Results 71 to 80 of about 28,974 (220)

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke

Frontiers in Pharmacology, 2019
Cerebral energy deficiency is a key pathophysiologic cascade that results in neuronal injury and necrosis after ischemic stroke. Shengui Sansheng San (SSS) has been used to treat stroke for more than 300 years.
Cheng Luo, Xiqing Bian, Qian Zhang, Zhenyan Xia, Bowen Liu, Qi Chen, Chienchih Ke, Chienchih Ke, Jian-Lin Wu, Yonghua Zhao   +9 more
doaj   +1 more source

Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source

Dietary α-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells

Journal of Lipid Research, 2004
Fatty acid synthetase (FAS) is overexpressed in various tumor tissues, and its inhibition and/or malonyl-CoA accumulation have been correlated to apoptosis of tumor cells.
A. Vecchini, V. Ceccarelli, F. Susta, P. Caligiana, P. Orvietani, L. Binaglia, G. Nocentini, C. Riccardi, G. Calviello, P. Palozza, N. Maggiano, P. Di Nardo   +11 more
doaj   +1 more source

Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR‐TKIs

Journal of Clinical Laboratory Analysis, EarlyView.
Cancer metabolism has emerged as a critical area of study in cancer research, offering insights into the complex mechanisms underlying tumor growth and development. Lipid metabolic reprogramming, especially the dynamic balance between fatty acid synthesis and fatty acid oxidation, plays significant roles in tumor progression. ABSTRACT Background Cancer
Wenhao Luo, Zun Wang, Guangzhi Ma, Wang Shen, Xiaobo Chen, Yida Liao   +5 more
wiley   +1 more source

Response to letter-to-the-editor: “Acetyl-CoA synthetase (ACSS2) does not generate butyryl- and crotonyl-CoA”

International audienceResponse to letter-to-the-editor: "Acetyl-CoA synthetase (ACSS2) does not generate butyryl-and crotonyl-CoA" Dear Editors of Molecular Metabolism, Thank you for the opportunity to respond to the Letter-to-the-Editor regarding our ...
Schlattner, Uwe, Uwe Schlattner, Saadi Khochbin, Petosa, Carlo, Carlo Petosa, Khochbin, Saadi   +5 more
core   +1 more source

Engineering of acetyl-CoA metabolism for the improved production of polyhydroxybutyrate in Saccharomyces cerevisiae

, 2012
Through metabolic engineering microorganisms can be engineered to produce new products and further produce these with higher yield and productivities.
Jens Nielsen, Kocharin, Kanokarn, Yun Chen, Nielsen, Jens B, Siewers, Verena,, Siewers, Verena, Kocharin, Kanokarn,, Chen, Yun,, Kanokarn Kocharin, Verena Siewers, Chen, Yun, Nielsen, Jens B,, Nielsen, Jens B.   +12 more
core   +1 more source

Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis (PD) is a chronic inflammatory disease with systemic effects. Emerging evidence suggests a link between periodontal inflammation and neurological changes, but the biochemical mechanisms in key brain regions, such as the hippocampus and amygdala, remain unclear.
Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz e Magalhães, Elizabeth Luciana Marinho Miguel, Larissa Vieira Toledo, Débora Ribeiro Orlando, Alan Rodrigues Teixeira Machado, Bruno Del Bianco Borges, Luciano José Pereira, Marco Fabrício Dias‐Peixoto, Eric Francelino Andrade   +9 more
wiley   +1 more source

ADP-dependent Phosphofructokinases in Mesophilic and Thermophilic Methanogenic Archaea

, 2001
Phosphofructokinase (PFK) is a key enzyme of the glycolytic pathway in all domains of life. Two related PFKs, ATP-dependent and PPi-dependent PFK, have been distinguished in bacteria and eucarya, as well as in some archaea.
Kengen, S.W.M., Vos, W.M., de, Verhees, C.H., Tuininga, J.E., van der Oost, J., Stams, A.J.M., Oost, J., van der, de Vos, W.M.   +7 more
core   +1 more source

LKB1 Loss Sensitizes Lung Tumor Spheres to Mitomet‐Induced Ferroptosis, and These Effects are Enhanced by mTOR Inhibition

Molecular Carcinogenesis, EarlyView.
ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang, Ali Nakhi, Peter I. Dosa, Gunda I. Georg, Fekadu Kassie   +4 more
wiley   +1 more source

Molecular regulation of the cardiac-enriched acetyl-CoA carboxylase isoform (ACCβ) : a novel target for therapeutic interventions in cardiovascular disease

, 2006
Includes bibliographical references (leaves 130-173).Metabolic remodeling is thought to be an important contributor towards the development of various cardiac pathophysiologic conditions.
Makaula, Siyanda S S
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