Results 151 to 160 of about 25,053 (234)

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics, Volume 3, Issue 1, March 2026.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
wiley   +1 more source

Urinary excretion of L-carnitine, acetyl-L-carnitine, propionyl-L-carnitine and their antioxidant activities after single dose administration of L-carnitine in healthy subjects

Brazilian Journal of Pharmaceutical Sciences, 2013
The urine excretion of L-carnitine (LC), acetyl-L-carnitine (ALC) and propionyl-Lcarnitine (PLC) and their relations with the antioxidant activities are presently unknown.
Yu Cao, Chuan-ji Hao, Chen-jing Wang, Peng-li Li, Le-xin Wang, Hua-shi Guan, Huan-ting Li   +6 more
doaj  

Neuroprotective effects of carnitinoid compounds in rodent cellular and in vivo models of mitochondrial complex I dysfunction [PDF]

, 2019
Rotenone-mediated mitochondrial complex I inhibition was used to model Parkinson’s disease-like syndrome in Lewis rats. Tyrosine hydroxylase immunolabeling demonstrated a decrease in the number of dopaminergic neurons as well as aberrant morphology in ...
Steliou, Kosta
core  

Uptake of Prochlorococcus‐derived metabolites by Alteromonas macleodii MIT1002 shows high levels of substrate specificity

Limnology and Oceanography Letters, Volume 11, Issue 2, March 2026.
Abstract Seawater contains small biomolecules, or metabolites, that are highly labile components of dissolved organic matter (DOM). Marine microbes interact by exchanging metabolites, thus shaping marine microbial ecology, DOM composition, and global carbon cycling.
Kathryn H. Halloran, Rogier Braakman, Allison Coe, Gretchen Swarr, Melissa C. Kido Soule, Sallie W. Chisholm, Elizabeth B. Kujawinski   +6 more
wiley   +1 more source

Development and Application of a UPLC–MRM–MS Method for Quantifying Trimethylamine, Trimethylamine-N-Oxide, and Related Metabolites in Individuals with and Without Metabolic Syndrome

Separations
Trimethylamine-N-oxide (TMAO) is associated with various chronic diseases. TMAO is a downstream oxidative metabolite of trimethylamine (TMA) that is generated by the gut microbiota from dietary choline, carnitine, and betaine.
Mohammed E. Hefni, Cornelia M. Witthöft
doaj   +1 more source

Clinical Evidence of Acetyl-L-Carnitine Efficacy in the Treatment of Acute Ischemic Stroke: A Pilot Clinical Trial. [PDF]

Oxid Med Cell Longev, 2022
Mazdeh M, Abolfathi P, Sabetghadam M, Mohammadi Y, Mehrpooya M.   +4 more
europepmc   +1 more source

Trans‐Omics Integration Reveals That the Kidney Contributes to Systemic Aging via Sexually Dimorphic Accumulation of Glycosphingolipids

MedComm, Volume 7, Issue 3, March 2026.
Female‐specific renal GluCer accumulation disrupts mitochondrial quality control via a conserved purine‐mTORC1 pathway, triggering a wave of uremic toxins into the systemic circulation that constitutes a female‐biased vulnerability toward renal‐driven multiorgan senescence.
Zhen Ni, Chenyin Cao, Yanlin Tian, Jinming Mu, He Tian, Zehua Wang, Shaohua Zhang, Mingjun Cao, Yuntian Yang, Wei Ling Florence Lim, Jingkang Cui, Huan Sun, Huan Miao, Yuan Wang, Jie Du, Timothy Kwok, Huan Chen, Sin Man Lam, Guanghou Shui   +18 more
wiley   +1 more source

Discovery and validation of acetyl-L-carnitine in serum for diagnosis of major depressive disorder and remission status through metabolomic approach. [PDF]

Front Psychiatry, 2022
Lee S, Mun S, Lee YR, Choi H, Joo EJ, Kang HG, Lee J.   +6 more
europepmc   +1 more source

Mitochondrial function and acetyl-L-carnitine neuroprotection

, 2010
Mitochondrial dysfunction is involved in a number of chronic neurodegenerative disorders. Acetyl-L-carnitine (ALC) has been proposed to confer effective neuroprotection by increasing mitochondria viability, but little is known regarding the molecular mechanisms involved in its ...
Cunha, Lídia, Bravo, Joana, Gonçalves, Raquel, Metello, Luís F., Rodrigues, Adriano, Summavielle, Teresa   +5 more
openaire   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, Volume 2, Issue 1, Page 4-21, March 2026.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source