Results 91 to 100 of about 25,053 (234)

Phenoxodiol protects against Cisplatin induced neurite toxicity in a PC-12 cell model [PDF]

, 2007
BACKGROUND: Many commonly used chemotherapeutic agents, such as Cisplatin, are restricted in their potential anti-neoplastic effectiveness by their side effects, with one of the most problematic being induction of peripheral neuropathy. Although a number
Reuben Klein, David Brown, Ann M Turnley
core   +2 more sources

Energetic stress in combination with impaired fatty acid oxidation induces sequestration of CoA and adaptation of CoA metabolism

The FEBS Journal, EarlyView.
Computational modelling and in vitro liver cell experiments indicate that medium‐chain acyl‐CoA dehydrogenase (MCAD) deficiency causes an accumulation of (especially medium‐chain) acyl‐CoAs at the cost of free CoA (CoASH). A substantial decrease in CoASH impairs flux through many pathways essential for energy homeostasis.
Ligia Akemi Kiyuna, Christoff Odendaal, Madhulika Singh, Albert Gerding, Miriam Langelaar‐Makkinje, Marianne van der Zwaag, Asmara Drachman, Vladimíra Cetkovská, Gaby Liem Foeng Kioen, Anne‐Claire M. F. Martines, Nicolette C. A. Huijkman, Hein Schepers, Bart van de Sluis, Dirk‐Jan Reijngoud, Ody C. M. Sibon, Amy C. Harms, Thomas Hankemeier, Barbara M. Bakker   +17 more
wiley   +1 more source

Impact of pretreatment with carnitine and tadalafil on contrast-induced nephropathy in CKD patients

Renal Failure, 2019
Objective: The present study assesses whether phosphodiesterase type 5 (PDE-5) inhibitor or carnitine exert nephroprotective effects against clinical contrast-induced nephropathy (CIN).
Zaher Armaly, Suheil Artol, Adel R. Jabbour, Amer Saffouri, Nayef Habashi, Amir Abd Elkadir, Naser Ghattas, Raymond Farah, Safa Kinaneh, William Nseir   +9 more
doaj   +1 more source

Hypothesis: is yeast a clock model to study the onset of humans aging phenotypes? [PDF]

, 2012
In this paper we report the growth and aging of yeast colonies derived from single cells isolated by micromanipulation and seeded one by one on separated plates to avoid growth interference by surrounding colonies.
Falcone, Claudio, Mangiapelo, Eleonora, Mazzoni, Cristina, Palermo, Vanessa   +3 more
core   +3 more sources

Intermittent hypoxia increases lipid insulin resistance in healthy humans: A randomized crossover trial

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
This scheme illustrates the main results of the present study showing an increase in circulating free fatty acids (FFA) that are likely to be related to several mechanisms like decrease in FFA insulin sensitivity and increase in FFA production. Significant changes are labelled in white, and non‐significant or hypothesis are labelled in pale green ...
Anne Briançon‐Marjollet, Marie Netchitaïlo, Fanny Fabre, Elise Belaidi, Claire Arnaud, Anne‐Laure Borel, Patrick Levy, Jean‐Louis Pépin, Renaud Tamisier   +8 more
wiley   +1 more source

Comparing methods to combine functional loss and mortality in clinical trials for amyotrophic lateral sclerosis [PDF]

, 2018
Objective: Amyotrophic lateral sclerosis (ALS) clinical trials based on single end points only partially capture the full treatment effect when both function and mortality are affected, and may falsely dismiss efficacious drugs as futile.
Berg, L.H. (Leonard) van den, Eijkemans, M.J.C. (Marinus J. C.), Nikolakopoulos, S. (Stavros), Rizopoulos, D. (Dimitris), Van Eijk, R.P.A. (Ruben P.A.)   +4 more
core   +4 more sources

Mitochondrial respiration and hydrogen peroxide production rate in right atrial tissues from obese diabetic patients

Experimental Physiology, EarlyView.
Abstract Type 2 diabetes (T2D) is a global epidemic, with heart failure being the leading cause of premature death. Mitochondrial dysfunction, characterized by impaired energy metabolism, weakened energy transport system and increased oxidative stress, has been proposed as a key contributor to the impairment of contractile function in T2D hearts ...
Toan Pham, Sarbjot Kaur, Anthony Hickey, Marie‐Louise Ward, Kenneth Tran   +4 more
wiley   +1 more source

Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock: The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial [PDF]

, 2018
Importance: Sepsis induces profound metabolic derangements, while exogenous levocarnitine mitigates metabolic dysfunction by enhancing glucose and lactate oxidation and increasing fatty acid shuttling.
Adams, Jason Y., Arnold, Ryan, Courtney, D. Mark, Guirgis, Faheem W., Jones, Alan E., Kline, Jeffrey A., Kurz, Michael C., Nandi, Utsav, Patki, Deepti, Puskarich, Michael A., Roberts, Brian W., Runyon, Michael, Shapiro, Nathan I., Sherwin, Robert, Sterling, Sarah A., Trzeciak, Stephen, Viele, Kert, Wang, Henry E.   +17 more
core   +1 more source

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Update on critical evidence for use of carnitine analogs in clinical practice in CNS disorders

Nutrition and Dietary Supplements, 2011
Giovanna TrainaDepartment of Economics and Food Sciences, University of Perugia, Perugia, ItalyAbstract: L-carnitine (LC) is part of the carnitine shuttle system at the mitochondrial inner membrane (MIM) and transports long chain fatty acids over the MIM
Traina G
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