Results 31 to 40 of about 28,974 (220)

The Roles of Coenzyme A Binding Pocket Residues in Short and Medium Chain Acyl-CoA Synthetases

Life, 2023
Short- and medium-chain acyl-CoA synthetases catalyze similar two-step reactions in which acyl substrate and ATP bind to form an enzyme-bound acyl-adenylate, then CoA binds for formation of the acyl-CoA product.
Yu Meng, Cheryl Ingram-Smith, Oly Ahmed, Kerry Smith   +3 more
doaj   +1 more source

Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress [PDF]

Cancer & Metabolism, 2014
During tumour formation and expansion, cancer cells encounter constantly changing environmental conditions in which nutrient and oxygen availability may be severely compromised. The metabolic transformation of cancer cells is characterised by distinct changes in metabolic activity that satisfy the exigencies of energy and biomass production imposed by ...
Schug, Zachary, Peck, Barrie, Jones, Dylan, Zhang, Qifeng, Alam, Israt, Witney, Tim, Smethurst, Elizabeth, Grosskurth, Shaun, Harris, Adrian, Critchlow, Susan, Aboagye, Eric, Wakelam, Michael, Schulze, Almut, Gottlieb, Eyal   +13 more
openaire   +1 more source

The role of nuclear receptor NHR-64 in fat storage regulation in Caenorhabditis elegans. [PDF]

PLoS ONE, 2010
Nuclear hormone receptors (NHRs) play vital roles in the regulation of metabolism, reproduction, and development. We found that inactivation of a C.
Bin Liang, Kim Ferguson, Lisa Kadyk, Jennifer L Watts   +3 more
doaj   +1 more source

Predicted role of Acetyl-CoA synthetase and HAT p300 in extracellular lactate mediated lactylation in the tumor: In vitro and in silico models

, 2023
Background As per the Warburg effect, cancer cells are known to convert pyruvate into lactate. The accumulation of lactate is associated with metabolic and epigenetic reprogramming, which has newly been suggested to involve lactylation. However, the role
Rushikesh, Patel, Jayanta K., pal, Mrudula , Joshi, Ajay, Kumar, Kiran Bharat, Lokhande, Prof. Nilesh Kumar, Sharma, Kratika , Khunteta   +6 more
core   +1 more source

Functional Characteristics of Aldehyde Dehydrogenase and Its Involvement in Aromatic Volatile Biosynthesis in Postharvest Banana Ripening

Foods, 2022
Butanol vapor feeding to ripe banana pulp slices produced abundant butyl butanoate, indicating that a portion of butanol molecules was converted to butanoate/butanoyl-CoA via butanal, and further biosynthesized to ester. A similar phenomenon was observed
Yoshinori Ueda, Wei Zhao, Hideshi Ihara, Yoshihiro Imahori, Eleni Tsantili, Sumithra K. Wendakoon, Alan Chambers, Jinhe Bai   +7 more
doaj   +1 more source

Regulated Acyl-CoA Synthetase Short-Chain Family Member 2 Accumulation During Spermatogenesis [PDF]

Cell Journal, 2019
Objective Acyl-CoA synthetase short-chain family member 2 (ACSS2) activity provides a major source of acetyl-CoA to drive histone acetylation. This study aimed to unravel the ACSS2 expression during mouse spermatogenesis, where a dynamic and stage ...
Afsaneh Goudarzi, Amir Amiri-Yekta
doaj   +1 more source

Molecular basis and functional characterization of human 3-methylcrotonyl-CoA carboxylase deficiency [PDF]

, 2009
3-Methylcrotonyl-CoA carboxylase (MCC) deficiency is a rare disorder of leucine catabolism inherited as an autosomal recessive trait. The phenotypic expression of the disease is highly variable, ranging from neonatal onset with severe neurological ...
Dantas, Maria Fernanda
core   +1 more source

Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis—Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases

Frontiers in Physiology, 2020
Acetate is a major end product of bacterial fermentation of fiber in the gut. Acetate, whether derived from the diet or from fermentation in the colon, has been implicated in a range of health benefits.
John R. Moffett, Narayanan Puthillathu, Ranjini Vengilote, Diane M. Jaworski, Aryan M. Namboodiri   +4 more
doaj   +1 more source

Plasmodium falciparum Acetyl-CoA Synthetase Is Essential for Parasite Intraerythrocytic Development and Chromatin Modification

, 2021
The malaria parasite Plasmodium falciparum possesses a unique Acetyl-CoA Synthetase (PfACS), which provides acetyl moieties for different metabolic and regulatory cellular pathways.
Isadora Oliveira Prata (11689101), Gerhard Wunderlich, Eliana Fernanda Galindo Cubillos, Joaquim Martins, João Carlos Setubal, Isadora Oliveira Prata, Deibs Barbosa, Arne Krüger (11689107), Deibs Barbosa (406609), Eliana Fernanda Galindo Cubillos (11689104), Joaquim Martins (7362692), Arne Krüger, Gerhard Wunderlich (87826), João Carlos Setubal (11689110)   +13 more
core   +1 more source

Acetyl-CoA Synthetase 2 Confers a Growth Advantage under Metabolic Stress [PDF]

Cancer Discovery, 2015
Abstract ACSS2 upregulation under metabolic stress enhances acetate usage and supports cancer cell survival.
openaire   +1 more source