Metabolites, 2021 The diabetic heart is energetically and metabolically abnormal, with increased fatty acid oxidation and decreased glucose oxidation. One factor contributing to the metabolic dysfunction in diabetes may be abnormal handling of acetyl and acyl groups by ...
Dragana Savic +9 more
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Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis
Journal of Lipid Research, 1997 Acetyl-L-carnitine is known as a reservoir of activated acetyl units and as a modulator of metabolic function. The objective of this study was to quantify the fate of the acetyl moiety of acetyl-L-carnitine in lipogenic pathways.
L Lligona-Trulla +4 more
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Reproductive and Developmental Medicine, 2020 Objective: To investigate the relationship between the concentration of L-carnitine in semen and sperm parameters and investigate the epigenetic profile in sperm cell after L-carnitine usage. Methods: From February 2017 to February 2018, 46 semen samples
Xiao-Hui Jiang +7 more
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Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]
, 2017 Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe +10 more
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Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: a double-blind placebo-controlled study [PDF]
, 2018 Since sperm require high energy levels to perform their specialised function, it is vital that essential nutrients are available for spermatozoa when they develop, capacitate and acquire motility.
Agarwal, A. +8 more
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Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. [PDF]
, 2008 The development of type 2 diabetes is accompanied by decreased immune function and the mechanisms are unclear. We hypothesize that oxidative damage and mitochondrial dysfunction may play an important role in the immune dysfunction in diabetes.
Hao, Jiejie +8 more
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Acetyl-L-carnitine supplementation differently influences nutrient partitioning, serum leptin concentration and skeletal muscle mitochondrial respiration in young and old rats. [PDF]
, 2002 Variations in energy balance, body composition, and nutrient partitioning induced by acetyl-L-carnitine (ALCAR) supplementation were studied in young (2 mo) and old (24 mo) Wistar rats.
Ahrén +42 more
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Protective Effect of Acetyl L-Carnitine on Rat Spermatogenesis Defects Induced by Lead Acetate
مجلة الانبار للعلوم البيطرية, 2023 In this study the influences of the ameliorative effects of Acetyl-L-carnitine, when exposed to lead acetate on functional aspects in spermatogenesis process in the testes of albino male rats, studied, 24 male albino rats weight 178-250 g were ...
Abd UL-Rahman Muhammed Ibrahim +1 more
doaj +1 more source
mBio, 2016 In many eukaryotes, the carnitine shuttle plays a key role in intracellular transport of acyl moieties. Fatty acid-grown Saccharomyces cerevisiae cells employ this shuttle to translocate acetyl units into their mitochondria.
Harmen M. van Rossum +7 more
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Acute effects of acetyl-L-carnitine on sodium cyanide-induced behavioral and biochemical deficits [PDF]
, 1998 In the present study we investigated the effects of acute treatment with acetyl-L-carnitine (50 mg/kg, i.v. 90 min before the sodium cyanide injection) on a sodium cyanide-induced behavioral deficit in the Morris water escape task.
Blokland, Arjan +5 more
core +2 more sources