fat diet induced obesity. Lactobacillus paracasei N1115 decreased body weight, fat accumulation and hyperlipidemia by increasing the abundance of beneficial bacteria (Allobaculum and L. Zeae) and decreased harmful bacteria (Turicibacter).
Yanan Sun, Shanbin Chen, Fazheng Ren, Yixuan Li   +3 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Genes encoding plastid acetyl-CoA carboxylase and 3-phosphoglycerate kinase of the Triticum/Aegilops complex and the evolutionary history of polyploid wheat

Proceedings of the National Academy of Sciences of the United States of America, 2002
The classic wheat evolutionary history is one of adaptive radiation of the diploid Triticum/Aegilops species (A, S, D), genome convergence and divergence of the tetraploid (Triticum turgidum AABB, and Triticum timopheevii AAGG) and hexaploid (Triticum ...
Shaoxing Huang, A. Sirikhachornkit, X. Su, J. Faris, B. Gill, R. Haselkorn, P. Gornicki   +6 more
semanticscholar   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2017
Eukaryotic cells form stress granules under a variety of stresses, however the signaling pathways regulating their formation remain largely unknown. We have determined that the Saccharomyces cerevisiae lysine acetyltransferase complex NuA4 is required ...
Meaghen Rollins, Sylvain Huard, Alan Morettin, Jennifer Takuski, Trang Thuy Pham, Morgan D Fullerton, Jocelyn Côté, Kristin Baetz   +7 more
doaj   +1 more source

The Classical, Yet Controversial, First Enzyme of Lipid Synthesis: Escherichia coli Acetyl-CoA Carboxylase

Microbiology and Molecular Biology Reviews, 2021
Escherichia coli acetyl-CoA carboxylase (ACC), the enzyme responsible for synthesis of the malonyl-CoA, the building block of fatty acid synthesis, is the paradigm bacterial ACC.
J. Cronan
semanticscholar   +1 more source

Enhancement of docosahexaenoic acid production by overexpression of ATP-citrate lyase and acetyl-CoA carboxylase in Schizochytrium sp.

Biotechnology for Biofuels, 2020
Docosahexaenoic acid (DHA) is an important omega-3 long-chain polyunsaturated fatty acid that has a variety of physiological functions for infant development and human health.
Xiao Han, Zhunan Zhao, Y. Wen, Zhi Chen
semanticscholar   +1 more source

Acetyl‐CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents

Hepatology, 2018
Pharmacologic inhibition of acetyl‐CoA carboxylase (ACC) enzymes, ACC1 and ACC2, offers an attractive therapeutic strategy for nonalcoholic fatty liver disease (NAFLD) through simultaneous inhibition of fatty acid synthesis and stimulation of fatty acid ...
L. Goedeke, J. Bates, D. Vatner, R. Perry, Ting Wang, Ricardo Ramírez, Li Li, Matthew W. Ellis, Dongyan Zhang, Kari E. Wong, C. Beysen, G. Cline, A. Ray, G. Shulman   +13 more
semanticscholar   +1 more source

The subcellular localization of acetyl-CoA carboxylase 2 [PDF]

Proceedings of the National Academy of Sciences, 2000
Animals, including humans, express two isoforms of acetyl-CoA carboxylase (EC 6.4.1.2 ), ACC1 ( M r = 265 kDa) and ACC2 ( M r = 280 kDa). The predicted amino acid sequence of ACC2 contains an additional 136 aa relative to ACC1, 114 of which ...
Lutfi Abu-Elheiga, William R. Brinkley, Ling Zhong, Subrahmanyam S. Chirala, Gebretateos Woldegiorgis, Salih J. Wakil   +5 more
openalex   +4 more sources

Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses. [PDF]

PLoS ONE, 2015
Differentiation of T cells is closely associated with dynamic changes in nutrient and energy metabolism. However, the extent to which specific metabolic pathways and molecular components are determinative of CD8+ T cell fate remains unclear.
Jang Eun Lee, Matthew C Walsh, Kyle L Hoehn, David E James, E John Wherry, Yongwon Choi   +5 more
doaj   +1 more source