Results 11 to 20 of about 28,974 (220)

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. [PDF]

Cancer Cell, 2015
A functional genomics study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions. Comparative metabolomics and lipidomics demonstrated that acetate is used as a nutritional source by cancer cells in an ACSS2-dependent manner, and supplied a significant fraction of
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K, McGarry L, James D, Shanks E, Kalna G, Saunders RE, Jiang M, Howell M, Lassailly F, Thin MZ, Spencer-Dene B, Stamp G, van den Broek NJ, Mackay G, Bulusu V, Kamphorst JJ, Tardito S, Strachan D, Harris AL, Aboagye EO, Critchlow SE, Wakelam MJ, Schulze A, Gottlieb E.   +32 more
europepmc   +4 more sources

Fasting-Induced Hypothermia and Reduced Energy Production in Mice Lacking Acetyl-CoA Synthetase 2 [PDF]

Cell Metabolism, 2009
Acetate is activated to acetyl-CoA by acetyl-CoA synthetase 2 (AceCS2), a mitochondrial enzyme. Here, we report that the activation of acetate by AceCS2 has a specific and unique role in thermogenesis during fasting. In the skeletal muscle of fasted AceCS2(-/-) mice, ATP levels were reduced by 50% compared to AceCS2(+/+) mice.
Sakakibara, Iori, Fujino, Takahiro, Ishii, Makoto, Tanaka, Toshiya, Shimosawa, Tatsuo, Miura, Shinji, Zhang, Wei, Tokutake, Yuka, Yamamoto, Joji, Awano, Mutsumi, Iwasaki, Satoshi, Motoike, Toshiyuki, Okamura, Masashi, Inagaki, Takeshi, Kita, Kiyoshi, Ezaki, Osamu, Naito, Makoto, Kuwaki, Tomoyuki, Chohnan, Shigeru, Yamamoto, Tokuo T., Hammer, Robert E., Kodama, Tatsuhiko, Yanagisawa, Masashi, Sakai, Juro   +23 more
openaire   +3 more sources

Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway. [PDF]

Acta Pharmacol Sin, 2023
Diabetic nephropathy (DN) is characterized by chronic low-grade renal inflammatory responses, which greatly contribute to disease progression. Abnormal glucose metabolism disrupts renal lipid metabolism, leading to lipid accumulation, nephrotoxicity, and subsequent aseptic renal interstitial inflammation.
Lu J, Li XQ, Chen PP, Zhang JX, Li L, Wang GH, Liu XQ, Jiang CM, Ma KL.   +8 more
europepmc   +3 more sources

A Computational Approach for Designing a Peptide-Based Acetyl-CoA Synthetase 2 Inhibitor: A New Horizon for Anticancer Development. [PDF]

Cell Biochem Biophys
Abstract Acetyl-CoA Synthetase 2 (ACSS2) has emerged as a new target for anticancer development owing to its high expression in various tumours and its enhancement of malignancy. Stressing the growing interest in peptide-derived drugs featuring better selectivity and efficacy, a computational protocol was applied to design a peptide inhibitor
Ali M, Oduro-Kwateng E, Kehinde IO, Parinandi NL, Soliman MES.   +4 more
europepmc   +4 more sources

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

Antioxidants, 2021
Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan extending calorie restriction (CR) decreases glucose-derived metabolic flux
Patrick C. Bradshaw
doaj   +3 more sources

Acetyl-CoA synthetase 2 alleviates brain injury following cardiac arrest by promoting autophagy in brain microvascular endothelial cells. [PDF]

Cell Mol Life Sci
Brain injury is a common sequela following cardiac arrest (CA), with up to 70% of hospitalized patients dying from it. Brain microvascular endothelial cells (BMVECs) play a crucial role in post-cardiac arrest brain injury (PCABI). However, the effects and mechanisms of targeting BMVEC energy metabolism to mitigate brain injury remain unclear.We ...
Zhang W, Yu X, Lin Y, Wu C, Zhu R, Jiang X, Tao J, Chen Z, He J, Zhang X, Xu J, Zhang M.   +11 more
europepmc   +3 more sources

ACSS2 governs milk fat synthesis in buffalo via a reciprocal positive feedback loop with SREBP1 and PPARG [PDF]

Animal Bioscience
Objective Acetyl-CoA synthetase 2 (ACSS2) converts rumen-derived acetate into acetyl-CoA in ruminants. Whether it actively regulates lactation-associated transcriptional networks beyond its catalytic role remains unclear. This study aimed to characterize
Lige Huang, Rongping Wang, Fangting Zhou, Ruixia Gao, Xinyang Fan, Yongwang Miao   +5 more
doaj   +2 more sources

Post-crotonylation oxidation by a monooxygenase promotes acetyl-CoA synthetase degradation in Streptomyces roseosporus

Communications Biology, 2023
Protein post-translational modifications (PTMs) with various acyl groups play central roles in Streptomyces. But whether these acyl groups can be further modified, and the influences of these potential modifications on bacterial physiology have not been ...
Bing-Bing Ma, Chen-Fan Sun, Jing-Yi Zhou, Shuai-Lei Gu, Xin-Yi Dai, Yan-Zhen Chen, Qing-Wei Zhao, Xu-Ming Mao   +7 more
doaj   +2 more sources

Acetyl-coenzyme A synthetase 2-mediated acetyl-coenzyme A accumulation promotes mitophagy and tumor growth via increased H3K27ac in hepatitis B virus-related hepatocellular carcinoma [PDF]

Clinical and Molecular Hepatology
Background/Aims Acetyl coenzyme A (acetyl-CoA) is one of the most essential metabolites in cell metabolism but its function and concentration in hepatocellular carcinoma (HCC) remain elusive and controversial.
Shan Li, Jie Hu, Yihan Yan, Xinrui Liu, Xiao Dong, Huijun Liang, Xin Tang, Junji Tao, Rong Zhang, Yuan Hu, Ailong Huang, Kai Wang, Ni Tang   +12 more
doaj   +2 more sources

Functions of the prp operon in carbon source metabolism and acetic acid resistance in acetic acid bacteria: a case study in Acetobacter pasteurianus CGMCC 1.41 [PDF]

BMC Microbiology
Background prp operon usually comprises prpB, prpC, prpD and prpE genes, encoding 2-methylisocitrate (2-MIC) lyase, 2-methylcitrate (2-MC) synthase, 2-MC dehydratase and propionyl-CoA synthetase, respectively, which constitute the pathway 2-methylcitrate
Haoran Yang, Armin Ehrenreich, Wolfgang Liebl, Fusheng Chen   +3 more
doaj   +2 more sources