Results 21 to 30 of about 28,974 (220)

Acetyl-CoA Synthetase 2 Promotes Cell Migration and Invasion of Renal Cell Carcinoma by Upregulating Lysosomal-Associated Membrane Protein 1 Expression

Cellular Physiology and Biochemistry, 2018
Background/Aims: Reprogramming energy metabolism is an emerging hallmark of many cancers, and this alteration is especially evident in renal cell carcinomas (RCCs). However, few studies have been conducted on lipid metabolism. This study investigated the
Lv Yao, Xiaoqiang Guo, Yaoting Gui
doaj   +4 more sources

Plasmodium falciparum Acetyl-CoA Synthetase Is Essential for Parasite Intraerythrocytic Development and Chromatin Modification

, 2021
The malaria parasite Plasmodium falciparum possesses a unique Acetyl-CoA Synthetase (PfACS), which provides acetyl moieties for different metabolic and regulatory cellular pathways.
Eliana Fernanda Galindo Cubillos (11689104), Joaquim Martins (7362692), Gerhard Wunderlich (87826), João Carlos Setubal (11689110), Isadora Oliveira Prata (11689101), Arne Krüger (11689107), Deibs Barbosa (406609)   +6 more
core   +4 more sources

D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase

Cell Reports, 2023
Summary: The generation of neurons from quiescent radial-glia-like neural stem cells (RGLs) in adult brain goes hand in hand with the modulation of cellular metabolism.
Yinghao Liu, Min Wang, Ye Guo, Lei Wang, Weixiang Guo   +4 more
doaj   +1 more source

Acetyl-CoA Synthetase 2, a Mitochondrial Matrix Enzyme Involved in the Oxidation of Acetate [PDF]

Journal of Biological Chemistry, 2001
Using peptide sequences derived from bovine cardiac acetyl-CoA synthetase (AceCS), we isolated and characterized cDNAs for a bovine and murine cardiac enzyme designated AceCS2. We also isolated a murine cDNA encoding a hepatic type enzyme, designated AceCS1, identical to one reported recently (Luong, A., Hannah, V. C., Brown, M. S., and Goldstein, J. L.
T, Fujino, J, Kondo, M, Ishikawa, K, Morikawa, T T, Yamamoto   +4 more
openaire   +2 more sources

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2 [PDF]

Proceedings of the National Academy of Sciences, 2006
We report that human acetyl-CoA synthetase 2 (AceCS2) is a mitochondrial matrix protein. AceCS2 is reversibly acetylated at Lys-642 in the active site of the enzyme. The mitochondrial sirtuin SIRT3 interacts with AceCS2 and deacetylates Lys-642 both in vitro and in vivo .
Schwer, Bjørn, Bunkenborg, Jakob, Verdin, Regis O., Andersen, Jens S., Verdin, Eric   +4 more
openaire   +3 more sources

ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

Molecular Neurodegeneration, 2023
Background Nuclear acetyl-CoA pools govern histone acetylation that controls synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer’s disease (AD).
Yingbin Lin, Anlan Lin, Lili Cai, Weibin Huang, Shanzhi Yan, Yuanxiang Wei, Xinglin Ruan, Wenting Fang, Xiaoman Dai, Jinbo Cheng, Jie Zhang, Wanjin Chen, Qinyong Ye, Xiaochun Chen, Jing Zhang   +14 more
doaj   +1 more source

Genetic Interaction Analysis Reveals that Cryptococcus neoformans Utilizes Multiple Acetyl-CoA-Generating Pathways during Infection

mBio, 2022
Cryptococcus neoformans is an important human fungal pathogen for which the external environment is its primary niche. Previous work has shown that two nonessential acetyl-CoA metabolism enzymes, ATP-citrate lyase (ACL1) and acetyl-CoA synthetase (ACS1),
Katy M. Alden, Andrew J. Jezewski, Sarah R. Beattie, David Fox, Damian J. Krysan   +4 more
doaj   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4‐Fatty Acid β‐Oxidation Pathway

Advanced Science, 2022
Metabolic reprogramming is often observed in carcinogenesis, but little is known about the aberrant metabolic genes involved in the tumorigenicity and maintenance of stemness in cancer cells. Sixty‐seven oncogenic metabolism‐related genes in liver cancer
Hongquan Li, Junjiao Song, Yifei He, Yizhe Liu, Zhen Liu, Weili Sun, Weiguo Hu, Qun‐Ying Lei, Xin Hu, Zhiao Chen, Xianghuo He   +10 more
doaj   +1 more source

Mechanisms by which tumor necrosis factor stimulates hepatic fatty acid synthesis in vivo

Journal of Lipid Research, 1988
We have previously shown that bolus intravenous administration of tumor necrosis factor (TNF) to normal rats results in a rapid (within 90 min) stimulation of hepatic fatty acid synthesis, which is sustained for 17 hr.
C Grunfeld, J A Verdier, R Neese, A H Moser, K R Feingold   +4 more
doaj   +1 more source