Results 31 to 40 of about 82,191 (356)
Frontiers in Microbiology, 2018 Malonyl-coenzyme A (malonyl-CoA) is a critical precursor for the biosynthesis of a variety of biochemicals. It is synthesized by the catalysis of acetyl-CoA carboxylase (Acc1p), which was demonstrated to be deactivated by the phosphorylation of Snf1 ...
Xiaoxu Chen +5 more
doaj +2 more sources
Expression of genes encoding acetyl-CoA carboxylase, biotin synthase, and acetyl-CoA generating enzymes in Arabidopsis thaliana [PDF]
, 1997 Acetyl-CoA carboxylase catalyzes the formation of malonyl-CoA from acetyl-CoA. The four genes encoding heteromeric acetyl-CoA carboxylase are coordinately expressed in leaves, flowers, and developing siliques and embryos. The highest expression occurs in
Jinshan Ke
openalex +4 more sources
Hepatology, EarlyView., 2022 Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim +12 more
wiley +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Purification and characterisation of an insulin-stimulated protein-serine kinase which phosphorylates acetyl-CoA carboxylase [PDF]
, 1998 An insulin-stimulated protein kinase specific for acetyl-CoA carboxylase has been purified from rat epididymal adipose tissue using Mono-Q chromatography.
Denton, R.M, Heesom, K.J, Moule, S.K
core +1 more source
Avidin as a probe of the conformational changes induced in pyruvate carboxylase by acetyl-CoA and pyruvate [PDF]
, 1986 Sheep liver pyruvate carboxylase was mixed with avidin at a molar ratio of 1:1 in the presence of various combinations of the components of the assay systems required for either the acetyl-CoA-dependent or the acetyl-CoA-independent activity and ...
Attwood, Paul V. +2 more
core +1 more source
Biotechnology for Biofuels, 2020 Docosahexaenoic acid (DHA) is an important omega-3 long-chain polyunsaturated fatty acid that has a variety of physiological functions for infant development and human health.
Xiao Han, Zhunan Zhao, Y. Wen, Zhi Chen
semanticscholar +1 more source
The Distinctive Regulatory Mechanisms of Bacterial Acetyl-CoA Carboxylase [PDF]
, 2018 Metabolic Regulation is a complex system used to control cellular metabolism in response to conditions in the cell’s environment. For most enzymes, the cell can rely upon a minimal amount of regulation; however, critical enzymes, such as acetyl-CoA ...
Evans, Alexandra Leigh
core +2 more sources
Hepatology, 2018 Pharmacologic inhibition of acetyl‐CoA carboxylase (ACC) enzymes, ACC1 and ACC2, offers an attractive therapeutic strategy for nonalcoholic fatty liver disease (NAFLD) through simultaneous inhibition of fatty acid synthesis and stimulation of fatty acid ...
L. Goedeke +13 more
semanticscholar +1 more source
Microbiology and Molecular Biology Reviews, 2021 Escherichia coli acetyl-CoA carboxylase (ACC), the enzyme responsible for synthesis of the malonyl-CoA, the building block of fatty acid synthesis, is the paradigm bacterial ACC.
J. Cronan
semanticscholar +1 more source